Resonant Metalenses for Breaking the Diffraction Barrier

We introduce the resonant metalens, a cluster of coupled subwavelength resonators. Dispersion allows the conversion of subwavelength wavefields into temporal signatures while the Purcell effect permits an efficient radiation of this information in the far-field. The study of an array of resonant wires using microwaves provides a physical understanding of the underlying mechanism. We experimentally demonstrate imaging and focusing from the far-field with resolutions far below the diffraction limit. This concept is realizable at any frequency where subwavelength resonators can be designed.Comment: 4 pages, 3 figure

Lipopeptides as dimerization inhibitors of HIV-1 protease

In AIDS therapy, attempts have been made to inhibit the virus-encoded enzymes, e.g, HIV-1 protease, using active site-directed inhibitors. This approach is questionable, however, due to virus mutations and the high toxicity of the drugs, An alternative method to inhibit the dimeric HIV protease is the targeting of the interface region of the protease subunits in order to prevent subunit dimerization and enzyme activity, This approach should be less prone to inactivation by mutation, A list of improved 'dimerization inhibitors' of HIV-1 protease is presented. The main structural features are a short `interface' peptide segment, including non-natural amino acids, and an aliphatic N-terminal blocking group. The high inhibitory power of some of the lipopeptides {[}e.g, palmitoyl-Tyr-Glu-Leu-OH, palmitoyl-Tyr-Glu-(L-thyronine)-OH, palmitoyl-Tyr-Glu-(L-biphenyl-alanine)-OH] with low nanomolar K-i values in the enzyme test suggests that mimetics with good bio-availability can be derived for AIDS therapy

Diffuse field cross-correlations: Scattering theory and electromagnetic experiments

The passive estimation of impulse responses from ambient noise correlations arouses increasing interest in seismology, acoustics, optics and electromagnetism. Assuming the equipartition of the noise field, the cross-correlation function measured with non-invasive receiving probes converges towards the difference of the causal and anti-causal Green’s functions. Here, we consider the case when the receiving field probes are antennas which are well coupled to a complex medium – a scenario of practical relevance in electromagnetism. We propose a general approach based on the scattering matrix formalism to explore the convergence of the cross-correlation function. The analytically derived theoretical results for chaotic systems are confirmed in microwave measurements within a mode-stirred reverberation chamber. This study provides new fundamental insights into the Green’s function retrieval technique and paves the way for a new technique to characterize electromagnetic antennas.French Agence Nationale de la Recherche (reference ANR-17- ASTR-0017); European Union (European Regional Development Fund (ERDF)), French region of Brittany and Rennes Métropole (CPER Project SOPHIE/STIC & Ondes); Institut Universitaire de France (IUF)

Time-resolved dynamics of electron wave packets in chaotic and regular quantum billiards with leads

We perform numerical studies of the wave packet propagation through open quantum billiards whose classical counterparts exhibit regular and chaotic dynamics. We show that for t less or similar to tau (tau being the Heisenberg time), the features in the transmitted and reflected currents are directly related to specific classical trajectories connecting the billiard leads. In contrast, the long-time asymptotics of the wave packet dynamics is qualitatively different for classical and quantum billiards. In particularly, the decay of the quantum system obeys a power law that depends on the number of decay channels, and is not sensitive to the nature of classical dynamics (chaotic or regular).Comment: 5 pages, 4 figure

Anti-HIV-1 activity of cellulose acetate phthalate: Synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles

