Traumatic Brain Injury and Age at Onset of Cognitive Impairment in Older Adults

There is a deficiency of knowledge regarding how traumatic brain injury (TBI) is associated with age at onset (AAO) of cognitive impairment in older adults. Participants with a TBI history were identified from the Alzheimer's disease neuroimaging initiative (ADNI 1/GO/2) medical history database. Using an analysis of covariance (ANCOVA) model, the AAO was compared between those with and without TBI, and potential confounding factors were controlled. The AAO was also compared between those with mild TBI (mTBI) and moderate or severe TBI (sTBI). Lastly, the effects of mTBI were analyzed on the AAO of participants with clinical diagnoses of either mild cognitive impairment (MCI) or Alzheimer's disease (AD). The AAO for a TBI group was 68.2 ± 1.1 years [95 % confidence interval (CI) 66.2–70.3, n = 62], which was significantly earlier than the AAO for the non-TBI group of 70.9 ± 0.2 years (95 % CI 70.5–71.4, n = 1197) (p = 0.013). Participants with mTBI history showed an AAO of 68.5 ± 1.1 years (n = 56), which was significantly earlier than the AAO for the non-TBI group (p = 0.032). Participants with both MCI and mTBI showed an AAO of 66.5 ± 1.3 years (95 % CI 63.9–69.1, n = 45), compared to 70.6 ± 0.3 years for the non-TBI MCI group (95 % CI 70.1–71.1, n = 935) (p = 0.016). As a conclusion, a history of TBI may accelerate the AAO of cognitive impairment by two or more years. These results were consistent with reports of TBI as a significant risk factor for cognitive decline in older adults, and TBI is associated with an earlier AAO found in patients with MCI or AD

Age at Injury is Associated with the Long-Term Cognitive Outcome of Traumatic Brain Injuries

Abstract Introduction The association between age at injury (AAI) and long-term cognitive outcome of traumatic brain injuries (TBI) is debatable. Methods Eligible participants with a history of TBI from Alzheimer's Disease Neuroimaging Initiative were divided into a childhood TBI (cTBI) group (the AAI ≤ 21 years old) and an adult TBI (aTBI) group (the AAI > 21 years old). Results The cTBI group has a higher Everyday Cognition total score than the aTBI group. All perceived cognitive functions are worse for the cTBI group than for the aTBI group except memory. By contrast, the cTBI group has higher assessment scores on either the Boston Naming Test or Rey Auditory Verbal Learning Test than the aTBI group. Discussion The AAI is associated with the long-term cognitive outcomes in older adults with a history of TBI

Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants

Introduction Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease. Cerebrospinal fluid (CSF) amyloid β (Aβ) 1-42 is an important Alzheimer's disease biomarker. However, it is inconclusive on how T2DM is related to CSF Aβ1-42. Methods Participants with T2DM were selected from the Alzheimer's Disease Neuroimaging Initiative by searching keywords from the medical history database. A two-way analysis of covariance model was used to analyze how T2DM associates with CSF Aβ1-42 or cerebral cortical Aβ. Results CSF Aβ1-42 was higher in the T2DM group than the nondiabetic group. The inverse relation between CSF Aβ1-42 and cerebral cortical Aβ was independent of T2DM status. Participants with T2DM had a lower cerebral cortical Aβ in anterior cingulate, precuneus, and temporal lobe than controls. Discussion T2DM is positively associated with CSF Aβ1-42 but negatively with cerebral cortical Aβ. The decreased cerebral cortical Aβ associated with T2DM is preferentially located in certain brain regions

Two Photon Decays of ηc\eta_c from Lattice QCD

We present an exploratory lattice study for the two-photon decay of $\eta_c$ using $N_f=2$ twisted mass lattice QCD gauge configurations generated by the European Twisted Mass Collaboration. Two different lattice spacings of $a=0.067$fm and $a=0.085$fm are used in the study, both of which are of physical size of 2$fm$. The decay widths are found to be $1.025(5)$KeV for the coarser lattice and $1.062(5)$KeV for the finer lattice respectively where the errors are purely statistical. A naive extrapolation towards the continuum limit yields $\Gamma\simeq 1.122(14)$KeV which is smaller than the previous quenched result and most of the current experimental results. Possible reasons are discussed.Comment: 13 pages, 7 figures; matches the published versio

Supermassive Black Holes with High Accretion Rates in Active Galactic Nuclei. V. A New Size-Luminosity Scaling Relation for the Broad-Line Region

