Synthesis of ZnO in aqueous media. Influence of several synthesis parameters on particle size and shape

No abstract availabl

Apoyo a la decisión de emplazamientos óptimos de edificios. Localización de un edificio universitario mediante el proceso analítico jerárquico

Uno de los nuevos campos en el que los SIG son necesarios, es la gestión eficaz de los espacios y equipamientos urbanos, tanto desde el punto de vista medioambiental, respetando la idea de desarrollo sostenible; como del mantenimiento de sus infraestructuras, generando soluciones inmediatas a problemas urgentes. En este trabajo se plantea la utilización de una técnica de decisión multicriterio, el Proceso Analítico Jerárquico (AHP), con datos generados por un SIG para determinar sobre la base de diferentes criterios basados en distintos atributos, cual es el emplazamiento más adecuado para construir equipamientos urbanos. Se ha aplicado para determinar el emplazamiento de una biblioteca en el Campus de Montegancedo de la Universidad Politécnica de Madrid, donde se ubica la Facultad de Informática. El AHP, es una herramienta de base matemática que permite estructurar un problema multicriterio en forma visual y construir un modelo jerárquico que representa el problema objeto de estudio. Se pretende concluir que con la aplicación de este tipo de herramientas de decisión se logra una mayor equidad y eficiencia espacial en el resultado final de la decisión sobre el emplazamiento, al mismo tiempo que se minimizan los posibles efectos negativos sobre el medioambiente en una zona de especial protección

Overlapping variants in the blood, tissues and cell lines for patients with intracranial meningiomas are predominant in stem cell-related genes

Objective: Bulk tissue genomic analysis of meningiomas identified common somatic mutations, however, it often excluded blood-related variants. In contrast, genomic characterisation of primary cell lines that can provide critical information regarding growth and proliferation, have been rare. In our work, we identified the variants that are present in the blood, tissues and corresponding cell lines that are likely to be predictive, tumorigenic and progressive. Method: Whole-exome sequencing was used to identify variants and distinguish related pathways that exist in 42 blood, tissues and corresponding cell lines (BTCs) samples for patients with intracranial meningiomas. Conventional sequencing was used for the confirmation of variants. Integrative analysis of the gene expression for the corresponding samples was utilised for further interpretations. Results: In total, 926 BTC variants were detected, implicating 845 genes. A pathway analysis of all BTC genes with damaging variants indicated the 'cell morphogenesis involved in differentiation' stem cell-related pathway to be the most frequently affected pathway. Concordantly, five stem cell-related genes, GPRIN2, ALDH3B2, ASPN, THSD7A and SIGLEC6, showed BTC variants in at least five of the patients. Variants that were heterozygous in the blood and homozygous in the tissues or the corresponding cell lines were rare (average: 1.3 +/- 0.3%), and included variants in the RUNX2 and CCDC114 genes. An analysis comparing the variants detected only in tumours with aggressive features indicated a total of 240 BTC genes, implicating the 'homophilic cell adhesion via plasma membrane adhesion molecules' pathway, and identifying the stem cell-related transcription coactivator NCOA3/AIB1/SRC3 as the most frequent BTC gene. Further analysis of the possible impact of the poly-Q mutation present in the NCOA3 gene indicated associated deregulation of 15 genes, including the up-regulation of the stem cell related SEMA3D gene and the angiogenesis related VEGFA gene. Conclusion: Stem cell-related pathways and genes showed high prevalence in the BTC variants, and novel variants in stem cell-related genes were identified for meningioma. These variants can potentially be used as predictive, tumorigenic and progressive biomarkers for meningioma

Jost-Lehmann-Dyson Representation, Analyticity in Angle Variable and Upper Bounds in Noncommutative Quantum Field Theory

The existence of Jost-Lehmann-Dyson representation analogue has been proved in framework of space-space noncommutative quantum field theory. On the basis of this representation it has been found that some class of elastic amplitudes admits an analytical continuation into complex \cos\vartheta plane and corresponding domain of analyticity is Martin ellipse. This analyticity combined with unitarity leads to Froissart-Martin upper bound on total cross section.Comment: LaTeX, 15 pages, improved version, misprints corrected, the references added, to appear in Theor. Math. Phy

