String propagation in four-dimensional dyonic black hole background

We study string propagation in an exact, four-dimensional dyonic black hole background. The general solutions describing string configurations are obtained by solving the string equations of motion and constraints. By using the covariant formalism, we also investigate the propagation of physical perturbations along the string in the given curved background.Comment: 19 pages, Tex (macro phyzzx is needed

Strings Near a Rindler Or Black Hole Horizon

Orbifold techniques are used to study bosonic, type II and heterotic strings in Rindler space at integer multiples N of the Rindler temperature, and near a black hole horizon at integer multiples of the Hawking temperature, extending earlier results of Dabholkar. It is argued that a Hagedorn transition occurs nears the horizon for all N>1.Comment: 13 pages, harvmac, (references added

Plane waves with weak singularities

We study a class of time dependent solutions of the vacuum Einstein equations which are plane waves with weak null singularities. This singularity is weak in the sense that though the tidal forces diverge at the singularity, the rate of divergence is such that the distortion suffered by a freely falling observer remains finite. Among such weak singular plane waves there is a sub-class which do not exhibit large back reaction in the presence of test scalar probes. String propagation in these backgrounds is smooth and there is a natural way to continue the metric beyond the singularity. This continued metric admits string propagation without the string becoming infinitely excited. We construct a one parameter family of smooth metrics which are at a finite distance in the space of metrics from the extended metric and a well defined operator in the string sigma model which resolves the singularity.Comment: 22 pages, Added references and clarifying comment

CMB quadrupole suppression: II. The early fast roll stage

Within the effective field theory of inflation, an initialization of the classical dynamics of the inflaton with approximate equipartition between the kinetic and potential energy of the inflaton leads to a brief fast roll stage that precedes the slow roll regime. The fast roll stage leads to an attractive potential in the wave equations for the mode functions of curvature and tensor perturbations. The evolution of the inflationary perturbations is equivalent to the scattering by this potential and a useful dictionary between the scattering data and observables is established.Implementing methods from scattering theory we prove that this attractive potential leads to a suppression of the quadrupole moment for CMB and B-mode angular power spectra. The scale of the potential is determined by the Hubble parameter during slow roll. Within the effective field theory of inflation at the grand unification (GUT) energy scale we find that if inflation lasts a total number of efolds N_{tot} ~ 59, there is a 10-20% suppression of the CMB quadrupole and about 2-4% suppression of the tensor quadrupole. The suppression of higher multipoles is smaller, falling off as 1/l^2. The suppression is much smaller for N_{tot} > 59, therefore if the observable suppression originates in the fast roll stage, there is the upper bound N_{tot} ~ 59.Comment: Some comments and references adde

Phenotypic, transcriptomic, and genomic features of clonal plasma cells in light-chain amyloidosis

Immunoglobulin light-chain amyloidosis (AL) and multiple myeloma (MM) are 2 distinct monoclonal gammopathies that involve the same cellular compartment: clonal plasma cells (PCs). Despite the fact that knowledge about MM PC biology has significantly increased in the last decade, the same does not apply for AL. Here, we used an integrative phenotypic, molecular, and genomic approach to study clonal PCs from 24 newly diagnosed patients with AL. Through principal-component-analysis, we demonstrated highly overlapping phenotypic profiles between AL and both monoclonal gammopathy of undetermined significance and MM PCs. However, in contrast to MM, highly purified fluorescence-activated cell-sorted clonal PCs from AL (n = 9) showed almost normal transcriptome, with only 38 deregulated genes vs normal PCs; these included a few tumor-suppressor (CDH1, RCAN) and proapoptotic (GLIPR1, FAS) genes. Notwithstanding, clonal PCs in AL (n=11) were genomically unstable, with a median of 9 copy number alterations (CNAs) per case, many of such CNAs being similar to those found in MM. Whole-exome sequencing (WES) performed in 5 AL patients revealed a median of 15 nonrecurrent mutations per case. Altogether, our results show that in the absence of a unifying mutation by WES, clonal PCs in AL display phenotypic and CNA profiles similar to MM, but their transcriptome is remarkably similar to that of normal PCs

