Indirect Signs of the Peccei-Quinn Mechanism

In the Standard Model, the renormalization of the QCD vacuum angle $\theta$ is extremely tiny, and small $\theta$ is technically natural. In the general Standard Model effective field theory (SMEFT), however, $\Delta\theta$ is quadratically divergent, reflecting the fact that new sources of hadronic CP-violation typically produce $\mathcal O(1)$ threshold corrections to $\theta$. The observation of such CP-violating interactions would therefore be in tension with solutions to the strong CP problem in which $\theta=0$ is an ultraviolet boundary condition, pointing to the Peccei-Quinn mechanism as the explanation for why $\theta$ is small in the infrared. We study the quadratic divergences in $\theta$ arising from dimension-6 SMEFT operators and discuss the discovery prospects for these operators at electric dipole moment experiments, the LHC, and future proton-proton colliders.Comment: 27 pages, 3 figures. Comments welcome

Trajectories in life satisfaction before and during COVID-19 with respect to perceived valence and self-efficacy

Actions taken by governments to counteract the spread of the COVID-19 pandemic led to profound restrictions in daily lives, especially for adolescents and young adults, with closed schools and universities, travel restrictions, and reduction in social contacts. The purpose of the current study is to investigate the development of life satisfaction with assessments before and during the pandemic, including separate measurement occasions during a strict lockdown and when the implemented restrictions were relaxed again. Data are based on the German Personality Panel (GePP) with 1,920 young adults, assessed on four measurement occasions over a period of three years. Using latent change score modeling, we investigate the outbreak of the COVID-19 pandemic with respect to its perception as a critical life event over time. Further, we examine the influence of self-efficacy on change in life-satisfaction, as the belief in one’s innate abilities has been shown to promote health related behavior and buffers against effects of negatively perceived critical life events. While average life satisfaction remained stable across time, we found a main effect of perceived positive valence and self-efficacy on latent change in life satisfaction at the within person level. Expressions of self-efficacy did not moderate the influence of the perception of the pandemic on self-reported life satisfaction. This study provides an important contribution to the recent COVID-19 literature as well as to the debate on stability and change of self-reported life satisfaction

The association between muscle strength and activity limitations in patients with the hypermobility type of Ehlers–Danlos syndrome : the impact of proprioception

Purpose: The patients diagnosed with Ehlers-Danlos Syndrome Hypermobility Type (EDS-HT) are characterized by pain, proprioceptive inacuity, muscle weakness, potentially leading to activity limitations. In EDS-HT, a direct relationship between muscle strength, proprioception and activity limitations has never been studied. The objective of the study was to establish the association between muscle strength and activity limitations and the impact of proprioception on this association in EDS-HT patients. Methods: Twenty-four EDS-HT patients were compared with 24 controls. Activity limitations were quantified by Health Assessment Questionnaire (HAQ), Six-Minute Walk test (6MWT) and 30-s chair-rise test (30CRT). Muscle strength was quantified by handheld dynamometry. Proprioception was quantified by movement detection paradigm. In analyses, the association between muscle strength and activity limitations was controlled for proprioception and confounders. Results: Muscle strength was associated with 30CRT (r = 0.67, p = <0.001), 6MWT (r = 0.58, p = <0.001) and HAQ (r = 0.63, p = <0.001). Proprioception was associated with 30CRT (r = 0.55, p <0.001), 6MWT (r = 0.40, p = <0.05) and HAQ (r = 0.46, p < 0.05). Muscle strength was found to be associated with activity limitations, however, proprioceptive inacuity confounded this association. Conclusions: Muscle strength is associated with activity limitations in EDS-HT patients. Joint proprioception is of influence on this association and should be considered in the development of new treatment strategies for patients with EDS-HT. Implications for rehabilitation : Reducing activity limitations by enhancing muscle strength is frequently applied in the treatment of EDS-HT patients. Although evidence regarding treatment efficacy is scarce, the current paper confirms the rationality that muscle strength is an important factor in the occurrence of activity limitations in EDS-HT patients. Although muscle strength is the most dominant factor that is associated with activity limitations, this association is confounded by proprioception. In contrast to common belief proprioception was not directly associated with activity limitations but confounded this association. Controlling muscle strength on the bases of proprioceptive input may be more important for reducing activity limitations than just enhancing sheer muscle strength

Synthesis of Solution-Phase Phosphoramidite and Phosphite Ligand Libraries and Their In Situ Screening in the Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids

Herein, we report the automated parallel synthesis of solution-phase libraries of phosphoramidite ligands for the development of enantioselective catalysts. The ligand libraries are screened in situ in the asymmetric rhodium-catalyzed addition of arylboronic acids to aldehydes and imines. It is shown that the described methodology results in the straightforward discovery of leads for highly efficient enantioselective catalysts.

