Reação adaptativa do sistema simpático de adrenalina de meninas em atividade física

The study of the functional state of the sympatho-adrenal system in girls of 11-16 years old undergoing graduated physical activity was performed on the basis of excretion rates of epinephrine, norepinephrine, dopamine and DOPA. As a functional test, a graduated cycloergometric load of 50% of the individually determined PWC170 was used. The results obtained made it possible to establish the heterochronic nature of the maturation of the hormonal and mediator links of the sympathetic adrenal system. The highest reactivity of the adrenal link of SAS is observed in girls of 12 years old, the lowest – in senior schoolgirls (15-16 years old). In girls of 12-13 years old, the reaction of urgent adaptation to the graduated physical activity is carried out against a background of high excretion of epinephrine (E), norepinephrine (NE), but without sufficient replenishment of the reserve capabilities of SAS, which is confirmed by minimal shifts in the excretion of dopamine (DA) and DOPA in these age groups. At 14-16 years, moderate shifts of E and NE as a reaction to activity are noted against the background of a significant increase in the excretion of precursors, which characterizes the SAS response to the functional test as more saving, with increasing reserve capacities.El estudio del estado funcional del sistema simpato-adrenal en niñas de 11-16 años sometidas a actividad física graduada se realizó sobre la base de las tasas de excreción de epinefrina, norepinefrina, dopamina y DOPA. Como prueba funcional, se utilizó una carga cicloergométrica graduada del 50% de la PWC170 determinada individualmente. Los resultados obtenidos permitieron establecer la naturaleza heterócrona de la maduración de los enlaces hormonales y mediadores del sistema adrenal simpático. La mayor reactividad del enlace suprarrenal de SAS se observa en niñas de 12 años, la más baja - en niñas de escuela secundaria (15-16 años). En niñas de 12-13 años de edad, la reacción de adaptación urgente a la actividad física gradual se lleva a cabo en un contexto de alta excreción de epinefrina (E), norepinefrina (NE), pero sin un reabastecimiento suficiente de las capacidades de reserva de SAS. que se confirma por cambios mínimos en la excreción de dopamina (DA) y DOPA en estos grupos de edad. A los 14-16 años, se observan cambios moderados de E y NE como reacción a la actividad en el contexto de un aumento significativo en la excreción de precursores, que caracteriza la respuesta SAS a la prueba funcional como más ahorro, con el aumento de la capacidad de reserva.O estudo do estado funcional das raparigas do sistema simpático-envelhecido 11-16 anos, submetidos a actividade física realizada classificados com base em taxas de excreção de epinefrina, norepinefrina, dopamina e DOPA. Como teste funcional, utilizou-se uma carga cicloergométrica graduada de 50% do PWC170 individualmente determinado. Os resultados obtidos permitiram estabelecer a natureza heterocrônica da maturação dos laços hormonais e mediadores do sistema adrenal simpático. A reatividade mais alta do elo adrenal de SAS observa-se em meninas de 12 anos, o mais baixo - em meninas de escola secundária (15-16 anos). Em raparigas com idades entre 12-13, reacção urgente de adaptação gradual da actividade física ocorre em um contexto de elevada excreção de adrenalina (E), norepinefrina (NE), mas sem capacidades de reabastecimento suficientes Reserva SAS. o que é confirmado por alterações mínimas na excreção de dopamina (DA) e DOPA nestes grupos etários. Aos 14-16 anos, E e NE variações moderadas em resposta à actividade no contexto de um aumento significativo da excreção de precursores, o que caracteriza a resposta SAS para um teste funcional, mais economia, com o aumento observado a capacidade de reserva

A clinical case of a patient with probable cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) from Chuvashia

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) syndrome is a congenital small-vessel disease running with recurrent lacunar infarcts and leading to gradually progressive subcortical, pseudobulbar, and cerebellar syndromes and dementia. Neuroimaging reveal multiple lacunar infarcts in the basal ganglia, thalamus, pons Varolii, and cerebral hemispheric white matter, as well as cerebral atrophy. The specific feature of the disease is white matter lesion adjacent to the temporal horns of the lateral ventricles and to the external capsules. The paper describes a patient with CADASIL syndrome. The latter runs a progressive course and includes the following neurological disorders: cognitive, pyramidal, extrapyramidal, and axial ones. This clinical case was differentially diagnosed with multiple sclerosis, including with consideration for neuroimaging findings. The CADASIL syndrome is a rare potentially menacing neurological condition that is observed in young patients and requires a detailed examination using current diagnostic techniques

