SUMOylation and calcium signalling: potential roles in the brain and beyond

Small ubiquitin-like modi er (SUMO) conjugation (or SUMOylation) is a post-translational protein modi cation implicated in alterations to protein expression, localization and func- tion. Despite a number of nuclear roles for SUMO being well characterized, this process has only started to be explored in relation to membrane proteins, such as ion channels. Cal- cium ion (Ca2+) signalling is crucial for the normal functioning of cells and is also involved in the pathophysiological mechanisms underlying relevant neurological and cardiovascu- lar diseases. Intracellular Ca2+ levels are tightly regulated; at rest, most Ca2+ is retained in organelles, such as the sarcoplasmic reticulum, or in the extracellular space, whereas depolarization triggers a series of events leading to Ca2+ entry, followed by extrusion and reuptake. The mechanisms that maintain Ca2+ homoeostasis are candidates for modulation at the post-translational level. Here, we review the effects of protein SUMOylation, including Ca2+ channels, their proteome and other proteins associated with Ca2+ signalling, on vital cellular functions, such as neurotransmission within the central nervous system (CNS) and in additional systems, most prominently here, in the cardiac system

Notes sur quelques esp\ue8ces d\u27Echinides fossiles de Syrie

Volume: 17Start Page: 219End Page: 24

Description des Echinodermes tertiaires du Portugal

P. de Loriol ; tableau stratigraphique par J.C. Berkeley Cotte

Notes on some Species of Fossil Echinoids of Syria, with Notes by R. Fourtau: A Translation of \u3cem\u3eNotes sur Quelques Espèces d\u27Echinides Fossiles de Syrie, Avec des Notes de R. Fourtau\u3c/em\u3e

https://digitalcommons.usf.edu/bin_books/1048/thumbnail.jp

Description of the Tertiary Echinoderms of Portugal: A Translation of \u3cem\u3eDescription des échinodermes tertiaries du Portugal\u3c/em\u3e

https://digitalcommons.usf.edu/bin_books/1051/thumbnail.jp

Notes on some Species of Fossil Echinoids of Syria, with Notes by R. Fourtau: A Translation of \u3cem\u3eNotes sur Quelques Espèces d\u27Echinides Fossiles de Syrie, Avec des Notes de R. Fourtau\u3c/em\u3e

https://digitalcommons.usf.edu/bin_books/1048/thumbnail.jp