Prognostic significance of E-cadherin, β-catenin and cyclin D1 in oral squamous cell carcinoma: a tissue microarray study

Objective. To study the prognostic significance of E-cadherin, β-catenin, and cyclin D1 expression in oral squamous cell carcinoma. Subjects and Methods. The study included 65 subjects with histologically confirmed squamous cell carcinoma. TMA blocks were prepared for immunohistochemical quantification of the expression of the three markers using IHC profiler and Immune ratio plugin of Image J. Results. E-cadherin expression was significantly correlated with histological grades and the metastasis status (p<0.05), whereas β-catenin expression was significantly correlated with smoking and tumor recurrence (P<0.05). Cyclin D1 expression was significantly correlated with depth of invasion and tumor recurrence. (p<0.05). Advanced tumor stage and depth of tumor invasion increases the risk of recurrence or death by 2.5 times (OR=2.53 and 0.84 respectively). Conclusion. High expression of β-catenin and cyclin D1 are significantly correlated with tumor recurrence and old age. Depth of invasion, low histological grade and old age were a significant predictor for the risk of having tumor recurrence and cancer related death

Dense urbanism and economic multi-centrism at third-millennium BC Lagash

Studies of ancient Mesopotamian cities have long focused on their institutions. Here, instead, the authors draw on recent investigations at the third-millennium BC site of Lagash (modern Tell al-Hiba, Iraq) to explore urban density, economy and sustainability at one of the largest ancient urban centres of the region. Drawing on excavation, environmental and remote-sensing data, the authors adopt a multiscalar approach, revealing dense urban occupation, with subdivision into distinct walled quarters, as well as evidence for multiple foci of intensive industrial production and the exploitation of a rich mosaic of surrounding micro-environments. The study emphasises how a combination of new field data and alternative research directions offers novel insights into early urbanism

Dense urbanism and economic multi-centrism at third-millennium BC Lagash

Studies of ancient Mesopotamian cities have long focused on their institutions. Here, instead, the authors draw on recent investigations at the third-millennium BC site of Lagash (modern Tell al-Hiba, Iraq) to explore urban density, economy and sustainability at one of the largest ancient urban centres of the region. Drawing on excavation, environmental and remote-sensing data, the authors adopt a multi-scalar approach, revealing dense urban occupation, with subdivision into distinct walled quarters, as well as evidence for multiple foci of intensive industrial production and the exploitation of a rich mosaic of surrounding micro-environments. The study emphasises how a combination of new field data and alternative research directions offers novel insights into early urbanism