Hereditary gingival fibromatosis: clinical and ultrastructural features of a new family

Objective: This article describes the diagnosis, clinical and microscopic (histopathology and ultrastructural) features and treatment of a new family with hereditary gingival fibromatosis (HGF) and highlights the importance of this genetic condition. Study Design: To characterize the pattern of inheritance and the clinical features, members of a new family with HGF were examined. The pedigree was reliably constructed including the four latest generations of family. Hematoxylin and eosin staining and ultrastructural analysis were performed with the gingival tissue. Results: Examination of the family pedigree revealed that the patient III-2 represent the index patient of this family (initial patient with a mutation), which was transmitted to her daughter through an autosomal dominant mode of inheritance. The affected patients showed a generalized gingival overgrowth. The patient was treated with surgical procedures of gingivectomy and gingivoplasty. The diagnosis was confirmed by histopathology examination that showed a well-structured epithelium with elongated and thin papillae inserted in fibrous connective tissue with increased amount of collagen. The ultrastructural aspects of the tissue show collagen fibrils exhibiting their typically repeating banding pattern with some fibrils displaying loops at their end. Moreover, it was possible to seen in some regions fibrillar component presenting tortuous aspects and loss of the alignment among them. Conclusions: This HGF frequently resulted in both esthetic and functional problems. The genetic pattern of this Brazilian family suggested a new mutation, which was later transmitted by an autosomal dominant trait

Two rare cases of oral metastasis arising from lung adenocarcinoma and esophageal carcinoma

Metastasis to the oral cavity are rare, representing only 1% of all oral malignancies, and originate from various sites such as the breast, prostate, lung and kidney. Clinically, they can simulate reactive and inflammatory lesions common in the oral cavity, and the clinical and microscopic diagnosis of these metastasis is a challenge. In this article, we report two new cases of esophageal and lung metastasis to oral tissues, highlighting their clinical characteristics and the process of diagnostic elucidation. We emphasize the importance for clinicians to consider the possibility of metastatic lesions in the oral cavity in patients previously diagnosed with malignant lesions in distant tissues and organs

GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location

Gastric cancer (GC) is the second most common cause of cancer-related deaths in the world. This study aims to investigate the differential tissue expression of ppGalNAc-T15 and to evaluate its possible association with clinical-pathological parameters and outcome of gastric adenocarcinoma patients. For these 70 patients were evaluated the expression by immunohistochemistry to ppGalNAc-T15. Our results showed that 33 (47.1%) patients were ppGalNAC-T15+ positive and 37 (52.9%) negative. Positive staining for ppGalNAc-T15 was significantly present in patients older than 60 years (P=0.0306) and submitted to total gastrectomy (P=0.0087). Also, some results remained at the limit of significance as surgical standing (P=0.0562) and histological grade (P=0.0549). Therefore, the ppGalNAc-T15 immunoreactivity can be useful to understand the prognosis of patients with gastric cancer

ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ

Intraoral stents in preventing adverse radiotherapeutic effects in lip cancer patients

AimTo fabricate and evaluate the efficacy of individualized intraoral stents to minimize the potential side effects of radiation on oral tissues in patients with early stages of lip cancer.BackgroundLower lip cancer is a common tumor found almost exclusively in middle-aged and elderly males. Surgery is the most common treatment of choice, although for less extensive lesions, exclusive radiotherapy may be preferred. Some studies have found that the use of intraoral stents in patients with intraoral cancer (e.g., of the tongue or floor of the mouth) obtained favorable results in preventing unnecessary radiation doses to adjacent normal tissue and reducing oral complications. However, studies investigating the efficacy of individualized intraoral stents in patients with lip cancer have not been reported in the literature.Materials and methodsSix patients with early stage lip cancer were eligible for curative radiotherapy and personalized intraoral stents. The stents were fabricated and all participants were evaluated for the occurrence of oral complications.ResultsThe regions of the oral mucosa protected from radiation by intraoral stents showed no mucositis. One patient complained of mild oral dryness but without interference in habits. At follow-up, none of the patients had late xerostomia or signs of dental caries by radiation.ConclusionsThe use of individualized intraoral stents was shown to be promising in reducing the adverse effects of radiation therapy in lip cancer patients. These findings highlight the importance of a multidisciplinary team during oncological therapy

Avaliação agroindustrial e parâmetros genético de progênies de cana-de-açúcar em fase inicial na zona canavieira do Litoral Norte de Pernambuco Agroindustrial evaluation and genetic parameters of sugarcane progenies at the initial phase in a sugarcane plantation zone of north coast of Pernambuco

Neste trabalho, objetivou-se avaliar o desempenho agronômico, industrial e a magnitude dos parâmetros genético de progênies de cana-de-açúcar na zona canavieira do Litoral Norte de Pernambuco. Os experimentos foram desenvolvidos durante o ano agrícola 2006/2007 no Litoral Norte de Pernambuco, no município de Igarassu, dentro de área da Usina São José. O delineamento experimental foi de blocos casualizados, com cinco repetições, utilizando-se como tratamentos 24 genótipos (20 provenientes dos cruzamentos e quatro variedades padrões). A parcela constou de três sulcos de 6 m, espaçados de 1,30 m, com 10 plântulas por sulco, (espaçados de 0,6 m dentro do sulco, totalizando 30 plântulas por parcela), perfazendo uma área total de 23,4 m². O corte foi realizado no décimo mês após o transplantio, onde foram avaliadas as seguintes variáveis: tonelada de cana por hectare (TCH), tonelada de pol por hectare (TPH), Fibra (FB), pol % corrigida (PCC), pureza (PZA), Brix (BX) e açúcar total recuperável (ATR). As progênies dos cruzamentos: RB855035 X RB 72454; RB 865230 X RB855035; Tuc71-7 X RB72454 e RB72454 X Tuc71-7, destacaram-se para as variáveis TPH, FB, PZA e BX. Há variabilidade genética entre as progênies dos cruzamentos para todas as variáveis avaliadas. As estimativas de h²m foram expressivas para as variáveis TPH, TCH, PCC, FB, BX e ATR, indicando a possibilidade de êxito na seleção dessas variáveis dentro da região canavieira do Litoral Norte de Pernambuco.<br>The objective of our research was to evaluate the agronomical, industrial performance and the magnitude of the genetic parameters of initial phase sugarcane progenies in the north coast of Pernambuco. Experimental works were developed during the agricultural year of 2006/2007 in the sugarcane plantation zone in the north coast of Pernambuco, in the district of Igarassu, in the area of the São José industrial plant. The experimental delineation was randomized blocks with five repetitions, using 24 genotypes as treatment (20 from the crossings and 4 standard varieties). The parcel was planted in three furrows of 6 m, spaced by 1.30 m with 10 seedlings per furrow (spaced by 0.6 m within the furrow), totalizing a total area of 23.4 m². Harvest was done in the 10th month after the transplantation, where were evaluated the following variables: pol tons per hectare (PTH), sugarcane tons per hectare (STH), fiber (FB), corrected pol % (CPP), purity (PTY), brix (BX) and total retrievable sugar (TRS). The progenies of the crossings: RB855035 X RB72454; RB865230 X RB855035; Tuc71-7 X RB 72454 and RB 72454X Tuc71-7, overtopped for most of the studied variables. There is genetical variability among the progenies of the crossings for all the evaluated variables. The h²m estimations were expressive for the variables STH, PTH, CPP, FB, BX and TRS, indicating the possibility of success in the selection of these variables within the sugarcane plantation region of North Coast of Pernambuco