Prvi nalaz plavog raka Callinectes sapidus Rathbun, 1896 (Crustacea: Brachyura: Portunidae) u vodama pokrajine Abruzzi, srednji Jadran

For the first time, one female individual of blue crab Callinectes sapidus Rathbun, 1896, a species native to the western Atlantic coasts, is reported from Abruzzi waters (central Adriatic Sea). This species has widely invaded European Atlantic coasts and several areas of the Mediterranean, probably brought by ballast waters; yet, it has not settled in the study area.Po prvi put, jedinka ženke plavog raka Callinectes sapidus rathbun, 1896 vrste koja potječe sa zapadne obale atlantika, zabilježena je u vodama pokrajine abruzzi (srednji Jadran). Ova vrsta je uvelike najezdila europske obale atlantika i nekoliko područja u mediteranu, donešena vjerojatno balastnim vodama; ipak, još se nije u potpunosti nastanila u istraživanom području

Long-term follow-up of Philadelphia chromosome-positive (Ph+) chronic myeloid leukaemia (CML) in children and adolescents managed at a single institution over a 20-year period

Chronic myeloid leukaemia (CML) is rare in childhood. In our Institution we managed 30 consecutive Ph+CML patients aged <18 years, according to our adults’ guidelines. Patients with HLA-identical related donor (RD) underwent stem cell transplant (SCT). Since 1989, patients without RD were systematically treated with -interferon (IFN) (median dosage: 6 MU/day). Of 18/19 evaluable patients, 17 (94.5%) achieved haematologic response (HR), 11/17 (65%) cytogenetic response (CyR), complete (CCyR) in 4 (23.5%). Three patients remain in CCyR, 2 achieved BCR-ABL transcript disappearance. Of 13 patients without CCyR, 5 underwent SCT, 4 switched to STI571, 4 progressed. All patients receiving STI571 in chronic phase (CP) obtained sustained CCyR and 3 a persistent molecular response. 8-year survival among IFN-treated patients, censored or not for subsequent therapies, is 62% and 63%. Overall, 13/30 patients underwent SCT: 5 HLA-identical-RD, 5 matched unrelated donor, 2 mismatched-RD, 1 unrelated mismatched umbilical cord blood. Eight allotransplanted patients (6/6 in 1st CP) are in cytogenetic and molecular remission with 8-year survival of 61% from SCT and 69% from diagnosis. In our 20-year experience, the use of IFN in children without matched RD led to prolonged cytogenetic and molecular responses and long-term survival, without impairing the outcome of subsequent SCT

Desempenho de soja-hortaliça cultivada em área de cerrado em função de tipos de adubação. = Soybean pod agronomic performance as a function types of fertilization cultivated in the Savannah area of Roraima, Brazil.

Objetivou-se com este trabalho avaliar o desempenho de dois genótipos de soja-hortaliça em função de três tipos de adubação em dois anos de cultivo (2007-2008). O delineamento experimental foi de blocos casualizados em esquema de parcelas subdivididas, com cinco repetições. Nas parcelas foram aleatorizados os três tipos de adubação: (1) Convencional - adubação mineral com 100 kg ha-1 de P2O5 (superfosfato simples) e 90 kg ha-1 de K2O (cloreto de potássio); (2) Intermediário - adubação de base com 1.000 kg ha-1 de termofosfato magnesiano aplicado no sulco de semeadura + 50% do tratamento convencional (1); (3) Alternativo - aplicação de 1.000 kg ha-1 de termofosfato magnesiano aplicado no sulco de semeadura. Os genótipos BR9452273 e BRS 258 foram aleatorizados nas subparcelas. A subparcela experimental apresentava as dimensões de 2,0 x 2,0 m, com espaçamento de 0,40 m entre fileiras e dez plantas por metro, perfazendo uma população de 250.000 plantas ha-1. Avaliou-se a altura das plantas, produtividade de vagens verdes, número de vagens em 500 gramas, rendimento relativo de grãos verdes, umidade dos grãos, massa de 100 grãos verdes e secos, e estimativa da produtividade de grãos secos. Os resultados indicam o tratamento convencional com maior produção média de vagens verdes (11.184 kg ha-1), massa de 100 grãos (44,4 g), assim como a estimativa do rendimento de grãos secos (3.235 kg ha-1), no primeiro plantio, e no segundo plantio, os genótipos e as adubações não influenciam no rendimento de vagens verdes e a maior massa de 100 grãos é obtida com a BR9452273. = The objective of this study was to evaluated green pod productivity of two vegetable soybean cultivars under three types of fertilization, cultivated for two years (2007/2008). The experimental design was completely randomized blocks under a split plot scheme with five replications. Within plots three fertilization types were randomized: (1) Conventional - fertilization with 100 kg ha-1 of P2O5 and 90 kg ha-1 de K2O; (2) Intermediate - 1.000 kg ha-1 of magnesium thermophosphate at soybean sowing + 50% of conventional treatment; (3) Alternative - 1.000 kg ha-1 of magnesium thermophosphate at soybean sowing. The Genotypes BR9452273 and BRS 258 were randomized within subplot. The experimental subplot presented dimensions of 2 x 2 m, with 0,40 m between soybean rows and 10 plants per meter, resulting a population of 250.000 plants ha-1. The following parameters were evaluated: plant height, plant population, green pod productivity, number of pods in 500 g, greenpod relative yield, grain humidity and green and dry mass of 100 grains and estimated dry grain productivity. The results have shown that the conventional treatment revealed the most elevated average of green pod production (11184 kg ha-1), mass of 100 grains (44.4 g) as well as the estimate of dry grain productivity (3235 kg ha-1) concerning to first crop, and among the second crop, genotypes and fertilization did not affect green pod productivity and the higher mass for 100 grains was obtained with BR9452273

