29 research outputs found

    Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease

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    Behcet's disease is a genetically complex disease of unknown etiology characterized by recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed a genome-wide association study with 311,459 SNPs in 1,215 individuals with Behcet's disease (cases) and 1,278 healthy controls from Turkey. We confirmed the known association of Behcet's disease with HLA-B*51 and identified a second, independent association within the MHC Class I region. We also identified an association at IL10 (rs1518111, P = 1.88 x 10(-8)). Using a meta-analysis with an additional five cohorts from Turkey, the Middle East, Europe and Asia, comprising a total of 2,430 cases and 2,660 controls, we identified associations at IL10 (rs1518111, P = 3.54 x 10(-18), odds ratio = 1.45, 95% CI 1.34-1.58) and the IL23R-IL12RB2 locus (rs924080, P = 6.69 x 10(-9), OR = 1.28, 95% CI 1.18-1.39). The disease-associated IL10 variant (the rs1518111 A allele) was associated with diminished mRNA expression and low protein production

    Behçet Uveitis in the American Midwest

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    Purpose: Behçet disease is most common in Asia, the Middle East and North Africa (Silk Road). We compare clinical presentation and course of Behçet uveitis in patients of Silk Road and non‐Silk Road descent. Methods: Retrospective review of patients evaluated at the University of Illinois January 1983 ‐ Ju ly 2010. Results: Of 6134 new uveitis patients, 36 with available medical records met diagnostic criteria for Behçet disease. 10 (28%) were of Silk Road origin. Retinal vasculitis was the most common ocular manifestation, followed by panuveitis and retinitis. Ocular and systemic manifestations were similar between groups. 78% were treated with s ystemic immunosuppression, which reduced inflammatory attack rate. Conclusions: Behçet disease is uncommon in the Midwest United States. Three quarters of patients in this series were not of Silk Road descent. Physicians should consider the diagnosis of Behçet disease in any patient with retinal vasculitis or uveitis regardless of ethnicity
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