Mechanical behavior of asphalt mixtures containing silica gels as warm additives

This paper presents the results of a study of some compounds capable of absorbing water into their structure (silica gel), as potential foaming binders. Asphalt mixtures were manufactured at different manufacturing and compaction temperatures, using four different silica gels. Static and dynamic tests were carried out to determine their behavior in asphalt mixtures. The results were compared with those obtained using hot-mix asphalt and warm-mix asphalt manufactured with zeolite. The lab results showed a similar behavior of asphalt mixtures containing either silica gel or zeolite.The research presented herein was sponsored by the Research Office of Universidad de La Frontera (DIUFRO) under the project number DI15-0089

Sinks in the Landscape, Boltzmann Brains, and the Cosmological Constant Problem

This paper extends the recent investigation of the string theory landscape in hep-th/0605266, where it was found that the decay rate of dS vacua to a collapsing space with a negative vacuum energy can be quite large. The parts of space that experience a decay to a collapsing space, or to a Minkowski vacuum, never return back to dS space. The channels of irreversible vacuum decay serve as sinks for the probability flow. The existence of such sinks is a distinguishing feature of the string theory landscape. We describe relations between several different probability measures for eternal inflation taking into account the existence of the sinks. The local (comoving) description of the inflationary multiverse suffers from the so-called Boltzmann brain (BB) problem unless the probability of the decay to the sinks is sufficiently large. We show that some versions of the global (volume-weighted) description do not have this problem even if one ignores the existence of the sinks. We argue that if the number of different vacua in the landscape is large enough, the anthropic solution of the cosmological constant problem in the string landscape scenario should be valid for a broad class of the probability measures which solve the BB problem. If this is correct, the solution of the cosmological constant problem may be essentially measure-independent. Finally, we describe a simplified approach to the calculations of anthropic probabilities in the landscape, which is less ambitious but also less ambiguous than other methods.Comment: 42 pages, 5 figures, the paper is substantially extended, a section on the cosmological constant is addeed; the version published in JCA

Hemispherical power asymmetry: parameter estimation from CMB WMAP5 data

We reexamine the evidence of the hemispherical power asymmetry, detected in the CMB WMAP data using a new method. At first, we analyze the hemispherical variance ratios and compare these with simulated distributions. Secondly, working within a previously-proposed CMB bipolar modulation model, we constrain model parameters: the amplitude and the orientation of the modulation field as a function of various multipole bins. Finally, we select three ranges of multipoles leading to the most anomalous signals, and we process corresponding 100 Gaussian, random field (GRF) simulations, treated as observational data, to further test the statistical significance and robustness of the hemispherical power asymmetry. For our analysis we use the Internally-Linearly-Coadded (ILC) full sky map, and KQ75 cut-sky V channel, foregrounds reduced map of the WMAP five year data (V5). We constrain the modulation parameters using a generic maximum a posteriori method. In particular, we find differences in hemispherical power distribution, which when described in terms of a model with bipolar modulation field, exclude the field amplitude value of the isotropic model A=0 at confidence level of ~99.5% (~99.4%) in the multipole range l=[7,19] (l=[7,79]) in the V5 data, and at the confidence level ~99.9% in the multipole range l=[7,39] in the ILC5 data, with the best fit (modal PDF) values in these particular multipole ranges of A=0.21 (A=0.21) and A=0.15 respectively. However, we also point out that similar or larger significances (in terms of rejecting the isotropic model), and large best-fit modulation amplitudes are obtained in GRF simulations as well, which reduces the overall significance of the CMB power asymmetry down to only about 94% (95%) in the V5 data, in the range l=[7,19] (l=[7,79]).Comment: 24 pages, 10 figures; few typos corrected; published in JCA

Testing String Theory with CMB

Future detection/non-detection of tensor modes from inflation in CMB observations presents a unique way to test certain features of string theory. Current limit on the ratio of tensor to scalar perturbations, r=T/S, is r < 0.3, future detection may take place for r > 10^{-2}-10^{-3}. At present all known string theory inflation models predict tensor modes well below the level of detection. Therefore a possible experimental discovery of tensor modes may present a challenge to string cosmology. The strongest bound on r in string inflation follows from the observation that in most of the models based on the KKLT construction, the value of the Hubble constant H during inflation must be smaller than the gravitino mass. For the gravitino mass in the usual range, m_{3/2} < O(1) TeV, this leads to an extremely strong bound r < 10^{-24}. A discovery of tensor perturbations with r > 10^{-3} would imply that the gravitinos in this class of models are superheavy, m_{3/2} > 10^{13} GeV. This would have important implications for particle phenomenology based on string theory.Comment: 13 pages, 2 figure