International Geomagnetic Reference Field: the 12th generation

The 12th generation of the International Geomagnetic Reference Field (IGRF) was adopted in December 2014 by the Working Group V-MOD appointed by the International Association of Geomagnetism and Aeronomy (IAGA). It updates the previous IGRF generation with a definitive main field model for epoch 2010.0, a main field model for epoch 2015.0, and a linear annual predictive secular variation model for 2015.0-2020.0. Here, we present the equations defining the IGRF model, provide the spherical harmonic coefficients, and provide maps of the magnetic declination, inclination, and total intensity for epoch 2015.0 and their predicted rates of change for 2015.0-2020.0. We also update the magnetic pole positions and discuss briefly the latest changes and possible future trends of the Earth’s magnetic fiel

Network analysis of human glaucomatous optic nerve head astrocytes

<p>Abstract</p> <p>Background</p> <p>Astrocyte activation is a characteristic response to injury in the central nervous system, and can be either neurotoxic or neuroprotective, while the regulation of both roles remains elusive.</p> <p>Methods</p> <p>To decipher the regulatory elements controlling astrocyte-mediated neurotoxicity in glaucoma, we conducted a systems-level functional analysis of gene expression, proteomic and genetic data associated with reactive optic nerve head astrocytes (ONHAs).</p> <p>Results</p> <p>Our reconstruction of the molecular interactions affected by glaucoma revealed multi-domain biological networks controlling activation of ONHAs at the level of intercellular stimuli, intracellular signaling and core effectors. The analysis revealed that synergistic action of the transcription factors AP-1, vitamin D receptor and Nuclear Factor-kappaB in cross-activation of multiple pathways, including inflammatory cytokines, complement, clusterin, ephrins, and multiple metabolic pathways. We found that the products of over two thirds of genes linked to glaucoma by genetic analysis can be functionally interconnected into one epistatic network via experimentally-validated interactions. Finally, we built and analyzed an integrative disease pathology network from a combined set of genes revealed in genetic studies, genes differentially expressed in glaucoma and closely connected genes/proteins in the interactome.</p> <p>Conclusion</p> <p>Our results suggest several key biological network modules that are involved in regulating neurotoxicity of reactive astrocytes in glaucoma, and comprise potential targets for cell-based therapy.</p

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Influences of Co-Content on the Physico-Chemical and Catalytic Properties of Perovskite GdCo_xFe_1−xO₃ in CO Hydrogenation

The effect of the substitution of cobalt into the GdFeO3 perovskite structure on the selective hydrogenation of CO was investigated. A series of GdCoxFe1−xO3 (x = 0; 0.2; 0.5; 0.8; 1) samples were synthesized by sol-gel technology and characterized by XRD, BET specific area, DSC, TG, EDX and XPS. The experimental data made it possible to reveal a correlation between the state of iron and cobalt atoms, the fractions of surface and lattice oxygen, and catalytic characteristics. It has been found that varying the composition of GdCoxFe1−xO3 complex oxides leads to a change in the oxygen-metal binding energy in Gd-O-Me, the ratio of metals in various oxidation states, and the amount of surface and lattice oxygen, which affects the adsorption and catalytic characteristics of complex oxides

Factors determining the readiness of a patient with coronary artery disease to use telemedicine technologies for rehabilitation: prospective cohort study

