Real Time Correlators in Hot (2+1)d QCD

We use dimensional reduction techniques to relate real time finite T correlation functions in (2+1) dimensional QCD to bound state parameters in a generalized 't Hooft model with an infinite number of heavy quark and adjoint scalar fields. While static susceptibilities and correlation functions of the DeTar type can be calculated using only the light (static) gluonic modes, the dynamical correlators require the inclusion of the heavy modes. In particular we demonstrate that the leading T perturbative result can be understood in terms of the bound states of the 2d model and that consistency requires bound state trajectories composed of both quarks and adjoint scalars. We also propose a non-perturbative expression for the dynamical DeTar correlators at small spatial momenta.Comment: 21 pages, Latex, uses axodra

Composite fermion wave functions as conformal field theory correlators

It is known that a subset of fractional quantum Hall wave functions has been expressed as conformal field theory (CFT) correlators, notably the Laughlin wave function at filling factor $\nu=1/m$ ($m$ odd) and its quasiholes, and the Pfaffian wave function at $\nu=1/2$ and its quasiholes. We develop a general scheme for constructing composite-fermion (CF) wave functions from conformal field theory. Quasiparticles at $\nu=1/m$ are created by inserting anyonic vertex operators, $P_{\frac{1}{m}}(z)$, that replace a subset of the electron operators in the correlator. The one-quasiparticle wave function is identical to the corresponding CF wave function, and the two-quasiparticle wave function has correct fractional charge and statistics and is numerically almost identical to the corresponding CF wave function. We further show how to exactly represent the CF wavefunctions in the Jain series $\nu = s/(2sp+1)$ as the CFT correlators of a new type of fermionic vertex operators, $V_{p,n}(z)$, constructed from $n$ free compactified bosons; these operators provide the CFT representation of composite fermions carrying $2p$ flux quanta in the $n^{\rm th}$ CF Landau level. We also construct the corresponding quasiparticle- and quasihole operators and argue that they have the expected fractional charge and statistics. For filling fractions 2/5 and 3/7 we show that the chiral CFTs that describe the bulk wave functions are identical to those given by Wen's general classification of quantum Hall states in terms of $K$-matrices and $l$- and $t$-vectors, and we propose that to be generally true. Our results suggest a general procedure for constructing quasiparticle wave functions for other fractional Hall states, as well as for constructing ground states at filling fractions not contained in the principal Jain series.Comment: 26 pages, 3 figure

Two-vibron bound states in alpha-helix proteins : the interplay between the intramolecular anharmonicity and the strong vibron-phonon coupling

The influence of the intramolecular anharmonicity and the strong vibron-phonon coupling on the two-vibron dynamics in an $\alpha$-helix protein is studied within a modified Davydov model. The intramolecular anharmonicity of each amide-I vibration is considered and the vibron dynamics is described according to the small polaron approach. A unitary transformation is performed to remove the intramolecular anharmonicity and a modified Lang-Firsov transformation is applied to renormalize the vibron-phonon interaction. Then, a mean field procedure is realized to obtain the dressed anharmonic vibron Hamiltonian. It is shown that the anharmonicity modifies the vibron-phonon interaction which results in an enhancement of the dressing effect. In addition, both the anharmonicity and the dressing favor the occurrence of two different bound states which the properties strongly depend on the interplay between the anharmonicity and the dressing. Such a dependence was summarized in a phase diagram which characterizes the number and the nature of the bound states as a function of the relevant parameters of the problem. For a significant anharmonicity, the low frequency bound states describe two vibrons trapped onto the same amide-I vibration whereas the high frequency bound states refer to the trapping of the two vibrons onto nearest neighbor amide-I vibrations.Comment: may 2003 submitted to Phys. Rev.

