23 research outputs found
Prophylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation
Prognostic value of reduced heart rate variability after myocardial infarction: clinical evaluation of a new analysis method.
Normal Electrophysiological Findings in a Patient with Symptomatic Intermittent Advanced Atrioventricular Block
Cardiac and whole body [3H]noradrenaline kinetics in ischaemic heart disease: contrast between unstable anginal syndromes and pacing induced ischaemia.
Cardiac anticholinergic effects of procainamide and its N-acelylated metabolite: experimental pharmacological and radioligand binding studies
Effect of intravenous adrenaline on electrocardiogram, blood pressure, and serum potassium.
Increased catecholamines after myocardial infarction may contribute to the development of arrhythmias. We have infused adrenaline intravenously in nine normal volunteers to levels similar to those seen after myocardial infarction. Adrenaline caused an increase in systolic blood pressure, a decrease in diastolic blood pressure, and an increase in heart rate. Adrenaline also produced a decrease in T wave amplitude and an increase in the QTc interval. The serum potassium fell dramatically during the adrenaline infusion from a control value of 4.06 mmol/l to 3.22 mmol/l. Hypokalaemia after myocardial infarction is associated with an increased incidence of ventricular arrhythmias. Thus, circulating adrenaline may increase the frequency of arrhythmias both directly via changes in ventricular repolarisation and indirectly via adrenaline induced hypokalaemia