The prevalence of hypogonadism in patients with thalassemia major in Iran – a systematic review and meta-analysis study

Background and aims: Hypogonadism is one of the most common endocrine complications in patients with thalassemia major. A simple review of studies show different hypogonadism prevalence and has been reported between 31.3-88% in Iranian patients with thalassemia major. So, this meta-analysis study was conducted to determine the hypogonadism prevalence in Iranian patients with thalassemia major. Methods: This study was conducted based on PRISMA checklist for systematic review and meta-analysis studies. A comprehensive search by two researchers was conducted according to MESH keywords in databases such as Magiran, Iranmedex, SID, Medlib, IranDoc, Scopus, PubMed, Science Direct, Cochrane, Embase, Springer, Online Library Wiley and also search engine Google Scholar. Then, all articles were examined without any time limited until October 2015. Data were analyzed using random effects model and Stata ver. 11.1 software. Results: Sixteen studies involving 2938 patients with average age of 17.34 were identified to analyze in the meta-analysis. Hypogonadism prevalence in patients with thalassemia major in Iran has been estimated 42.3% (CI 95%: 30.7-53.8). Minimum and maximum prevalence in Iran were related to the center (41%) and east (45%), respectively. Hypogonadism prevalence in male and female patients was 49% and 45.2%, respectively. There was no significant relationship between hypogonadism prevalence and year of the study and sample size. Conclusion: The prevalence of hypogonadism in Iranian patients with thalassemia major is high and it is needed to perform a continuous and regular plan and follow up for these patients

Frequency of Kidney Stone Different Compositions in Patients Referred to a Lithotripsy Center in Ilam, West of Iran

Introduction: Ilam is one of the provinces with the highest prevalence of kidney stone. The aim of this study was to calculate the frequency percentage of kidney stones by composition in Ilam.Materials and Methods: This cross-sectional study was conducted on 160 patients referred to the lithotripsy center of Ilam for the treatment of kidney stones from 2014 to 2015 (9 months). A two-part questionnaire including demographic information and stone type was used for collecting data. Finally, the obtained data were analyzed with SPSS version 17.Results: The frequency of kidney stones was 68% in men and 31.8% in women. The prevalence of kidney stones was higher in men than women, but there was no significant relationship between gender and the stone type. The highest prevalence of the stone was in the age group 31-41 years (33.7%) and there was a significant relationship between age and the stone type (P=0.001). The frequency of calcium oxalate (CaOx), mixed, uric acid, and cysteine kidney stones was 61.25%, 36.25%, 1.9%, and 0.6%, respectively. The most prevalent mixed stone was uric acid together with calcium oxalate stones (21.8%) followed by CaOx together with calcium phosphate stones (10.6%).Conclusions: The prevalence of CaOx and uric acid and CaOx stones was high. It is likely the increase in mixed stones in Ilam, especially uric acid and CaOx stones, is due to the nutritional pattern of subjects. More studies are required to determine the relationship between the stone type and diet in this area.Keywords: Kidney stones; Nephrolithiasis; Urolithiasis; Calcium phosphate; Calcium oxalate; Struvite; Uric aci

