Mechanisms Generating Line Trajectories

In this work the problem of designing mechanisms to guide a line along a ruled surface is considered. This is motivated by the idea of illustrating, by means of a physical model, the set of lines in a general linear line complex. Cylindrical symmetry implies that the problem reduces of designing a mechanism to move a line along the regulus of a rectangular hyperbolic paraboloid. This leads to the study of several simple ruled surfaces and congruences of lines. In particular the paper studies the regulus of the elliptical hyperboloid, the cylindroid and linear line congruences. In each case relatively simple mechanisms are designed to constrain a line in the mechanism to a given space of lines

Functional implications of minor mandibular asymmetry: clinical and digital research on a sample of healthy patients

OBJECTIVE.The aim of the study is to evaluate the influence that the mandibular asymmetry could have towards the other components of the Stomathognatic system and to further related structures from a functional point of view. MATERIALS and METHODS. A sample of 18 young asymmetric patients, in healthy status, was investigated with clinical evaluation and questionnaires and digital devices such as Electromiography, Stabilometry, T-scan and Formetric. Descriptive and quantitative statistical analysis were performed. RESULTS. ASIM electromyography index was significant only in a short percentage of the sample. Hypertonia of temporalis muscle in the same side of mandibular deviation and the cross-activation of the contralateral masseter were present. The data of the stabilometric platform showed that only 33% of patients had a load discrepancy between right and left side. All patients presented similar and limited postural anomalies during the Formetric examination. No significant results emerged from statistics . CONCLUSIONS. From the emerging data, mandibular asymmetry does not seem to be considered a potential risk factor for the development of functional anomalies both in the stomatognatic system and in the postural one. The only issue that should be considered is the condylar retrusion of the mandibular shortest side that is a possible destabilizing factor of the TMJ condyle-disc coordination

Functional implications of minor mandibular asymmetry: clinical and digital research on a sample of healthy patients

OBJECTIVE.The aim of the study is to evaluate the influence that the mandibular asymmetry could have towards the other components of the Stomathognatic system and to further related structures from a functional point of view. MATERIALS and METHODS. A sample of 18 young asymmetric patients, in healthy status, was investigated with clinical evaluation and questionnaires and digital devices such as Electromiography, Stabilometry, T-scan and Formetric. Descriptive and quantitative statistical analysis were performed. RESULTS. ASIM electromyography index was significant only in a short percentage of the sample. Hypertonia of temporalis muscle in the same side of mandibular deviation and the cross-activation of the contralateral masseter were present. The data of the stabilometric platform showed that only 33% of patients had a load discrepancy between right and left side. All patients presented similar and limited postural anomalies during the Formetric examination. No significant results emerged from statistics . CONCLUSIONS. From the emerging data, mandibular asymmetry does not seem to be considered a potential risk factor for the development of functional anomalies both in the stomatognatic system and in the postural one. The only issue that should be considered is the condylar retrusion of the mandibular shortest side that is a possible destabilizing factor of the TMJ condyle-disc coordination

Astrocomp: a web service for the use of high performance computers in Astrophysics

Astrocomp is a joint project, developed by the INAF-Astrophysical Observatory of Catania, University of Roma La Sapienza and Enea. The project has the goal of providing the scientific community of a web-based user-friendly interface which allows running parallel codes on a set of high-performance computing (HPC) resources, without any need for specific knowledge about parallel programming and Operating Systems commands. Astrocomp provides, also, computing time on a set of parallel computing systems, available to the authorized user. At present, the portal makes a few codes available, among which: FLY, a cosmological code for studying three-dimensional collisionless self-gravitating systems with periodic boundary conditions; ATD, a parallel tree-code for the simulation of the dynamics of boundary-free collisional and collisionless self-gravitating systems and MARA, a code for stellar light curves analysis. Other codes are going to be added to the portal.Comment: LaTeX with elsart.cls and harvard.sty (included). 7 pages. To be submitted to a specific journa