Quantum interference structures in trapped ion dynamics beyond the Lamb-Dicke and rotating wave approximations

We apply wave packet methods to study an ion-trap system in the strong excitation regime imposing neither the rotating wave nor the Lamb-Dicke approximations. By this approach we show the existence of states with restricted phase space evolution, as a genuine consequence of quantum interference between wave packet fractions. A particular instance of such a state oscillates between maximal entanglement and pure disentanglement between the constitute subsystems. The characteristic crossover time is very rapid making them suitable for state preparations of EPR or Schrodinger cat states. Over longer time periods the dynamics of these states exhibits collapse-revival patterns with well resolved fractional revivals in autocorrelation, inversion and entanglement.Comment: 11 pages, 5 figures. Replaced with revised version. Phys. Rev. A 77, 053808 (2008

AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma

Cutaneous malignant melanoma (CMM) is the deadliest form of skin cancer and clinically challenging due to its propensity to develop therapy resistance. Reactive oxygen species (ROS) can induce DNA damage and play a significant role in CMM. MTH1 protein protects from ROS damage and is often overexpressed in different cancer types including CMM. Herein, we report that MTH1 inhibitor TH1579 induced ROS levels, increased DNA damage responses, caused mitotic arrest and suppressed CMM proliferation leading to cell death both in vitro and in an in vivo xenograft CMM zebrafish disease model. TH1579 was more potent in abrogating cell proliferation and inducing cell death in a heterogeneous co-culture setting when compared with CMM standard treatments, vemurafenib or trametinib, showing its broad anticancer activity. Silencing MTH1 alone exhibited similar cytotoxic effects with concomitant induction of mitotic arrest and ROS induction culminating in cell death in most CMM cell lines tested, further emphasizing the importance of MTH1 in CMM cells. Furthermore, overexpression of receptor tyrosine kinase AXL, previously demonstrated to contribute to BRAF inhibitor resistance, sensitized BRAF mutant and BRAF/NRAS wildtype CMM cells to TH1579. AXL overexpression culminated in increased ROS levels in CMM cells. Moreover, silencing of a protein that has shown opposing effects on cell proliferation, CAV-1, decreased sensitivity to TH1579 in a BRAF inhibitor resistant cell line. AXL-MTH1 and CAV-1-MTH1 mRNA expressions were correlated as seen in CMM clinical samples. Finally, TH1579 in combination with BRAF inhibitor exhibited a more potent cell killing effect in BRAF mutant cells both in vitro and in vivo. In summary, we show that TH1579-mediated efficacy is independent of BRAF/NRAS mutational status but dependent on the expression of AXL and CAV-1

Skyrmion ↔\leftrightarrow pseudoSkyrmion Transition in Bilayer Quantum Hall States at ν=1\nu =1

Bilayer quantum Hall states at $\nu =1$ have been demonstrated to possess a distinguished state with interlayer phase coherence. The state has both excitations of Skyrmion with spin and pseudoSkyrmion with pseudospin. We show that Skyrmion $\leftrightarrow$ pseudoSkyrmion transition arises in the state by changing imbalance between electron densities in both layers; PseudoSkyrmion is realized at balance point, while Skyrmion is realized at large imbalance. The transition can be seen by observing the dependence of activation energies on magnetic field parallel to the layers.Comment: 12 pages, no figure

P171Elevated free fetal haemoglobin threatens vasculoprotection in the fetal circulation of preeclamptic pregnancy

