72 research outputs found
Phenomenology of the nMSSM from colliders to cosmology
Low energy supersymmetric models provide a solution to the hierarchy problem
and also have the necessary ingredients to solve two of the most outstanding
issues in cosmology: the origin of dark matter and baryonic matter. One of the
most attractive features of this framework is that the relevant physical
processes are related to interactions at the weak scale and therefore may be
tested in collider experiments in the near future. This is true for the Minimal
Supersymmetric Standard Model (MSSM) as well as for its extension with the
addition of one singlet chiral superfield, the so-called nMSSM. It has been
recently shown that within the nMSSM an elegant solution to both the problem of
baryogenesis and dark matter may be found, that relies mostly on the mixing of
the singlet sector with the Higgs sector of the theory. In this work we review
the nMSSM model constraints from cosmology and present the associated collider
phenomenology at the LHC and the ILC. We show that the ILC will efficiently
probe the neutralino, chargino and Higgs sectors, allowing to confront
cosmological observations with computations based on collider measurements. We
also investigate the prospects for a direct detection of dark matter and the
constraints imposed by the current bounds of the electron electric dipole
moment in this model.Comment: 44 pp, 10 figures; Fig.9 replaced; discussion on CP violation
extended and references added; few minor additions in text about details of
the cut
Effects of early myocardial reperfusion and perfusion on myocardial necrosis/dysfunction and inflammation in patients with ST-segment and non-ST-segment elevation acute coronary syndrome : results from the PLATelet inhibition and patients Outcomes (PLATO) trial
Aims
Restoration of myocardial blood flow and perfusion during percutaneous coronary intervention (PCI) measured using Thrombolysis in Myocardial Infarction (TIMI) flow grade (TFG) and perfusion grade (TMPG) is associated with improved outcomes in acute coronary syndrome (ACS). Associations between TFG/TMPG and changes in biomarkers reflecting myocardial damage/dysfunction and inflammation is unknown.
Methods and results
Among 2606 patients included, TFG was evaluated in 2198 and TMPG in 1874 with ST-segment elevation myocardial infarction (STEMI) or non-ST-segment ACS (NSTE-ACS). Biomarkers reflecting myocardial necrosis [troponin T (TnT)], myocardial dysfunction [N-terminal prohormone brain natriuretic peptide (NT-proBNP)], inflammation [interleukin-6 (IL-6) and C-reactive protein (CRP)], and oxidative stress/ageing/inflammation [growth differentiation factor-15 (GDF-15)] were measured at baseline, discharge, and 1- and 6-month post-randomization. Associations between TFG/TMPG and changes in biomarker levels were evaluated using the Mann–Whitney–Wilcoxon signed test. In total, 1423 (54.6%) patients had STEMI and 1183 (45.4%) NSTE-ACS. Complete reperfusion after PCI with TFG = 3 was achieved in 1110 (85.3%) with STEMI and in 793 (88.5%) with NSTE-ACS. Normal myocardial perfusion with TMPG = 3 was achieved in 475 (41.6%) with STEMI and in 396 (54.0%) with NSTE-ACS. Levels of TnT, NT-proBNP, IL-6, CRP, and GDF-15 were substantially lower at discharge in patients with complete vs. incomplete TFG and STEMI (P < 0.01). This pattern was not observed for patients with NSTE-ACS. Patients with normal vs. abnormal TMPG and NSTE-ACS had lower levels of NT-proBNP at discharge (P = 0.01).
Conclusions
Successful restoration of epicardial blood flow in STEMI was associated with less myocardial necrosis/dysfunction and inflammation. Attainment of normal myocardial perfusion was associated with less myocardial dysfunction in NSTE-ACS
Influence of Copper Addition and Temperature on the Kinetics of Austempering in Ductile Iron
Gap Dependent Bifurcation Behavior of a Nano-Beam Subjected to a Nonlinear Electrostatic Pressure
An Accurate Study on Capacitive Microphone with Circular Diaphragm Using a Higher Order Elasticity Theory
The primitive idempotents of a cyclic group algebra, II
Explicit expressions are obtained for the complete set of primitive idempotents in FG, the semisimple group algebra of the cyclic group G of order 2n (n = 2) over the finite field F of prime power order q(odd), when q has order f(2n)/2 modulo 2
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