Circularly polarized-thermally activated delayed fluorescent materials based on chiral bicarbazole donors

G. P. thanks the SCBM, the “PTC du CEA” (POLEM) and the ANR (iChiralight, ANR-19-CE07-0040) for funding and David Buisson, Amélie Goudet and Sabrina Lebrequier. J. C. and L. Fa. acknowledge the Ministère de l’Education Nationale, de la Recherche et de la Technologie, the CNRS and the Spectroscopies-CDTP core facility is also acknowledged. The St. Andrews team thanks the China Scholarship Council, 201906250199 to W. S. and 202006250026 to J. W., E. Z.-C. is a Royal Society Leverhulme Trust Senior Research fellow (SRF\R1\201089). We thank the EPSRC (EP/R035164/1) for funding.We describe herein a molecular design to generate circularly polarized thermally activated delayed fluorescence emitters in which chiral bicarbazole donors are connected to acceptor units via a rigid 8-membered cycle and how the nature of the donor and acceptor units affect the photophysical and chiroptical properties.Publisher PDFPeer reviewe

Carbon dioxide radical anion by photoinduced equilibration between formate salts and [ 11^{11}C, 13^{13}C, 14^{14}C]CO2_2 : application to carbon isotope radiolabeling

International audienceThe need for carbon-labeled radiotracers is increasingly higher in drug discovery and development (carbon-14, $\beta^-$, t$_{1/2}$ = 5730 years) as well as in PET, for in vivo molecular imaging applications (carbon-11, $\beta^+$ , t$_{1/2}$ = 20.4 min). However, the structural diversity of radiotracers is still systematically driven by the narrow available labeled sources and methodologies. In this context, the emergence of carbon dioxide radical anion chemistry might set forth potential unexplored opportunities. Based on a dynamic isotopic equilibration between formate salts and [ $^{13}$C, $^{14}$C, $^{11}$C]CO$_2$ , C-labeled radical anion CO$_2$$^{•-}$could be accessed under extremely mild conditions within seconds. This methodology was successfully applied to hydro-carboxylation and di-carboxylation reactions in late-stage carbon isotope labeling of pharmaceutically relevant compounds. The relevance of the method in applied radiochemistry was showcased by the whole-body PET biodistribution profile of [ $^{11}$C] oxaprozin in mice

Circularly polarized-thermally activated delayed fluorescent materials based on chiral bicarbazole donors

We describe herein a molecular design to generate circularly polarized thermally activated delayed fluorescence emitters in which chiral bicarbazole donors are connected to acceptor units via a rigid 8-membered cycle and how the nature of the donor and acceptor units affect the photophysical and chiroptical properties