ASSOCIAÇÃO ENTRE HORMÔNIO ANTI-MÜLLERIANO E POPULAÇÃO FOLICULAR OVARIANA: UMA REVISÃO SISTEMÁTICA

Anti-Müllerian hormone (AMH) has gained increasing interest as a biomarker of ovarian follicular reserve. Therefore, the present study aims to present a systematic review of recent findings related to AMH, with emphasis on its role as a biomarker of ovarian follicular reserve in different domestic species. For that, searches were carried out in databases of scientific electronic libraries, in search of articles that addressed the present theme. The studies found were analyzed and submitted to inclusion and exclusion criteria that allowed the selection of those that met the objectives of the present study. In total, 69 publications were found. Of these, 15 met the established criteria and were used as the basis for this study. The results of this systematic review demonstrate that the measurement of serum levels of AMH in association with the population of antral follicles (FPA) is a promising parameter to estimate the reproductive potential of different domestic females. However, due to the lack of validation in large herds and the absence of reliable predictive values for each species, the potential of AMH is still underutilized.La hormona antimülleriana (AMH) ha ganado un interés creciente como biomarcador de la reserva folicular ovárica. Por lo tanto, el presente estudio tiene como objetivo presentar una revisión sistemática de los hallazgos recientes relacionados con la AMH, con énfasis en su papel como biomarcador de la reserva folicular ovárica en diferentes especies domésticas. Para eso, se realizaron búsquedas en bases de datos de bibliotecas científicas electrónicas, en busca de artículos que abordaran la presente temática. Los estudios encontrados fueron analizados y sometidos a criterios de inclusión y exclusión que permitieron seleccionar aquellos que cumplieron con los objetivos del presente estudio. En total, se encontraron 69 publicaciones. De estos, 15 cumplieron con los criterios establecidos y se utilizaron como base para este estudio. Los resultados de esta revisión sistemática demuestran que la medición de los niveles séricos de AMH en asociación con la población de folículos antrales (FPA) es un parámetro prometedor para estimar el potencial reproductivo de diferentes hembras domésticas. Sin embargo, debido a la falta de validación en grandes manadas y la ausencia de valores predictivos confiables para cada especie, el potencial de AMH aún está infrautilizado.O hormônio Anti-Mülleriano (AMH) tem ganhado interesse crescente como um biomarcador da reserva folicular ovariana. Portanto, o presente estudo tem como objetivo apresentar uma revisão sistemática sobre os achados recentes relacionados ao AMH, com ênfase no seu papel como biomarcador da reserva folicular ovariana em diferentes espécies domésticas. Para tanto, foram realizadas pesquisas em bases de dados de bibliotecas eletrônicas científicas, em busca de artigos que abordassem a presente temática. Os estudos encontrados foram analisados e submetidos a critérios de inclusão e exclusão que permitiram realizar a seleção daqueles que atendiam aos objetivos do presente estudo. No total, foram encontradas 69 publicações. Destas, 15 estavam de acordo com os critérios estabelecidos e foram utilizadas para o embasamento deste estudo. Os resultados desta revisão sistemática demonstram que a dosagem dos níveis séricos de AMH em associação com a população de folículos antrais (PFA) constitui um parâmetro promissor para estimar o potencial reprodutivo de diferentes fêmeas domésticas. Entretanto, devido à falta de validação em grandes rebanhos e ausência de valores preditivos confiáveis para cada espécie, o potencial do AMH ainda é subutilizado

Perspectivas epidemiológicas, clínicas e terapêuticas do transtorno bipolar em comorbidade com o uso de drogas: revisão de sistemática: Epidemiological, clinical and therapeutic perspectives of bipolar disorder in comorbidity with drug use: a systematic review

Conhecida como transtorno maníaco-depressivo, atualmente possui um novo nome: Transtorno Afetivo Bipolar, visto que com o passar do tempo foi se percebendo que esse transtorno não se tratava de uma alteração psicótica, e mais de um prejuízo afetivo. O transtorno bipolar possui alguns tipos, não se caracterizando em apenas uma forma, sua manifestação varia conforme o indivíduo e suas tendências, disforia e/ou euforia porém independente da forma expressa o paciente bipolar pode ter sua vida social comprometida, se não tratada, visto a irregularidade no estado de humor; bem como pode fazer uso de substâncias psicoativas, o que prejudica a sua condição clínica. Objetivo central da pesquisa é de apresentar a correlação do transtorno bipolar com o uso de drogas, mediante uma revisão de literatura integrativa realizada entre os meses de março de 2022 a julho de 2022, através da busca de artigos científicos nos bancos de dados online PubMed, Scielo e Google Acadêmico, utilizando como critério de refinamento de pesquisa artigos de todas as línguas publicados entre os anos 2000 e 2022

Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil

Abstract The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus across the country since its first detection in 2014 in Northeast Brazil. In this work, we carried out on-site training activities in genomic surveillance in partnership with the National Network of Public Health Laboratories that have led to the generation of 422 chikungunya virus genomes from 12 Brazilian states over the past two years (2021–2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. These genomes increased the amount of available data and allowed a more comprehensive characterization of the dispersal dynamics of the chikungunya virus East-Central-South-African lineage in Brazil. Tree branching patterns revealed the emergence and expansion of two distinct subclades. Phylogeographic analysis indicated that the northeast region has been the leading hub of virus spread towards other regions. Increased frequency of C > T transitions among the new genomes suggested that host restriction factors from the immune system such as ADAR and AID/APOBEC deaminases might be driving the genetic diversity of the chikungunya virus in Brazil

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora