1,115 research outputs found

    Trabalhadores Usuários De Drogas Em Recuperação Em Uma Região Industrial Do Brasil

    Get PDF
    Context: The number of illicit drug users worldwide is estimated at 210 million people annually, of which at least 200,000 die as a result. Drug abuse affects not only the user but also their family, friends, coworkers, and community. Objective: This study outlines a sociodemographic profle of workers undergoing treatment for chemical dependency recovery in Campinas (SP). Method: Cross-sectional, exploratory study with data collected in rehabilitation centers for chemical dependency treatment in Campinas by means of a self-administered and anonymous questionnaire. The research was conducted between July 2011 and July 2012 and focused on the analysis of health and work conditions. The study included workers who were followed for more than 30 days (n=200). Results: 87.8% of the population were aged 18-54 years. Most of them had completed high school, had an income of some kind, and of which 54.5% were formally employed. 48.4% hadcontract positions of less than one year and 42.1% had a salary range below R$1,020.00 (Brazilian real). Conclusion: This study provides information not explored in other studies and has a potential value related to the prevention, treatment, and rehabilitation of workers in similar conditions.142788

    Effects of the Energy Error Distribution of Fluorescence Telescopes on the UHECR energy spectrum

    Full text link
    The measurement of the ultra high energy cosmic ray (UHECR) spectrum is strongly affected by uncertainties on the reconstructed energy. The determination of the presence or absence of the GZK cutoff and its position in the energy spectrum depends not only on high statistics but also on the shape of the energy error distribution. Here we determine the energy error distribution for fluorescence telescopes, based on a Monte Carlo simulation. The HiRes and Auger fluorescence telescopes are simulated in detail. We analyze the UHECR spectrum convolved with this energy error distribution. We compare this spectrum with one convolved with a lognormal error distribution as well as with a Gaussian error distribution. We show that the energy error distribution for fluorescence detectors can not be represented by these known distributions. We conclude that the convolved energy spectrum will be smeared but not enough to affect the GZK cutoff detection. This conclusion stands for both HiRes and Auger fluorescence telescopes. This result differs from the effect of the energy error distribution obtained with ground detectors and reinforces the importance of the fluorescence energy measurement. We also investigate the effect of possible fluorescence yield measurement errors in the energy spectrum.Comment: 24 pages, 11 figure

    Localization Of Metastasis Within The Sentinel Lymph Node Biopsies: A Predictor Of Additional Axillary Spread Of Breast Cancer? [localização Da Metástase No Interior Dos Linfonodos Sentinelas: Um Preditor De Disseminação Adicional Axilar Em Câncer De Mama?]

