170 research outputs found

    Система высшего образования Тайваня глазами иностранных студентов на современном этапе

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    Объект:система высшего образования Тайваня.Предмет:отношение иностранных студентов к высшему образованию Тайваня. В процессе исследования проводились сбор теоретической информации о системе Высшего образования Тайваня,интервью и опрос среди студентов,обучавшихся на Тайване,анализ полученных данных. Область применения:положения и выводы,содержащиеся в работе,могут быть использованы для дальнейшей разработки вопроса глобализации образования,при создании моделей образовательной интеграции,при проведении исследований,касающихся образования Тайваня,при ведении статистистической сводкиObject:system of higher education in Taiwan.Subject:attitude of foreign students towards the higher education in Taiwan. In the course of this research paper was gathered theoretical information about the higher education system in Taiwan,were conducted polls and interviews among the students who were studying in Taiwan,the obtained data was analyzed. The basic thesis and conclusions of this paper can be applied in further research of the problem of globalization in education, in development of models of educational integration,in research concerning the educational system of Taiwan,in data collation,results of this research can be used in designing educational programs for foreign students

    Перевод паровой котельной на водогрейный режим г. Кедровый Томской области

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    Выпускная квалификационная работа 172 страницы, 17 табл., 8 рисунков, 21 источник литературы, 8 листов графического материала. КОТЕЛЬНАЯ ПРОИЗВОДСТВЕННО - ОТОПИТЕЛЬНАЯ, КОТЕЛ ПАРОВОЙ, ВОДОГРЕЙНЫЙ РЕЖИМ, ТЕПЛОВОЙ, ГИДРАВЛИЧЕСКИЙ, АЭРОДИНАМИЧЕСКИЙ РАСЧЕТ, ЭКОНОМИЧЕСКИЙ ЭФФЕКТ. Целью работы является перевод котла ДКВр-10-13 с парового режима работы в водогрейный.Final qualifying work of 172 pages, 17 tab., 8 figures, 21 source of literature, 8 sheets of graphic material. INDUSTRIAL BOILER - Heating, steam boiler, hot-water boilers, thermal, hydraulic, aerodynamic calculations, the economic effect. The aim is to transfer the boiler DKVr-10-13 with steam mode to hot water

    South African Menopause Society revised consensus position statement on menopausal hormone therapy

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    The South African Menopause Society (SAMS) consensus position statement on menopausal hormone therapy (HT) 2014 is a revision of the SAMS Council consensus statement on menopausal HT published in the SAMJ in May 2007. Information presented in the previous statement has been re-evaluated and new evidence has been incorporated. While the recommendations pertaining to HT remain similar to those in the previous statement, the 2014 revision includes a wider range of clinical benefits for HT, the inclusion of non-hormonal alternatives such as selective serotonin reuptake inhibitors and serotonin noradrenaline reuptake inhibitors for the management of vasomotor symptoms, and an appraisal of bioidentical hormones and complementary medicines used for treatment of menopausal symptoms. New preparations that are likely to be more commonly used in the future are also mentioned. The revised statement emphasises that commencing HT during the 'therapeutic window of opportunity' maximises the benefit-to-risk profile of therapy in symptomatic menopausal women

    Separating Lentiviral Vector Injection and Induction of Gene Expression in Time, Does Not Prevent an Immune Response to rtTA in Rats

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    BACKGROUND: Lentiviral gene transfer can provide long-term expression of therapeutic genes such as erythropoietin. Because overexpression of erythropoietin can be toxic, regulated expression is needed. Doxycycline inducible vectors can regulate expression of therapeutic transgenes efficiently. However, because they express an immunogenic transactivator (rtTA), their utility for gene therapy is limited. In addition to immunogenic proteins that are expressed from inducible vectors, injection of the vector itself is likely to elicit an immune response because viral capsid proteins will induce "danger signals" that trigger an innate response and recruit inflammatory cells. METHODOLOGY AND PRINCIPAL FINDINGS: We have developed an autoregulatory lentiviral vector in which basal expression of rtTA is very low. This enabled us to temporally separate the injection of virus and the expression of the therapeutic gene and rtTA. Wistar rats were injected with an autoregulatory rat erythropoietin expression vector. Two or six weeks after injection, erythropoietin expression was induced by doxycycline. This resulted in an increase of the hematocrit, irrespective of the timing of the induction. However, most rats only responded once to doxycycline administration. Antibodies against rtTA were detected in the early and late induction groups. CONCLUSIONS: Our results suggest that, even when viral vector capsid proteins have disappeared, expression of foreign proteins in muscle will lead to an immune respons
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