Beware the wrong way! A report on gastrografin inhalation

An 83-year-old man was admitted to the Emergency Department of St. Anna University Hospital, Cona, Italy, after he had inhaled diatrizoate (gastrografin), a well-known hyperosmolar contrast agent, during an X-ray of the upper gastrointestinal tract. The family physician recommended the patient to take the test in order to demonstrate a possible hiatal hernia. While swallowing gastrografin he had an esophageal spasm (detected at fluoroscopy), which led to the inhalation of the contrast agent. After the episode, he was completely asymptomatic, eupnoeic, and with a good peripheral oxygen saturation. The physical examination was unremarkable. A chest X-ray of the lungs showed accumulation of the contrast agent in the distal bronchial tree (arrows in Figure 1A and B), with the right part being more involved because of the straight orientation of the right bronchus

Estratégias de intervenção sensório-motora para crianças prematuras no cuidado intensivo neonatal: uma revisão sistemática / Sensory-motor intervention strategies for premature infants in neonatal intensive care: a systematic review

Background: Interventions that imitate the intrauterine environment can have beneficial effects on the development of premature infants. Purpose: The aim of the present literature review was to determine what sensory-motor stimulation techniques are administered to premature newborns in neonatal intensive care units and analyze the impact of these interventions on neuropsychomotor development. Methods: The SciELO, LILACS, PubMed, PEDro and Cochrane databases were searched for pertinent articles published between 2007 and 2018.  Results: Seventy-five articles were identified and 10 were included in the review. Different sensory-motor interventions are employed, the most widely used of which are tactile and acoustic stimuli. Such interventions generate both immediate and long-term benefits to neuropsychomotor development in this population. Implications: Premature newborns have the ability to interact with different environment and sensory-motor stimulation methods.  These interventions generate both immediate and long-term benefits to neuropsychomotor development in this population, leading to weight gain and other improvements, such as a reduction in pain in this population.PROSPERO register number: CRD42018098693

Bone response to a Ca- and P-enriched titanium surface obtained by anodization

This study evaluated bone response to a Ca- and P- enriched titanium (Ti) surface treated by a multiphase anodic spark deposition coating (BSP-AK). Two mongrel dogs received bilateral implantation of 3 Ti cylinders (4.1 x 12 mm) in the humerus, being either BSP-AK treated or untreated (machined - control). At 8 weeks postimplantation, bone fragments containing the implants were harvested and processed for histologic and histomorphometric analyses. Bone formation was observed in cortical area and towards the medullary canal associated to approximately 1/3 of implant extension. In most cases, in the medullary area, collagen fiber bundles were detected adjacent and oriented parallel to Ti surfaces. Such connective tissue formation exhibited focal areas of mineralized matrix lined by active osteoblasts. The mean percentages of bone-to-implant contact were 2.3 (0.0-7.2 range) for BSP-AK and 0.4 (0.0-1.3 range) for control. Although the Mann-Whitney test did not detect statistically significant differences between groups, these results indicate a trend of BSP-AK treated surfaces to support contact osteogenesis in an experimental model that produces low bone-to-implant contact values.O objetivo desse estudo foi avaliar a resposta do tecido ósseo à superfície de titânio (Ti) enriquecida com Ca e P obtida por anodização (BSP-AK). Três cilindros de Ti (4,1 x 12 mm) BSP-AK ou usinado (controle) foram implantados bilateralmente nos úmeros de dois cães de raça indefinida. Oito semanas após a implantação, os fragmentos ósseos contendo os implantes foram removidos e processados para análises histológica e histomorfométrica. A formação óssea foi observada na região cortical e no canal medular até aproximadamente um terço da extensão do implante. Na maioria dos casos, feixes de fibras colágenas dispostos paralelamente à superfície do implante foram observados na região medular. Nessa região observaram-se também áreas focais de formação de matriz mineralizada e osteoblastos ativos. Os implantes do grupo BSP-AK apresentaram média de contato osso-implante 2,3%, com medidas variando de 0,0 a 7,2% e os do grupo controle tiveram média 0,4%, com medidas variando de 0,0 a 1,3%. Apesar do teste de Mann-Whitney não mostrar diferença estatisticamente significante entre os grupos, nossos resultados indicaram uma tendência para a ocorrência de osteogênese de contato na superfície BSP-AK em um modelo experimental que resulta em baixos valores de contato osso-implante.FAPES