Longitudinal analysis on parasite diversity in honeybee colonies: new taxa, high frequency of mixed infections and seasonal patterns of variation

To evaluate the influence that parasites have on the losses of Apis mellifera it is essential to monitor their presence in the colonies over time. Here we analysed the occurrence of nosematids, trypanosomatids and neogregarines in five homogeneous colonies for up to 21 months until they collapsed. The study, which combined the use of several molecular markers with the application of a massive parallel sequencing technology, provided valuable insights into the epidemiology of these parasites: (I) it enabled the detection of parasite species rarely reported in honeybees (Nosema thomsoni, Crithidia bombi, Crithidia acanthocephali) and the identification of two novel taxa; (II) it revealed the existence of a high rate of co-infections (80% of the samples harboured more than one parasite species); (III) it uncovered an identical pattern of seasonal variation for nosematids and trypanosomatids, that was different from that of neogregarines; (IV) it showed that there were no significant differences in the fraction of positive samples, nor in the levels of species diversity, between interior and exterior bees; and (V) it unveiled that the variation in the number of parasite species was not directly linked with the failure of the colonies

Psychiatric comorbidities in Asperger syndrome are related with polygenic overlap and differ from other Autism subtypes

There is great phenotypic heterogeneity within autism spectrum disorders (ASD), which has led to question their classification into a single diagnostic category. The study of the common genetic variation in ASD has suggested a greater contribution of other psychiatric conditions in Asperger syndrome (AS) than in the rest of the DSM-IV ASD subtypes (Non_AS). Here, using available genetic data from previously performed genome-wide association studies (GWAS), we aimed to study the genetic overlap between five of the most related disorders (schizophrenia (SCZ), major depression disorder (MDD), attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorders (OCD) and anxiety (ANX)), and AS, comparing it with the overlap in Non_AS subtypes. A Spanish cohort of autism trios (N = 371) was exome sequenced as part of the Autism Sequencing Consortium (ASC) and 241 trios were extensively characterized to be diagnosed with AS following DSM-IV and Gillberg's criteria (N = 39) or not (N = 202). Following exome imputation, polygenic risk scores (PRS) were calculated for ASD, SCZ, ADHD, MDD, ANX, and OCD (from available summary data from Psychiatric Genomic Consortium (PGC) repository) in the Spanish trios' cohort. By using polygenic transmission disequilibrium test (pTDT), we reported that risk for SCZ (Pscz = 0.008, corrected-PSCZ = 0.0409), ADHD (PADHD = 0.021, corrected-PADHD = 0.0301), and MDD (PMDD = 0.039, corrected-PMDD = 0.0501) is over-transmitted to children with AS but not to Non_AS. Indeed, agnostic clustering procedure with deviation values from pTDT tests suggested two differentiated clusters of subjects, one of which is significantly enriched in AS (P = 0.025). Subsequent analysis with S-Predixcan, a recently developed software to predict gene expression from genotype data, revealed a clear pattern of correlation between cortical gene expression in ADHD and AS (P < 0.001) and a similar strong correlation pattern between MDD and AS, but also extendable to another non-brain tissue such as lung (P < 0.001). Altogether, these results support the idea of AS being qualitatively distinct from Non_AS autism and consistently evidence the genetic overlap between AS and ADHD, MDD, or SCZ

Evaluaci?n econ?mica de los efectos del cambio clim?tico en la agricultura en la cuenca del r?o Ica, en el peri?do 2017-2030

En la presente investigaci?n hemos establecido los siguientes objetivos: Determinar y evaluar el impacto de los efectos del cambio clim?tico en los resultados econ?micos de los productores agrarios de la cuenca del r?o Ica Determinar el impacto, generado por la variaci?n de la temperatura, en los resultados econ?micos de los productores agrarios de la cuenca del r?o Ica. Determinar el impacto, generado por la variaci?n de la precipitaci?n, en los resultados econ?micos de los productores agrarios de la cuenca del r?o Ic