    Get PDF
    Purpose: To explore the relationship between morphological characteristics and histologic localization of metastasis within sentinel lymph nodes (SLN) and axillary spread in women with breast cancer. Methods: We selected 119 patients with positive SLN submitted to complete axillary lymph node dissection from July 2002 to March 2007. We retrieved the age of patients and the primary tumor size. In the primary tumor, we evaluated histologic and nuclear grade, and peritumoral vascular invasion (PVI). In SLNs we evaluated the size of metastasis, their localization in the lymph node, number of foci, number of involved lymph nodes, and extranodal extension. Results: Fifty-one (42.8%) patients had confirmed additional metastasis in non-sentinel lymph nodes (NLSN). High histologic grade, PVI, intraparenchymatous metastasis, extranodal neoplastic extension and size of metastasis were associated with positive NLSN. SLN metastasis affecting the capsule were associated to low risk incidence of additional metastasis. After multivariate analysis, PVI and metastasis size in the SLN remained as the most important risk factors for additional metastasis. Conclusions: The risk of additional involvement of NSLN is higher in patients with PVI and it increases progressively according the histologic localization in the lymph node, from capsule, where the afferent lymphatic channel arrives, to the opposite side of capsule promoting the extranodal extension. Size of metastasis greater than 6.0 mm presents higher risk of additional lymph node metastasis.3511483489Giuliano, A.E., Mapping a pathway for axillary staging: A personal perspective on the current status of sentinel lymph node dissection for breast cancer (1999) Arch Surg., 134 (2), pp. 195-199Ernst, M.F., Voogd, A.C., Balder, W., Klinkenbijl, J.H., Roukema, J.A., Early and late morbidity associated with axillary levels I-III dissection in breast cancer (2002) J Surg Oncol., 79 (3), pp. 151-155Edge, S.B., Niland, J.C., Bookman, M.A., Theriault, R.L., Ottesen, R., Lepisto, E., Emergence of sentinel node biopsy in breast cancer as standard-of-care in academic comprehensive cancer centers (2003) J Natl Cancer Inst., 95 (20), pp. 1514-1521Noguchi, M., Sentinel lymph node biopsy as an alternative to routine axillary lymph node dissection in breast cancer patients (2001) J Surg Oncol., 76 (2), pp. 144-156Veronesi, U., Paganelli, G., Viale, G., Luini, A., Zurrida, S., Galimberti, V., A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer (2003) N Engl J Med., 349 (6), pp. 546-553Fisher, B., Anderson, S., Bryant, J., Margolese, R.G., Deutsch, M., Fisher, E.R., Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer (2002) N Engl J Med., 347 (16), pp. 1233-1241Giuliano, A.E., Hunt, K.K., Ballman, K.V., Beitsch, P.D., Whitworth, P.W., Blumencranz, P.W., Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: A randomized clinical trial (2011) JAMA., 305 (6), pp. 569-575Giuliano, A.E., Kirgan, D.M., Guenther, J.M., Morton, D.L., Lymphatic mapping and sentinel lymphadenectomy for breast cancer (1994) Ann Surg., 220 (3), pp. 391-401Czerniecki, B.J., Scheff, A.M., Callans, L.S., Spitz, F.R., Bedrosian, I., Conant, E.F., Immunohistochemistry with pancytokeratins improves the sensitivity of sentinel lymph node biopsy in patients with breast carcinoma (1999) Cancer., 85 (5), pp. 1098-1103Albertini, J.J., Lyman, G.H., Cox, C., Yeatman, T., Balducci, L., Ku, N., Lymphatic mapping and sentinel node biopsy in the patient with breast cancer (1996) JAMA., 276 (22), pp. 1818-1822Veronesi, U., Paganelli, G., Galimberti, V., Viale, G., Zurrida, S., Bedoni, M., Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes (1997) Lancet., 349 (9069), pp. 1864-1867Kamath, V.J., Giuliano, R., Dauway, E.L., Cantor, A., Berman, C., Ku, N.N., Characteristics of the sentinel lymph node in breast cancer predict further involvement of higher-echelon nodes in the axilla: A study to evaluate the need for complete axillary lymph node dissection (2001) Arch Surg., 136 (6), pp. 688-692Veronesi, U., Paganelli, G., Viale, G., Galimberti, V., Luini, A., Zurrida, S., Sentinel lymph node biopsy and axillary dissection in breast cancer: Results in a large series (1999) J Natl Cancer Inst., 91 (4), pp. 368-373Van Zee, K.J., Manasseh, D.M., Bevilacqua, J.L., Boolbol, S.K., Fey, J.V., Tan, L.K., A nomogram for predicting the likelihood of additional nodal metastases in breast cancer patients with a positive sentinel node biopsy (2003) Ann Surg Oncol., 10 (10), pp. 1140-1151Cserni, G., Boross, G., Maráz, R., Leidenius, M.H., Meretoja, T.J., Heikkila, P.S., Multicentre validation of different predictive tools of non-sentinel lymph node involvement in breast cancer (2012) Surg Oncol., 21 (2), pp. 59-65(2010) AJCC Cancer Staging Manual, , American Joint Committee on Cancer. 