Prevalence of Vascular Trauma and Related Factors in Iran: A Systematic Review

Background: Managing patients with Vascular Trauma (VT) is essential. This study aimed todetermine the prevalence of VT and its related factors in Iran.Methods: This systematic review was performed by two skilled researchers. To access all thePersian and English articles on VT and its influencing factors (from 2000 to August 2019),in addition to Google Scholar search engine, other international databases, such as PubMed/Medline, Scopus, Embase, Cochrane Library, Science Direct, Web of Science (ISI), anddomestic databases, such as Magiran, IranDoc, National Library of Iran Organization, SID,and Barakatkns were used. Data analysis was conducted by MA (CMA) software.Results: The incidence of lower Lower Vascular Trauma (LVI) trauma was equal to 58.4(95%CI: 41.1-73.8) (I2= 94.67, Q=112.57, P<0.001); the prevalence of upper LVI trauma wasmeasured to be 31.5 (95%CI: 17.7-49.7) (I2=94.48, Q=108.70, P<0.001); the prevalence ofpenetrating trauma was calculated as 61.3 (95% CI: 49.5-71.9); the prevalence of ulnar nerveinjury equaled 9.8 (95%CI: 2.8-28.6); the prevalence of radial nerve trauma was equal to 7.7(95%CI: 1.2-35.4); the prevalence of death cases was reported as 12.3 (95%CI: 5.1-26.9);the prevalence of amputation rate was observed as 8.8 (95%CI: 5.7-13.4); the prevalenceof fasciotomy rate was equal to 22.2 (95%CI: 13.2-34.5); the prevalence of complete arterycutting equaled 55.7 (95% CI: 35.4-74.3),and the prevalence of incomplete artery cutting wasmeasured as 25.5 (95%CI: 12.1-45.9).Conclusion: According to the study results, VT has led to various complications in patients;thus, it is critical to provide the necessary conditions to preserve the patient’s life and preventlife-threatening complications. Such goals could be achieved by preventing this type of traumaand its related complications

Helicobacter pylori infection is associated with anemia in pregnant women- a meta-analysis study

Background and Aim: Recent studies were tested possible role of Helicobacter pylori in iron deficiency anemia in pregnant women but the results of these studies have been different. Therefore, this study aimed to determine the association between H. pylori infection and iron deficiency anemia in pregnant women using meta-analysis. Materials and methods: This study was meta-analysis done based on data bases included: Scopus, PubMed, Science Direct, ProQuest, Cochrane, EMBASE, Web of Science, Springer, Online Library Wiley, Chemical Abstracts, EBSCO as well as the Google Scholar search engine in the period 1990 to 2016 by two independent researchers using standard keyword. Then all articles with inclusion criteria were examined .The data were analyzed by using random effects model Meta-analysis method and with the software Stata Ver.11.1. Results: 7 eligible studies with a sample size of 2115 patients were examined. The relationship between H. pylori and iron deficiency anemia in pregnant women was statistically significant and odds ratio (OR) 1.82 (CI: 95%, 1.43-2.30) was estimated. In 3 study Investigated the relationship of H. pylori associated with hemoglobin and serum ferritin levels found H. Pylori is effective in reducing these two variables and the association was statistically significant (P<0.05). Conclusion: H. pylori plays a role in the etiology of anemia in pregnant women and recommended all anemic pregnant women be checked of H. pylori

Hepatitis B vaccination coverage of physicians and nurses in Iran: A systematic review and meta-analysis study

Background and Aim: Iranian physicians and nurses are not aware of the total extent of&nbsp; HB vaccination, as the most effective way of preventing HBV infection. The current review study aimed at determining the extent of HB vaccination in these two groups. Materials and Methods: The current study was done on the basis of received information from Magiran, Iran medex, IranDoc, SID, Medlib and international databases including Embase, Scopus, Web of Science, Pubmed, Science Direct and also&nbsp; Google Scholar searching motor between . 1993 and 2015, using standard key words. Searching and extraction of data was independently done by two . reviewers. Then, the reviewed articles that had the inclusion criteria were studied. The obtained&nbsp; data was analyzed by means of random effect model and meta-analyses method, using Stata software (Ver:11.1) Results: A total of 4104 subjects were studied in 16 articles. . Hepatitis B vaccination history in physicians and nurses were 88.7% (CI: 95%: 81.4-96) and 93.5% (CI: 95%: 65.3-86.7), respectively. Hepatitis B vaccination coverage of physicians and nurses was estimated to be 73.1 %( CI: 95%: 53.2-92.9) and 76% (CI: 95%: 65.3-86.7), respectively. The relationship between hepatitis B vaccinations coverage with the year of study&nbsp; in physicians&nbsp; was not statistically significant (P=0.146). But, in nurses this relationship was significant (P=0.016). Conclusion: The obtained results show in spite of the fact that &nbsp;approximately two-thirds of physicians&nbsp; and nurses have their complete &nbsp;vaccination plan this fraction is far from an ideal state and it requires to be promoted