Bose-stimulated scattering off a cold atom trap

The angle and temperature dependence of the photon scattering rate for Bose-stimulated atom recoil transitions between occupied states is compared to diffraction and incoherent Rayleigh scattering near the Bose-Einstein transition for an optically thin trap in the limit of large particle number, N. Each of these processes has a range of angles and temperatures for which it dominates over the others by a divergent factor as N->oo.Comment: 18 pages (REVTeX), no figure

Condensate fluctuations of a trapped, ideal Bose gas

For a non-self-interacting Bose gas with a fixed, large number of particles confined to a trap, as the ground state occupation becomes macroscopic, the condensate number fluctuations remain micrscopic. However, this is the only significant aspect in which the grand canonical description differs from canonical or microcanonical in the thermodynamic limit. General arguments and estimates including some vanishingly small quantities are compared to explicit, fixed-number calculations for 10^2 to 10^6 particles.Comment: 16 pages (REVTeX) plus 4 figures (ps), revision includes brief comparison of repulsive-interaction vs. fixed-N fluctuation damping. To be published in Phys. Rev.

Reproducing reality. Recreating bonding defects observed in transparent poly(methyl methacrylate) museum objects and assessing defect formation

The most common method chosen by artists, designers, and craftsmen to realize artworks and objects with transparent poly(methyl methacrylate) (PMMA) is to bond pieces from premanufactured sheets using solvents or adhesives. This method is considered relatively easy to use, however achieving bonds that are both transparent and strong can be difficult. Artifacts from museum collections made by bonding transparent PMMA often exhibit a variety of bonding defects and failures not yet addressed in depth in the conservation literature. Therefore, an international project started with the aims of classifying these bonding issues and understand their causes. This paper presents the results of the first part of this project which included the following research activities: surveys of bonding defects in PMMA artworks and design objects in museum collections, a literature review of the most recommended materials and methods used to bond PMMA over time, the preparation of bonded PMMA mock-ups based on literature review, chemical characterization of the bonding materials, thermal ageing of mock-ups, and finally technical examinations of the PMMA bonded mock-ups. The main defects observed in the museum objects surveyed were successfully recreated in the lab and the causes of their formation were assessed

The role of pancreatoscopy in the diagnostic work-up of intraductal papillary mucinous neoplasms : a systematic review and meta-analysis

Background Confirming the diagnosis, invasiveness, and disease extent of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas is challenging. The aim of this study was to summarize the literature on the efficacy and safety of peroral pancreatoscopy (POP) in the diagnosis of IPMN, including the impact of pre- and intraoperative POP on the management of IPMN. Methods The EMBASE, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar databases were systematically searched for articles. Eligible articles investigated cohorts of patients who underwent POP for (suspected) IPMN. Results 25 articles were identified and included in this review; with 22 of these reporting on the diagnostic yield of POP in IPMN and 11 reporting on the effect of pre- or intraoperative POP on clinical decision-making. Cannulation and observation rates, and overall diagnostic accuracy were high across all studies. Frequently reported visual characteristics of IPMN were intraductal fish-egg-like lesions, hypervascularity, and granular mucosa. Overall, the adverse event rate was 12 %, primarily consisting of post-endoscopic retrograde cholangiopancreatography pancreatitis, with a pooled rate of 10 %, mostly of mild severity. Regarding the impact of POP on clinical decision-making, POP findings altered the surgical approach in 13%- 62% of patients. Conclusion POP is technically successful in the vast majority of patients with (suspected) IPMN, has a consistently high diagnostic accuracy, but an adverse event rate of 12 %. Data on intraoperative pancreatoscopy are scarce, but small studies suggest its use can alter surgical management. Future studies are needed to better define the role of POP in the diagnostic work-up of IPMN.Peer reviewe

Mechanochemical action of the dynamin protein

Dynamin is a ubiquitous GTPase that tubulates lipid bilayers and is implicated in many membrane severing processes in eukaryotic cells. Setting the grounds for a better understanding of this biological function, we develop a generalized hydrodynamics description of the conformational change of large dynamin-membrane tubes taking into account GTP consumption as a free energy source. On observable time scales, dissipation is dominated by an effective dynamin/membrane friction and the deformation field of the tube has a simple diffusive behavior, which could be tested experimentally. A more involved, semi-microscopic model yields complete predictions for the dynamics of the tube and possibly accounts for contradictory experimental results concerning its change of conformation as well as for plectonemic supercoiling.Comment: 17 pages, 4 figures; typos corrected, reference adde

Hydrogen atom in a spherical well: linear approximation

We discuss the boundary effects on a quantum system by examining the problem of a hydrogen atom in a spherical well. By using an approximation method which is linear in energy we calculate the boundary corrections to the ground-state energy and wave function. We obtain the asymptotic dependence of the ground-state energy on the radius of the well.Comment: Revised version to appear in European Journal of Physic

Clinical experience with a novel subcutaneous implantable defibrillator system in a single center

Background: Implantable cardioverter-defibrillators (ICDs) reduce mortality in both primary and secondary prevention, but are associated with substantial short- and long-term morbidity. A totally subcutaneous ICD (S-ICD) system has been developed. We report the initial clinical experience of the first 31 patients implanted at our hospital. Methods: All patients had an ICD indication according to the ACC/AHA/ESC guidelines. The first 11 patients were part of the reported CE trial. The implantation was performed without fluoroscopy. The device was implanted subcutaneously in the anterior axillary line, with a parasternal lead tunneled from the xiphoid to the manubrial-sternal junction. Ventricular fibrillation (VF) was induced to assess detection accuracy and defibrillation efficacy using 65 J shocks. Results: Post-implant, 52 sustained episodes of VF were induced. Sensitivity was 100% and induced conversion efficacy was 100% (with standard polarity in 29 patients). Mean time to therapy was 13.9 ± 2.5 s (range 11-21.6 s). Late procedure-related complications were observed in 2 of the first 11 implantations (lead migration). During follow-up, spontaneous ventricular arrhythmias occurred in four patients, with accurate detection of all episodes. Inappropriate therapy was observed in five patients. Recurrences were prevented with reprogramming. Conclusions: The S-ICD system can be implanted without the use of fluoroscopy by using anatomical landmarks only. Episodes of VF were accurately detected using subcutaneous signals, and all induced and clinical episodes were successfully converted. The S-ICD system is a viable alternative to conventional ICD systems for selected patients

Fluctuation-Dissipation theorems and entropy production in relaxational systems

We show that for stochastic dynamical systems out of equilibrium the violation of the fluctuation-dissipation equality is bounded by a function of the entropy production. The result applies to a much wider situation than `near equilibrium', comprising diffusion as well as glasses and other macroscopic systems far from equilibrium. For aging systems this bounds the age-frequency regimes in which the susceptibilities satisfy FDT in terms of the rate of decay of the H-function, a question intimately related to the reading of a thermometer placed in contact with the system.Comment: 4 pages, RevTex; formula and reference added plus various minor changes in the tex