7th ed. New York: Springer VerlagElston, C.W., Ellis, I.O., Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up (1991) Histopathology., 19 (5), pp. 403-410Carcoforo, P., Maestroni, U., Querzoli, P., Lanzara, S., Maravegias, K., Feggi, L., Primary breast cancer features can predict additional lymph node involvement in patients with sentinel node micrometastases (2006) World J Surg., 30 (9), pp. 1653-1657Fougo, J.L., Afonso, M., Senhorães Senra, F., Dias, T., Leal, C., Araújo, C., Predictive factors for non-sentinel lymph node involvement in breast cancer patients with a positive sentinel node: Should we consider sentinel node-related factors? (2009) Clin Transl Oncol., 11 (3), pp. 165-171Hwang, R.F., Krishnamurthy, S., Hunt, K.K., Mirza, N., Ames, F.C., Feig, B., Clinicopathologic factors predicting involvement of nonsentinel axillary nodes in women with breast cancer (2003) Ann Surg Oncol., 10 (3), pp. 248-254Mustać, E., Matusan-Ilijas, K., Marijić, B., Smokvina, M., Jonjić, N., Predicting the likelihood of additional nodal metastases in breast carcinoma patients with positive sentinel node biopsy (2010) Int J Surg Pathol., 18 (1), pp. 36-41Viale, G., Maiorano, E., Pruneri, G., Mastropasqua, M.G., Valentini, S., Galimberti, V., Predicting the risk for additional axillary metastases in patients with breast carcinoma and positive sentinel lymph node biopsy (2005) Ann Surg., 241 (2), pp. 319-325Bolster, M.J., Peer, P.G., Bult, P., Thunnissen, F.B., Schapers, R.F., Meijer, J.W., Risk factors for non-sentinel lymph node metastases in patients with breast cancer. The outcome of a multi-institutional study (2007) Ann Surg Oncol., 14 (1), pp. 181-189Bernardi, S., Bertozzi, S., Londero, A.P., Giacomuzzi, F., Angione, V., Dri, C., Nine years of experience with the sentinel lymph node biopsy in a single Italian center: A retrospective analysis of 1,050 cases (2012) World J Surg., 36 (4), pp. 714-722Abdessalam, S.F., Zervos, E.E., Prasad, M., Farrar, W.B., Yee, L.D., Walker, M.J., Predictors of positive axillary lymph nodes after sentinel lymph node biopsy in breast cancer (2001) Am J Surg., 182 (4), pp. 316-320Chu, K.U., Turner, R.R., Hansen, N.M., Brennan, M.B., Bilchik, A., Giuliano, A.E., Do all patients with sentinel node metastasis from breast carcinoma need complete axillary node dissection? (1999) Ann Surg., 229 (4), pp. 536-541Fleming, F.J., Kavanagh, D., Crotty, T.B., Quinn, C.M., McDermott, E.W., O'Higgins, N., Factors affecting metastases to non-sentinel lymph nodes in breast cancer (2004) J Clin Pathol., 57 (1), pp. 73-76Joseph, K.A., El-Tamer, M., Komenaka, I., Troxel, A., Ditkoff, B.A., Schnabel, F., Predictors of nonsentinel node metastasis in patients with breast cancer after sentinel node metastasis (2004) Arch Surg., 139 (6), pp. 648-651Wong, S.L., Edwards, M.J., Chao, C., Tuttle, T.M., Noyes, R.D., Woo, C., Predicting the status of the nonsentinel axillary nodes: A multicenter study (2001) Arch Surg., 136 (5), pp. 563-568Zavagno, G., De Salvo, G.L., Bozza, F., Scalco, G., Marconato, R., Valletta, S., Number of metastatic sentinel nodes as predictor of axillary involvement in patients with breast cancer (2004) Breast Cancer Res Treat., 86 (2), pp. 171-179Meretoja, T.J., Vironen, J.H., Heikkilä, P.S., Leidenius, M.H., Outcome of selected breast cancer patients with micrometastasis or isolated tumor cells in sentinel node biopsy and no completion axillary lymph node dissection (2010) J Surg Oncol., 102 (3), pp. 215-219Ozcinar, B., Muslumanoglu, M., Igci, A., Gurdal, S.O., Yavuz, E., Kecer, M., Clinical importance of micrometastasis in sentinel lymph nodes (2011) Breast., 20 (1), pp. 31-33Turner, R.R., Chu, K.U., Qi, K., Botnick, L.E., Hansen, N.M., Glass, E.C., Pathologic features associated with nonsentinel lymph node metastases in patients with metastatic breast carcinoma in a sentinel lymph node (2000) Cancer., 89 (3), pp. 574-581Sachdev, U., Murphy, K., Derzie, A., Jaffer, S., Bleiweiss, I.J., Brower, S., Predictors of nonsentinel lymph node metastasis in breast cancer patients (2002) Am J Surg., 183 (3), pp. 213-217Reynolds, C., Mick, R., Donohue, J.H., Grant, C.S., Farley, D.R., Callans, L.S., Sentinel lymph node biopsy with metastasis: Can axillary dissection be avoided in some patients with breast cancer? (1999) J Clin Oncol., 17 (6), pp. 1720-1726Diaz, L.K., Hunt, K., Ames, F., Meric, F., Kuerer, H., Babiera, G., Histologic localization of sentinel lymph node metastases in breast cancer (2003) Am J Surg Pathol., 27 (3), pp. 385-389Paish, E.C., Green, A.R., Rakha, E.A., McMillan, R.D., Maddison, J.R., Ellis, I.O., Three-dimensional reconstruction of sentinel lymph nodes with metastatic breast cancer indicates three distinct patterns of tumour growth (2009) J Clin Pathol., 62 (7), pp. 617-62

    Probing neutrino properties with charged scalar lepton decays

    Get PDF
    Supersymmetry with bilinear R-parity violation provides a predictive framework for neutrino masses and mixings in agreement with current neutrino oscillation data. The model leads to striking signals at future colliders through the R-parity violating decays of the lightest supersymmetric particle. Here we study charged scalar lepton decays and demonstrate that if the scalar tau is the LSP (i) it will decay within the detector, despite the smallness of the neutrino masses, (ii) the relative ratio of branching ratios Br({tilde tau}_1 --> e sum nu_i)/ Br({tilde tau}_1 --> mu sum nu_i) is predicted from the measured solar neutrino angle, and (iii) scalar muon and scalar electron decays will allow to test the consistency of the model. Thus, bilinear R-parity breaking SUSY will be testable at future colliders also in the case where the LSP is not the neutralino.Comment: 24 pages, 8 ps figs Report-no.: IFIC/02-33 and ZU-TH 11/0
    corecore