832 research outputs found
Endocrine Factors, Retinal Vessels, and Risk of Dementia
First described 100 years ago by Alois Alzheimer, the clinico-pathological entity that we
now call Alzheimer disease was initially presented as a clinically unusual type of dementia.
1 Nowadays, Alzheimer disease is recognized as the main cause of dementia and one
of the most disabling and burdensome health conditions worldwide.2,3 The number of
people affected by dementia is estimated to double every 20 years to over 80 million by
2040.3 This will not only affect patients and their caregivers, but will also put an enormous
demand on health care and welfare resources
Dementia With Lewy Bodies A Clinicopathologic Series of False-positive Cases
Diagnosing dementia with Lewy bodies (DLB) is challenging as symptoms are heterogenous and not specific to the disease.
Here we present a clinicopathologic series of false-positive DLB
cases. Patients were enrolled retrospectively from the Netherlands
Brain Bank when they met the clinical criteria of probable DLB, but
with a pathologic diagnosis other than DLB or Parkinson’s disease
dementia. Twenty-two false-positive cases were selected. Alzheimer
disease with or without copathology was the most common (64%)
pathologic diagnosis. Other pathologic diagnoses, such as frontotemporal dementia, multiple-system atrophy, Creutzfeldt-Jakob disease, and autoimmune encephalitis, were also encountered. Atypical
clinical signs for DLB were present in almost half of the cases and
could be a trigger to consider other diagnoses than DLB. Additional
diagnostic examinations, feedback of pathologic diagnosis, and the
creation of a set of clinical features that are indicative of other conditions, could reduce the amount of false-positive DLB cases
Quantification of transpulmonary echocontrast effects
Videodensity of left heart and right heart were studied after intravenous injection of increasing dosages of 0.01-0.02 and 0.04 mL/kg bodyweight of Albunex® in 10 healthy volunteers. The increase in videodensity in the left ventricle was always lower than in the right ventricle. Possible explanations are diffusion of gases caused by ambient pressures changes and change in microspheres distribution due to the sieving effect of the lung capillary bed. These phenomena were studied in vitro and were consistent with clinical observations. These limitations restrict a quantitative assessment of left heart echocontrast after intravenous injection
Screening and guided self-help intervention for anxiety and depression in patients with type 2 diabetes
Mineralogy of oxygen-rich dust shells
Wetensch. publicatieFaculteit der Wiskunde en Natuurwetenschappe
Further detections of OH masers in carbon stars with silicate features
A sample of J-type carbon stars was searched for OH maser emission. The new
detection of three OH lines towards two silicate carbon stars is reported. In
V778 Cyg, previously known as the main-lines (1665 and 1667 MHz) maser source,
the satellite 1612 MHz emission was discovered while in NSV 2814 the main OH
lines were detected. The presence of OH maser lines confirms the former
suggestion that oxygen-rich material is located in the vicinity (
cm) of silicate carbon stars.Comment: LaTeX2e, 4 pages with 2 figure
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