A note on the relationship between GARCH and symmetric stable processes

This note provides some explanations and extensions for the interesting results in Ghose and Kroner (1995). Specifically, we address the following points: (1) It is shown that the stable distribution and the stationary ARCH distributions are partially nested with respect to their tail shapes; (2) A novel interpretation of the McCulloch estimator is developed from the vantage point of extreme value theory; (3) This interpretation not only explains the apparent bias in some of the reported estimates, but it also helps in remedying the problem. Taken together, all three points reinforce the main conclusion of Ghose and Kroner

Personality Development in Emerging Adulthood—How the Perception of Life Events and Mindset Affect Personality Trait Change

Personality changes throughout the life course and change is often caused by environmental influences, such as critical life events. In the present study, we investigate personality trait development in emerging adulthood as a result of experiencing two major life events: graduating from school and moving away from home. Thereby, we examined the occurrence of the two life events per se and the subjective perception of the critical life event in terms of valence. In addition, we postulate a moderation effect of the construct of mindset, which emphasizes that beliefs over the malleability of global attributes can be seen as predictors of resilience to challenges. This suggests that mindset acts as a buffer for these two distinct events. In a large longitudinal sample of 1,243 people entering adulthood, we applied latent structural equation modeling to assess mean-level changes in the Big Five, the influence of life events per se, the subjective perception of life events, and a moderating role of mindset. In line with maturity processes, results showed significant mean-level changes in all Big Five traits. While no changes in the Big Five dimensions were noted when the mere occurrence of an event is assessed, results indicated a greater increase in extraversion and diminished increase in emotional stability when we accounted for the individual's (positive/negative) perception of the critical life event. In case of extraversion, this also holds true for the moderator mindset. Our findings contribute valuable insights into the relevance of subjective appraisals to life events and the importance of underlying processes to these events

The development of trait greed during young adulthood: A simultaneous investigation of environmental effects and negative core beliefs

This publication is with permission of the rights owner (Sage) freely accessible.Recent models of personality development have emphasized the role of the environment in terms of selection and socialization effects and their interaction. Our study provides partial evidence for these models and, crucially, extends these models by adding a person variable: Core beliefs, which are defined as mental representations of experiences that individuals have while pursuing need-fulfilling goals. Specifically, we report results from a longitudinal investigation of the development of trait greed across time. Based on data from the German Personality Panel, we analyzed data on 1,965 young adults on up to 4 occasions, spanning a period of more than 3 years. According to our results, negative core beliefs that have so far been proposed only in the clinical literature (e.g., being unloved or being insecure) contributed to the development of trait greed, indicating that striving for material goals might be a substitute for unmet needs in the past. Additionally, greedy individuals more often self-selected themselves into business-related environments, which presumably allow them to fulfill their greed-related need to earn a lot of money. Our results expose important mechanisms for trait greed development. Regarding personality development in general, core beliefs were identified as an important variable for future theory building.Deutsche Forschungsgemeinschafthttps://doi.org/10.13039/501100001659Peer Reviewe

Equal but different! Improving care for older LGBT+ adults

International human rights movements have improved the visibility and equality of lesbian, gay, bisexual and transgender+ (LGBT+) communities and their members. Health outcomes for LGBT+ people remain, however, worse than for their non-LGBT+ peers. Older LGBT+ people have experienced fewer positive changes, in part due to their lived experience of discrimination and their ongoing, unintentional invisibility in medical and social care. This article highlights the impacts of societal structure, health and social care on the lives of older LGBT+ people including physical and mental health, End of Life, Dementia, Housing and Care Settings, and a focus on the experiences of trans-people. We look at the existing improvements developed by LGBT+ communities (and their allies) and propose refreshing Person-Centred Care to improve inclusivity. Finally, we provide a framework for looking at the areas in which service challenges arise and suggest ways to address these to make health and social care services more ready to meet the needs of older LGBT+ people

Abnormal vaginal bleeding in women of reproductive age: a descriptive study of initial management in general practice

<p>Abstract</p> <p>Background</p> <p>Abnormal vaginal bleeding (AVB) in women of reproductive age is a common reason for consulting a general practitioner. Nevertheless, how general practitioners (GPs) choose to initially manage AVB is largely unknown, as is the prevalence of underlying pathology of AVB in primary care.</p> <p>Methods</p> <p>To investigate the initial diagnostic procedures and treatment for AVB used in general practice, we performed a descriptive study based on computerised medical records. New consultations for AVB in 2000 and 2001 were selected. Patient characteristics, diagnostic procedures and treatment were analysed.</p> <p>Results</p> <p>In total, 270 new consultations were included. The majority of patients (75%) consulted the GP for AVB only once. GPs performed diagnostic procedures in 54% of all consultations. Overall, additional diagnostic procedures revealed abnormalities in 11% of women. However, the diagnostic procedures implemented by the GPs varied widely per bleeding type and contraceptive use. Anaemia was found in 36% of 45 women tested. Uterine fibroids were found in 41% of 27 women examined by ultrasound. Medication was prescribed in 34% of all consultations. A gynaecological referral was registered in 4% of all contacts.</p> <p>Conclusion</p> <p>Initially, GPs tend to follow a policy of expectant management in women of reproductive age with AVB. However, when additional diagnostic procedures were performed, anaemia and uterine fibroids were found in a considerable number of women.</p