This paper reports results of the third-year campaign of monitoring super-Eddington accreting massive black holes (SEAMBHs) in active galactic nuclei (AGNs) between 2014-2015. Ten new targets were selected from quasar sample of Sloan Digital Sky Survey (SDSS), which are generally more luminous than the SEAMBH candidates in last two years. H$\beta$ lags ($\tau_{_{\rm H\beta}}$) in five of the 10 quasars have been successfully measured in this monitoring season. We find that the lags are generally shorter, by large factors, than those of objects with same optical luminosity, in light of the well-known $R_{_{\rm H\beta}}-L_{5100}$ relation. The five quasars have dimensionless accretion rates of $\dot{\mathscr{M}}=10-10^3$. Combining measurements of the previous SEAMBHs, we find that the reduction of H$\beta$ lags tightly depends on accretion rates, $\tau_{_{\rm H\beta}}/\tau_{_{R-L}}\propto\dot{\mathscr{M}}^{-0.42}$, where $\tau_{_{R-L}}$ is the H$\beta$ lag from the normal $R_{_{\rm H\beta}}-L_{5100}$ relation. Fitting 63 mapped AGNs, we present a new scaling relation for the broad-line region: $R_{_{\rm H\beta}}=\alpha_1\ell_{44}^{\beta_1}\,\min\left[1,\left(\dot{\mathscr{M}}/\dot{\mathscr{M}}_c\right)^{-\gamma_1}\right]$, where $\ell_{44}=L_{5100}/10^{44}\,\rm erg~s^{-1}$ is 5100 \AA\ continuum luminosity, and coefficients of $\alpha_1=(29.6_{-2.8}^{+2.7})$ lt-d, $\beta_1=0.56_{-0.03}^{+0.03}$, $\gamma_1=0.52_{-0.16}^{+0.33}$ and $\dot{\mathscr{M}}_c=11.19_{-6.22}^{+2.29}$. This relation is applicable to AGNs over a wide range of accretion rates, from $10^{-3}$ to $10^3$. Implications of this new relation are briefly discussed.Comment: 15 pages, 9 figures, 5 table, accepted for publication in The Astrophysical Journa

A Unified Approach to the Classical Statistical Analysis of Small Signals

We give a classical confidence belt construction which unifies the treatment of upper confidence limits for null results and two-sided confidence intervals for non-null results. The unified treatment solves a problem (apparently not previously recognized) that the choice of upper limit or two-sided intervals leads to intervals which are not confidence intervals if the choice is based on the data. We apply the construction to two related problems which have recently been a battle-ground between classical and Bayesian statistics: Poisson processes with background, and Gaussian errors with a bounded physical region. In contrast with the usual classical construction for upper limits, our construction avoids unphysical confidence intervals. In contrast with some popular Bayesian intervals, our intervals eliminate conservatism (frequentist coverage greater than the stated confidence) in the Gaussian case and reduce it to a level dictated by discreteness in the Poisson case. We generalize the method in order to apply it to analysis of experiments searching for neutrino oscillations. We show that this technique both gives correct coverage and is powerful, while other classical techniques that have been used by neutrino oscillation search experiments fail one or both of these criteria.Comment: 40 pages, 15 figures. Changes 15-Dec-99 to agree more closely with published version. A few small changes, plus the two substantive changes we made in proof back in 1998: 1) The definition of "sensitivity" in Sec. V(C). It was inconsistent with our actual definition in Sec. VI. 2) "Note added in proof" at end of the Conclusio

Evidence for e+e−→γχc1,2e^+e^-\to\gamma\chi_{c1, 2} at center-of-mass energies from 4.009 to 4.360 GeV

Using data samples collected at center-of-mass energies of $\sqrt{s}$ = 4.009, 4.230, 4.260, and 4.360 GeV with the BESIII detector operating at the BEPCII collider, we perform a search for the process $e^+e^-\to\gamma\chi_{cJ}$ $(J = 0, 1, 2)$ and find evidence for $e^+e^-\to\gamma\chi_{c1}$ and $e^+e^-\to\gamma\chi_{c2}$ with statistical significances of 3.0$\sigma$ and 3.4$\sigma$, respectively. The Born cross sections $\sigma^{B}(e^+e^-\to\gamma\chi_{cJ})$, as well as their upper limits at the 90% confidence level are determined at each center-of-mass energy.Comment: 8 pages, 7 figures, 3 table

Observation of χc1\chi_{c1} decays into vector meson pairs ϕϕ\phi\phi, ωω\omega\omega, and ωϕ\omega\phi

Decays of $\chi_{c1}$ to vector meson pairs $\phi\phi$, $\omega\omega$ and $\omega\phi$ are observed for the first time using $(106\pm4)\times 10^6$ \psip events accumulated at the BESIII detector at the BEPCII $e^+e^-$ collider. The branching fractions are measured to be $(4.4\pm 0.3\pm 0.5)\times 10^{-4}$, $(6.0\pm 0.3\pm 0.7)\times 10^{-4}$, and $(2.2\pm 0.6\pm 0.2)\times 10^{-5}$, for $\chi_{c1}\to \phi\phi$, $\omega\omega$, and $\omega\phi$, respectively. The observation of $\chi_{c1}$ decays into a pair of vector mesons $\phi\phi$, $\omega\omega$ and $\omega\phi$ indicates that the hadron helicity selection rule is significantly violated in $\chi_{cJ}$ decays. In addition, the measurement of $\chi_{cJ}\to \omega\phi$ gives the rate of doubly OZI-suppressed decay. Branching fractions for $\chi_{c0}$ and $\chi_{c2}$ decays into other vector meson pairs are also measured with improved precision.Comment: 4 pages, 2 figure