Placental up-regulation of free fetal haemoglobin (fHbF) occurs in preeclamptic (PE) pregnancy. Heme oxygenase-1 (HO-1) is an important vasculoprotective enzyme in the catabolism of the associated heme porphyrin structure. We have previously shown that fHbF negatively influences the vasculoprotective capacity of the fetal circulation. Here we study fHbF levels in the fetal cord blood of pregnancies complicated by PE; a pathology associated with dysregulated fetoplacental vascular tone. We have previously shown that fHbF binds nitric oxide (NO) to elicit elevated vascular resistance in the fetoplacental circulation, using ex vivo human dual placental perfusion and in vitro placental endothelial cell shear stress studies. Furthermore, fHbF causes morphological changes to the fetoplacental endothelium. Here we hypothesise that elevated levels of fHbF in fetal plasma associated with placental pathology contribute to fetoplacental hypertension. Purpose: To evaluate and derive a robust cord blood collection and processing protocol for the accurate measurement of fetal plasma fHbF levels in normal and PE pregnancies. Methods: Fetal venous cord blood was collected by syringe and needle, or Vacutainer method into either EDTA or citrate tubes, within 10 minutes of partum. Plasma recovery occurred immediately, or after 30 minutes, prior to centrifugation at 2000g x 10 min at room temperature. Following evaluation to reduce mechanical haemolysis, newly collected normal & PE plasma (n=13 & 6, respectively) was subjected to ELISAs for HbF and HO-1. Results: Venipuncture collection of cord venous blood taken from the cord-placenta insertion point by Vacutainer system with a 21G needle, into citrate collection tubes with immediate centrifugation prevented mechanical haemolysis. There was no difference in plasma HO-1 between groups (medians = 5.9 & 5.3 ng/mL; normal & PE, respectively; Mann-Whitney). Whilst there was no difference in fHbF between groups (Mann-Whitney), variability was high in the PE group and there were some very high values for fHbF compared to the normal range, whilst fHbF values in the control group were within a tighter lower range (medians & ranges = 45.9 & 0-206 and 118.8 & 29-640 μg/mL). Conclusion: Fetal plasma HO-1 levels appear stable in preeclamptic fetal plasma, permitting fHbF to remain unchecked in some cases. High pathophysiological levels of fHbF in some cases of PE pregnancies are capable of evoking elevated vascular resistance within the fetoplacental circulation, caused by nitric oxide sequestration and disruption to the endothelium. Further evaluation is require

Matrix Model Description of Laughlin Hall States

We analyze Susskind's proposal of applying the non-commutative Chern-Simons theory to the quantum Hall effect. We study the corresponding regularized matrix Chern-Simons theory introduced by Polychronakos. We use holomorphic quantization and perform a change of matrix variables that solves the Gauss law constraint. The remaining physical degrees of freedom are the complex eigenvalues that can be interpreted as the coordinates of electrons in the lowest Landau level with Laughlin's wave function. At the same time, a statistical interaction is generated among the electrons that is necessary to stabilize the ground state. The stability conditions can be expressed as the highest-weight conditions for the representations of the W-infinity algebra in the matrix theory. This symmetry provides a coordinate-independent characterization of the incompressible quantum Hall states.Comment: 31 pages, large additions on the path integral and overlaps, and on the W-infinity symmetr

An analysis of photoemission and inverse photoemission spectra of Si(111) and sulphur-passivated InP(001) surfaces

Photoemission (PES) and inverse-photoemission spectra (IPES) for the sulphur-passivated InP(001) surface are compared with theoretical predictions based on density-functional calculations. As a test case for our methods, we also present a corresponding study of the better known Si(111) surface. The reported spectra for InP(001)-S agree well with the calculated ones if the surface is assumed to consist of a mixture of two phases, namely, the fully S-covered $(2\times2)$-reconstructed structure, which contains four S atoms in the surface unit-cell, and a $(2\times2)$ structure containing two S and two P atoms per unit cell. The latter has recently been identified in total-energy calculations as well as in core-level spectra of S-passivated Si(111)-$(2\times1)$ is in excellent agreement with the calculations. The comparison of the experimental-PES with our calculations provides additional considerations regarding the nature of the sample surface. It is also found that the commonly-used density-of-states approximation to the photo- and inverse- photoemission spectra is not valid for these systems.Comment: Submitted to Phys. Rev. B; 6 postscript formatted pages; 7 figures in gif format; postscript figures available upon reques

Effective action for the order parameter of the deconfinement transition of Yang-Mills theories

The effective action for the Polyakov loop serving as an order parameter for deconfinement is obtained in one-loop approximation to second order in a derivative expansion. The calculation is performed in $d\geq 4$ dimensions, mostly referring to the gauge group SU(2). The resulting effective action is only capable of describing a deconfinement phase transition for $d>d_{\text{cr}}\simeq 7.42$. Since, particularly in $d=4$, the system is strongly governed by infrared effects, it is demonstrated that an additional infrared scale such as an effective gluon mass can change the physical properties of the system drastically, leading to a model with a deconfinement phase transition.Comment: 23 pages, 4 figures, minor improvements, version to appear in PR