BACKGROUND: Despite its relevance and established efficiency, the third stage of cardiac rehabilitation (CR) lacks a universal solution. The longest rehabilitation period requires many resources and effort on the part of the healthcare system. Digital technologies rapidly developing and being introduced into medicine can significantly assist in organizing the CR process. The healthcare system is already mastered and actively adopting telemedicine technologies into daily practice. OBJECTIVE: We aimed to determine the patients’ preparedness for the upcoming surgical treatment of the chronic types of coronary artery disease to engage in remote cardiac rehabilitation programs using telemedicine technologies. MATERIALS AND METHODS: A study of 213 patients treated for artery disease and preparing for planned coronary bypass surgery was conducted. Gender, age, socioeconomic factors, and digital literacy were analyzed. The patients were offered one of two options for completing the third stage of CR: a standard option in which CR is performed under the supervision of a medical worker in a medical organization at the place of residence according to the recommendations received upon hospital discharge or an alternative in which CR is performed at home using remote monitoring under the supervision of specialists from the CR laboratory of the Research Institute for Complex Issues of Cardiovascular Diseases. Patients were divided into two groups based on their choice: those who agreed to participate in the outpatient stage of CR using telemedicine technologies (loyal patients) and those who refused to use telemedicine technologies (nonloyal patients). The factors indicating more loyalty were identified using survey data and correlation analysis, and a portrait of a patient eager to use remote rehabilitation programs was formed. RESULTS: Social factors, such as living in big cities (p 0.001) and having a spouse (p=0,030), were associated with increased loyalty to participating in CR via telemedicine technologies. Male gender (p 0.001), obesity (p 0.001), and smoking (p 0.001) were associated with the reluctance to participate in the alternative CR program. The education level (p=0.060) did not show a significant impact on the loyalty to use telemedicine technologies. CONCLUSION: 46% of patients were interested in using remotely controlled CR programs. The social factors determine the loyalty to telemedicine technologies in patients

Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis

Aim.  To compare HLA II allele and genotype frequency distribution in type 1 diabetes mellitus (T1DM) and autoimmune thyroiditis (AIT) with that in isolated T1DM. Materials and Methods. A total of 92 T1DM patients were subdivided into two groups. The first group comprised 54 patients with established AIT comorbidity or elevation of anti-thyroid autoantibodies (ATA). Patients with isolated T1DM (ATA-negative) formed the second group. HLA-genotyping was performed by multiprimer PCR set for the three following genes: DRB1, DQA1 and DQВ1. Results.  Prevalence of alleles DRB1*01, *03(017), *04, *07, *11 and genotypes 01/03, 01/04, 03/04 tends to be higher among patients with AIT comorbidity. The comorbidity group was also characterized by the trend towards higher prevalence of ?marker/marker? and ?marker/non-marker? combinations favouring the former variant. Conversely, ATA-negative patients exhibited trend for higher prevalence of ?non-marker/non-marker? combination. Conclusion. Statistically insignificant difference between HLA II alleles and genotypes in the two studied groups suggests that primary genetic factors are common in these two diseases. Plausibly, genes other than DRB1, DQA1 and DQВ1 determine the localization of the autoimmune process

Insights into the Reactivity of Gd_2−xSr_xFe₂O₇ (x = 0 ÷ 0.4) in CO Radical Hydrogenation

The effect of strontium substitution in the structure of the complex oxide Gd2SrFe2O7 on the production of light olefins by CO hydrogenation was investigated. Perovskite-type oxides Gd2−xSr1+xFe2O7 (x = 0; 0.1; 0.2; 0.3; 0.4) were synthesized by sol–gel technology and characterized by XRD, Mössbauer spectroscopy, BET specific area, acidity testing, and SEM. The experimental data revealed a correlation between the state of iron atoms, acidity, and catalytic performance. It was found that with an increase in the content of Sr2+ in the perovskite phase, the basicity of the surface and the oxygen diffusion rate increased. This contributed to the CO dissociative adsorption, formation of active carbon, and its further interaction with atomic hydrogen

Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers

Aim. To analyse association of class II HLA genotype (DRB1, DQA1, DQB1) with type 1 diabetes mellitus (DM1) in an Udmurtian population. Materials and methods. The case-control method was applied in the study involving 29 children with DM1 and 97 age-matched healthy subjects. HLAalleles were identified by multiprimer allele-specific PCR. Association with DM1 was evaluated from the OR-odds ratio. Calculations were made usingStatSoft and STATISTICA 6 programs. Results. The occurrence of ?classical? highly predisposing haplotypes in the studied Udmurtian population proved significantly lower than in otherCaucasoid populations (DRB1*04-DQA1*0301-DQB1*0302 - 2,6 vs 8-16% and DRB1*17(03)-DQA*0501-DQB1*0201 - 3,6 vs 6-12,9%)trans-Encoded DQ heterodimers (DQA1*0301-DQB1*0201 and DQA1*0301-DQB1*0302) were shown to play the key role in determining the riskof DM1. They were found in 62,1% of the patients compared with 10,3% of control subjects (OR=14,2; pc=6Ч10-5). Conclusion. Positive DQA1*0301-DQB1*0302 or/and *0201 genotype is the most sensitive predictor of DM1 in the studied Udmurtian population