Prevention and non-pharmacological management of pain in newborns

Objective: to describe the main non-pharmacological interventions for pain relief in newborns available in Neonatal Intensive Care Unit. Method: an exploratory search of the MedLine, Lilacs and Scielo online databases was conducted to retrieve references of studies published from 2004 to 2013. Results: several non-pharmacological interventions were shown to be effective, to represent low risk for neonates and to have a low operational cost. The ones most often discussed in the literature were: oral administration of glucose/sucrose, non-nutritive sucking, breastfeeding, skin-to-skin contact, facilitated tucking and swaddling. Conclusion: healthcare teams should be familiar with these methods and use them more effectively in Neonatal Intensive Care Unit daily routines, so as to ensure that newborns receive qualified and more human care

Induction of Immunological Tolerance by Oral Anti-CD3

In recent years, our knowledge about immunoregulation and autoimmunity has significantly advanced, but nontoxic and more effective treatments for different inflammatory and autoimmune diseases are still lacking. Oral tolerance is of unique immunologic importance because it is a continuous natural immunologic event driven by exogenous antigen and is an attractive approach for treatment of these conditions. Parenteral administration of anti-CD3 monoclonal antibody is an approved therapy for transplantation in humans and is effective in autoimmune diabetes. Orally administered anti-CD3 monoclonal antibody is biologically active in the gut and suppresses experimental models of autoimmune diseases. Orally delivered antibody does not have side effects including cytokine release syndromes, thus oral anti-CD3 antibody is clinically applicable for chronic therapy. Here we review findings that identify a novel and powerful immunologic approach that is widely applicable for the treatment of human autoimmune conditions

Competição de cultivares de milho (Zea mays L.) no Estado de Sergipe.

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Sistemas de cultivo para rendimento elevado em trigo e o desafio das correlações indesejadas.

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Estudos de Solos do Município de Aceguá, RS

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First records of 13 echinoderm species on the southwest coast of Portugal

En el ámbito de un análisis de caracterización del área marina adyacente al Parque Natural do Sudoeste Alentejano y Costa Vicentina (PNSACV) se ha estudiado material biológico diverso proveniente de campañas del programa SEPLAT (SEdimentos de la PLATaforma), del que es responsable el Instituto Hidrográfico de la Marina Portuguesa. Las muestras se obtuvieron en el área de plataforma continental adyacente al PNSACV, entre Sines y el cabo de San Vicente, a profundidades comprendidas entre los 15 y los 387 metros. Los equinodermos constituyeron, en esas campañas, un grupo bien representativo de la fauna marina presente en esta área de la plataforma continental. Se recogieron 60 especies de equinodermos distribuidos en las clases siguientes: 2 Crinoidea, 2 Asteroidea, 32 Ophiuroidea, 12 Echinoidea y 12 Holothurioidea. Trece de las 60 especies tienen aquí su primera cita para la costa portuguesa.As part of a characterisation study of the marine area contiguous to the Sudoeste Alentejano e Costa Vicentina Natural Park (PNSACV), biological material proceeding from cruises of the SEPLAT (PLATform SEdiments) programme (Portuguese Navy's Hydrographic Institute) has been studied. The sampling took place on the continental shelf contiguous to the PNSACV, between Sines and Cape St Vicente, at water depths ranging from 15-387 m. During these cruises, equinoderms were found to be a well-represented faunal group. Sixty echinoderm species were identified, distributed as follows, by classes: 2 crinoids, 2 asteroids, 32 ophiuroids, 12 equinoids and 12 holothuroids. Thirteen of the 60 species are first records on the Portuguese coast.Instituto Español de Oceanografí