ISM composition through X-ray spectroscopy of LMXBs

The diffuse interstellar medium (ISM) is an integral part of the evolution of the entire Galaxy. Metals are produced by stars and their abundances are the direct testimony of the history of stellar evolution. However, the interstellar dust composition is not well known and the total abundances are yet to be accurately determined. We probe ISM dust composition, total abundances, and abundance gradients through the study of interstellar absorption features in the high-resolution X-ray spectra of Galactic low-mass X-ray binaries (LMXBs). We use high-quality grating spectra of nine LMXBs taken with XMM-Newton. We measure the column densities of O, Ne, Mg, and Fe with an empirical model and estimate the Galactic abundance gradients. The column densities of the neutral gas species are in agreement with those found in the literature. Solids are a significant reservoir of metals like oxygen and iron. Respectively, 15-25 % and 65-90 % of the total amount of O I and Fe I is found in dust. The dust amount and mixture seem to be consistent along all the lines-of-sight (LOS). Our estimates of abundance gradients and predictions of local interstellar abundances are in agreement with those measured at longer wavelengths. Our work shows that X-ray spectroscopy is a very powerful method to probe the ISM. For instance, on a large scale the ISM appears to be chemically homogeneous showing similar gas ionization ratios and dust mixtures. The agreement between the abundances of the ISM and the stellar objects suggests that the local Galaxy is also chemically homogeneous.Comment: 13 pages, 10 figures, 5 tables, accepted to A&

Image Ellipticity from Atmospheric Aberrations

We investigate the ellipticity of the point-spread function (PSF) produced by imaging an unresolved source with a telescope, subject to the effects of atmospheric turbulence. It is important to quantify these effects in order to understand the errors in shape measurements of astronomical objects, such as those used to study weak gravitational lensing of field galaxies. The PSF modeling involves either a Fourier transform of the phase information in the pupil plane or a ray-tracing approach, which has the advantage of requiring fewer computations than the Fourier transform. Using a standard method, involving the Gaussian weighted second moments of intensity, we then calculate the ellipticity of the PSF patterns. We find significant ellipticity for the instantaneous patterns (up to more than 10%). Longer exposures, which we approximate by combining multiple (N) images from uncorrelated atmospheric realizations, yield progressively lower ellipticity (as 1 / sqrt(N)). We also verify that the measured ellipticity does not depend on the sampling interval in the pupil plane using the Fourier method. However, we find that the results using the ray-tracing technique do depend on the pupil sampling interval, representing a gradual breakdown of the geometric approximation at high spatial frequencies. Therefore, ray tracing is generally not an accurate method of modeling PSF ellipticity induced by atmospheric turbulence unless some additional procedure is implemented to correctly account for the effects of high spatial frequency aberrations. The Fourier method, however, can be used directly to accurately model PSF ellipticity, which can give insights into errors in the statistics of field galaxy shapes used in studies of weak gravitational lensing.Comment: 9 pages, 5 color figures (some reduced in size). Accepted for publication in the Astrophysical Journa

Right-handed charged currents in the era of the Large Hadron Collider

We discuss the phenomenology of right-handed charged currents in the framework of the Standard Model Effective Field Theory, in which they arise due to a single gauge-invariant dimension-six operator. We study the manifestations of the nine complex couplings of the $W$ to right-handed quarks in collider physics, flavor physics, and low-energy precision measurements. We first obtain constraints on the couplings under the assumption that the right-handed operator is the dominant correction to the Standard Model at observable energies. We subsequently study the impact of degeneracies with other Beyond-the-Standard-Model effective interactions and identify observables, both at colliders and low-energy experiments, that would uniquely point to right-handed charged currents.Comment: 50 pages plus appendices and reference

Investigation to determine the effects of long-term bed rest on G-tolerance and on psychomotor performance Final report

Prolonged bed rest effects on gravity tolerance and psychomotor performance of human

Sustainability of small reservoirs and large scale water availability under current conditions and climate change

Semi-arid river basins often rely on reservoirs for water supply. Small reservoirs may impact on large-scale water availability both by enhancing availability in a distributed sense and by subtracting water for large downstream user communities, e.g. served by large reservoirs. Both of these impacts of small reservoirs are subject to climate change. Using a case-study on North-East Brazil, this paper shows that climate change impacts on water availability may be severe, and impacts on distributed water availability from small reservoirs may exceed impacts on centralised water availability from large reservoirs. Next, the paper shows that the effect of small reservoirs on water availability from large reservoirs may be significant, and increase both in relative and absolute sense under unfavourable climate change

Combining economic and social goals in the design of production systems by using ergonomics standards

In designing of production systems, economic and social goals can be combined, if ergonomics is integrated into the design process. More than 50 years of ergonomics research and practice have resulted in a large number of ergonomics standards for designing physical and organizational work environments. This paper gives an overview of the 174 international ISO and European CEN standards in this field, and discusses their applicability in design processes. The available standards include general recommendations for integrating ergonomics into the design process, as well as specific requirements for manual handling, mental load, task design, human-computer-interaction, noise, heat, body measurements, and other topics. The standards can be used in different phases of the design process: allocation of system functions between humans and machines, design of the work organization, work tasks and jobs, design of work environment, design of work equipment, hardware and software, and design of workspace and workstation. The paper is meant to inform engineers and managers involved in the design of production systems about the existence of a large number of ISO and CEN standards on ergonomics, which can be used to optimize human well-being and overall system performance.review;standard;standardization;ergonomics;CEN;ISO;human factors;production engineering;production planning

Ethical considerations in genomic research in South Africa

The conduct of genomic research in South Africa (SA) raises a number of ethical challenges that need to be addressed in its design and execution. These include, for example, considerations of consent, community engagement, stigmatisation, feedback of findings and ensuring that genomic research is of benefit to patients and researchers in SA. We provide an overview of the current debates on some of these issues and pointers for further reading

Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network

Ubiquitination relies on a subtle balance between selectivity and promiscuity achieved through specific interactions between ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s). Here, we report how a single aspartic to glutamic acid substitution acts as a dynamic switch to tip the selectivity balance of human E2s for interaction toward E3 RING-finger domains. By combining molecular dynamic simulations, experimental yeast-two-hybrid screen of E2-E3 (RING) interactions and mutagenesis, we reveal how the dynamics of an internal salt-bridge network at the rim of the E2-E3 interaction surface controls the balance between an “open”, binding competent, and a “closed”, binding incompetent state. The molecular dynamic simulations shed light on the fine mechanism of this molecular switch and allowed us to identify its components, namely an aspartate/glutamate pair, a lysine acting as the central switch and a remote aspartate. Perturbations of single residues in this network, both inside and outside the interaction surface, are sufficient to switch the global E2 interaction selectivity as demonstrated experimentally. Taken together, our results indicate a new mechanism to control E2-E3 interaction selectivity at an atomic level, highlighting how minimal changes in amino acid side-chain affecting the dynamics of intramolecular salt-bridges can be crucial for protein-protein interactions. These findings indicate that the widely accepted sequence-structure-function paradigm should be extended to sequence-structure-dynamics-function relationship and open new possibilities for control and fine-tuning of protein interaction selectivity