63 research outputs found
Influence of the nucleobase on the physicochemical characteristics and biological activities of SbV-ribonucleoside complexes
The influence of the nucleobase (uracyl, U; cytosine, C; adenine, A; guanine, G) on the physicochemical characteristics and in vitro biological activities of SbV-ribonucleoside complexes has been investigated. The 1:1 Sb-U and Sb-C complexes were characterized by NMR and ESI-MS spectroscopies and elemental analysis. The stability constant and the apparent association and dissociation rate constants of 1:1 SbV-U, SbV-C and SbV-A complexes were determined. Although SbV most probably binds via oxygen atoms to the same 2' and 3' positions in the different nucleosides, the ribose conformational changes and the physicochemical characteristics of the complex depend on the nucleobase. The nucleobase had a strong influence on the cytotoxicity against macrophages and the antileishmanial activity of the SbV-ribonucleoside complexes. The SbV-purine complexes were more cytotoxic and more effective against Leishmania chagasi than the SbV-pyrimidine complexes, supporting the model that the interaction of SbV with purine nucleosides may mediate the antileishmanial activity of pentavalent antimonial drugs
Desenvolvendo a competĂȘncia informacional: a experiĂȘncia do curso de Biblioteconomia da UFPA com egressos do sistema penal e familiares atendidos pela FĂĄbrica Esperança
Expanding tropical forest monitoring into Dry Forests: The DRYFLOR protocol for permanent plots
This is the final version. Available on open access from Wiley via the DOI in this recordSocietal Impact Statement
Understanding of tropical forests has been revolutionized by monitoring in permanent plots. Data from global plot networks have transformed our knowledge of forestsâ diversity, function, contribution to global biogeochemical cycles, and sensitivity
to climate change. Monitoring has thus far been concentrated in rain forests. Despite
increasing appreciation of their threatened status, biodiversity, and importance to the
global carbon cycle, monitoring in tropical dry forests is still in its infancy. We provide
a protocol for permanent monitoring plots in tropical dry forests. Expanding monitoring into dry biomes is critical for overcoming the linked challenges of climate change,
land use change, and the biodiversity crisis.Newton FundNatural Environment Research Council (NERC)Fundação de Amparo à Pesquisa do Estado de São PauloCYTE
Os conhecimentos tradicionais dos(as) erveiros(as) da Feira do Ver-o-Peso (BelĂ©m, ParĂĄ, Brasil): um olhar sob a Ăłtica da CiĂȘncia da Informação
Cooperação cientĂfica internacional: estilos de atuação da Fundação Rockefeller e da Fundação Ford
Efeito da irrigação e adubação na disponibilidade e composição bromatológica da massa seca de lùminas foliares de capim-elefante
Determinantes de estrutura de capital no mercado brasileiro: anĂĄlise de regressĂŁo com painel de dados no perĂodo 1999-2003
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