GALNT2 as a novel modulator of adipogenesis and adipocyte insulin signaling

Background/objectives: A better understanding of adipose tissue biology is crucial to tackle insulin resistance and eventually coronary heart disease and diabetes, leading causes of morbidity and mortality worldwide. GALNT2, a GalNAc-transferase, positively modulates insulin signaling in human liver cells by down-regulating ENPP1, an insulin signaling inhibitor. GALNT2 expression is increased in adipose tissue of obese as compared to that of non-obese individuals. Whether this association is secondary to a GALNT2-insulin sensitizing effect exerted also in adipocytes is unknown. We then investigated in mouse 3T3-L1 adipocytes the GALNT2 effect on adipogenesis, insulin signaling and expression levels of both Enpp1 and 72 adipogenesis-related genes. Methods: Stable over-expressing GALNT2 and GFP preadipocytes (T 0 ) were generated. Adipogenesis was induced with (R+) or without (R−) rosiglitazone and investigated after 15 days (T 15 ). Lipid accumulation (by Oil Red-O staining) and intracellular triglycerides (by fluorimetric assay) were measured. Lipid droplets (LD) measures were analyzed at confocal microscope. Gene expression was assessed by RT-PCR and insulin-induced insulin receptor (IR), IRS1, JNK and AKT phosphorylation by Western blot. Results: Lipid accumulation, triglycerides and LD measures progressively increased from T 0 to T 15 R- and furthermore to T 15 R+. Such increases were significantly higher in GALNT2 than in GFP cells so that, as compared to T 15 R+GFP, T 15 R- GALNT2 cells showed similar (intracellular lipid and triglycerides accumulation) or even higher (LD measures, p < 0.01) values. In GALNT2 preadipocytes, insulin-induced IR, IRS1 and AKT activation was higher than that in GFP cells. GALNT2 effect was totally abolished during adipocyte maturation and completely reversed at late stage maturation. Such GALNT2 effect trajectory was paralleled by coordinated changes in the expression of Enpp1 and adipocyte-maturation key genes. Conclusions: GALNT2 is a novel modulator of adipogenesis and related cellular phenotypes, thus becoming a potential target for tackling the obesity epidemics and its devastating sequelae

Association of a homozygous GCK missense mutation with mild diabetes

Background: Homozygous inactivating GCK mutations have been repeatedly reported to cause severe hyperglycemia, presenting as permanent neonatal diabetes mellitus (PNDM). Conversely, only two cases of GCK homozygous mutations causing mild hyperglycemia have been so far described. We here report a novel GCK mutation (c.1116G>C, p.E372D), in a family with one homozygous member showing mild hyperglycemia. Methods: GCK mutational screening was carried out by Sanger sequencing. Computational analyses to investigate pathogenicity and molecular dynamics (MD) were performed for GCK-E372D and for previously described homozygous mutations associated with mild (n = 2) or severe (n = 1) hyperglycemia, used as references. Results: Of four mildly hyperglycemic family-members, three were heterozygous and one, diagnosed in the adulthood, was homozygous for GCK-E372D. Two nondiabetic family members carried no mutations. Fasting glucose (p = 0.016) and HbA1c (p = 0.035) correlated with the number of mutated alleles (0–2). In-silico predicted pathogenicity was not correlated with the four mutations’ severity. At MD, GCK-E372D conferred protein structure flexibility intermediate between mild and severe GCK mutations. Conclusions: We present the third case of homozygous GCK mutations associated with mild hyperglycemia, rather than PNDM. Our in-silico analyses support previous evidences suggesting that protein stability plays a role in determining clinical severity of GCK mutations

On the 2015 outburst of the EXor variable star V1118 Ori

After a long-lasting period of quiescence of about a decade, the source V1118 Ori, one of the most representative members of the EXor variables, is now outbursting. Since the initial increase of the near-infrared flux of about 1 mag (JHK bands) registered on 2015 September 22, the source brightness has remained fairly stable. We estimate DeltaV about 3 mag with respect to the quiescence phase. An optical/near-IR low-resolution spectrum has been obtained with the Large Binocular Telescope instruments MODS and LUCI2, and compared with a spectrum of similar spectral resolution and sensitivity level taken during quiescence. Together with the enhancement of the continuum, the outburst spectrum presents a definitely higher number of emission lines, in particular HI recombination lines of the Balmer, Paschen, and Brackett series, along with bright permitted lines of several species, forbidden atomic lines, and CO ro-vibrational lines. Both mass accretion and mass loss rates have significantly increased (by to about an order of magnitude, mass accretion rate = 1.2-4.8 10^-8 M_sun/yr, mass loss rate = 0.8-2 10^-9 M_sun/yr) with respect to the quiescence phase. If compared with previous outbursts, the present one appears less energetic. Alternatively, it could already be in the fading phase (with the maximum brightness level reached when the source was not visible), or, viceversa, still in the rising phase.Comment: Accepted ApJ Letter

Effective conductivity of inertial flows through porous media

We study two-dimensional incompressible inertial flows through porous media. At core (small) scale, we prove that the constitutive, nonlinear model can be rewritten into a linear one by means of a new parameter K* which encompasses all the inertial effects. In natural (large-scale) formations, K* is erratically changing, and we analytically compute its counterpart, which is coined generalized effective conductivity, by the self-consistent approach (SCA). In spite of its approximate nature, the SCA leads to simple results that are in good agreement with Monte Carlo simulations