BACKGROUND: Cellulose acetate phthalate (CAP), a promising candidate microbicide for prevention of sexual transmission of the human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted disease (STD) pathogens, was shown to inactivate HIV-1 and to block the coreceptor binding site on the virus envelope glycoprotein gp120. It did not interfere with virus binding to CD4. Since CD4 is the primary cellular receptor for HIV-1, it was of interest to study CAP binding to HIV-1 complexes with soluble CD4 (sCD4) and its consequences, including changes in the conformation of the envelope glycoprotein gp41 within virus particles. METHODS: Enzyme-linked immunosorbent assays (ELISA) were used to study CAP binding to HIV-1-sCD4 complexes and to detect gp41 six-helix bundles accessible on virus particles using antibodies specific for the α-helical core domain of gp41. RESULTS: 1) Pretreatment of HIV-1 with sCD4 augments subsequent binding of CAP; 2) there is synergism between CAP and sCD4 for inhibition of HIV-1 infection; 3) treatment of HIV-1 with CAP induced the formation of gp41 six-helix bundles. CONCLUSIONS: CAP and sCD4 bind to distinct sites on HIV-1 IIIB and BaL virions and their simultaneous binding has profound effects on virus structure and infectivity. The formation of gp41 six-helical bundles, induced by CAP, is known to render the virus incompetent for fusion with target cells thus preventing infection

Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41

The human monoclonal antibody (mAb) HK20 neutralizes a broad spectrum of primary HIV-1 isolates by targeting the highly conserved heptad repeat 1 (HR1) of gp41, which is transiently exposed during HIV-1 entry. Here we present the crystal structure of the HK20 Fab in complex with a gp41 mimetic 5-Helix at 2.3 Å resolution. HK20 employs its heavy chain CDR H2 and H3 loops to bind into a conserved hydrophobic HR1 pocket that is occupied by HR2 residues in the gp41 post fusion conformation. Compared to the previously described HR1-specific mAb D5, HK20 approaches its epitope with a different angle which might favor epitope access and thus contribute to its higher neutralization breadth and potency. Comparison of the neutralization activities of HK20 IgG, Fab and scFv employing both single cycle and multiple cycle neutralization assays revealed much higher potencies for the smaller Fab and scFv over IgG, implying that the target site is difficult to access for complete antibodies. Nevertheless, two thirds of sera from HIV-1 infected individuals contain significant titers of HK20-inhibiting antibodies. The breadth of neutralization of primary isolates across all clades, the higher potencies for C-clade viruses and the targeting of a distinct site as compared to the fusion inhibitor T-20 demonstrate the potential of HK20 scFv as a therapeutic tool

Monitoraggio dell'attività acustica per la valutazione della stabilità di cavità sotterranee

Lo studio dei meccanismi di degrado delle volte di cavità sotterranee, che possono condurre allo sprofondamento di porzioni di terreno in superficie, ha portato all'installazione di una strumentazione sperimentale per il monitoraggio acustico, all'interno di una miniera abbandonata in Lorena (Francia). Le prime analisi, condotte sui dati registrati durante una campagna di prove in sito, hanno contribuito alla validazione del metodo mostrando che il monitoraggio acustico è in grado di individuare e captare gli eventuali distacchi di blocchi. La ricerca, in corso di svolgimento, prevede l'approfondimento delle tecniche di analisi dei dati, attraverso l'applicazione ad altri siti strumentati, con l'obiettivo finale di localizzare le aree più attive ed i periodi di crisi, che possono precedere lo sprofondamento superficial

Experimental Study of Passive Defect Detection and Localization in Thin Plates from Noise Correlation

AbstractThis paper reports experimental results on a passive imaging technique for structural health monitoring to detect the occurrence of defects in plate-like structures. This technique is based on the fact that the active transient response between two sensors can be passively retrieved by cross-correlating the ambient noise-field recorded on these two sensors. A correlation matrix is estimated from friction noise recorded on a transducer array. It is observed that the accuracy of the estimated transient responses strongly depends on the spatial distribution of noise sources. The best convergence is obtained when the noise is uniformly distributed over the whole plate area. Defects are localized by applying a dispersive beamforming algorithm to the difference between the correlation matrices obtained with and without (w/o) defect. It is shown that the quality of the active transient response reconstruction is not a strong requirement for the defect localization. Indeed, the defect is successfully localized even if the noise source distribution is not uniform, provided that it remains spatially stationary between the states w/o defect. A simple theoretical framework is proposed to interpret these results