875 research outputs found

    Differential impact of affective and cognitive attributes on preference under deliberation and distraction

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    Two experiments were designed to test the hypothesis that affective information looms relatively larger than cognitive information when individuals are distracted for a period of time compared to when they engage in deliberative thinking. In two studies, participants were presented with information about 4 decision alternatives: An affective alternative that scored high on affective attributes but low on cognitive attributes, a cognitive alternative with the opposite trade-off, and two fillers. They were then asked to indicate their attitudes toward each of four decision alternatives either immediately, after a period of deliberation, or after a period of distraction. The results of both experiments demonstrated that participants significantly preferred the affective alternative to the cognitive alternative after distraction, but not after deliberation. The implications for understanding when and how unconscious thought may lead to better decisions are being discussed

    Sky reconstruction for the Tianlai cylinder array

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    In this paper, we apply our sky map reconstruction method for transit type interferometers to the Tianlai cylinder array. The method is based on the spherical harmonic decomposition, and can be applied to cylindrical array as well as dish arrays and we can compute the instrument response, synthesised beam, transfer function and the noise power spectrum. We consider cylinder arrays with feed spacing larger than half wavelength, and as expected, we find that the arrays with regular spacing have grating lobes which produce spurious images in the reconstructed maps. We show that this problem can be overcome, using arrays with different feed spacing on each cylinder. We present the reconstructed maps, and study the performance in terms of noise power spectrum, transfer function and beams for both regular and irregular feed spacing configurations.Comment: 15 pages, 12 figures, accepted by RA

    Association between aspirin and mortality in critically ill patients with atrial fibrillation: a retrospective cohort study based on mimic-IV database

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    BackgroundAtrial fibrillation (AF) is a prevalent issue among critically ill patients, and the availability of effective treatment strategies for AF is limited.AimThe objective of this study was to evaluate the mortality rate associated with AF in critically ill patients who were either aspirin or non-aspirin users.MethodsThis cohort study incorporated critically ill patients with AF from the Medical Information Mart for Intensive Care database. The study compared incidences of 28-day mortality, 90-day mortality, and 1-year mortality between patients with and without aspirin prescriptions. To assess the association between aspirin and the endpoints, Kaplan-Meier analysis and Cox proportional hazards regression analyses were conducted.ResultsIn this study, a total of 13,330 critically ill patients with atrial fibrillation (AF) were included, of which 4,421 and 8,909 patients were categorized as aspirin and non-aspirin users, respectively. The 28-day, 90-day, and 1-year mortality rates were found to be 17.5% (2,330/13,330), 23.9% (3,180/13,330), and 32.9% (4,379/13,330), respectively. The results of a fully-adjusted Cox proportional hazard model indicated that aspirin use was negatively associated with the risk of death after adjusting for confounding factors (28-day mortality, HR 0.64, 95% CI 0.55–0.74; 90-day mortality, HR 0.65, 95% CI 0.58–0.74; 1-year mortality, HR 0.67, 95%CI 0.6∼0.74). The results of the subgroup analysis indicate a more robust correlation, specifically among patients under the age of 65 and those without a history of congestive heart failure or myocardial infarction.ConclusionsThe utilization of aspirin may exhibit a correlation with a reduction in risk-adjusted mortality from all causes in critically ill patients diagnosed with atrial fibrillation. However, additional randomized controlled trials are necessary to elucidate and confirm this potential association

    Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction.

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    Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis. However, whether increased Omi/HtrA2 within mitochondria itself influences myocardial survival in vivo is unknown. We aim to observe the effects of mitochondria-specific, not cytoplasmic, Omi/HtrA2 on myocardial apoptosis and cardiac function. Transgenic mice overexpressing cardiac-specific mitochondrial Omi/HtrA2 were generated and they had increased myocardial apoptosis, decreased systolic and diastolic function, and decreased left ventricular remodeling. Transiently or stably overexpression of mitochondria Omi/HtrA2 in H9C2 cells enhance apoptosis as evidenced by elevated caspase-3, -9 activity and TUNEL staining, which was completely blocked by Ucf-101, a specific Omi/HtrA2 inhibitor. Mechanistic studies revealed mitochondrial Omi/HtrA2 overexpression degraded the mitochondrial anti-apoptotic protein HAX-1, an effect attenuated by Ucf-101. Additionally, transfected cells overexpressing mitochondrial Omi/HtrA2 were more sensitive to hypoxia and reoxygenation (H/R) induced apoptosis. Cyclosporine A (CsA), a mitochondrial permeability transition inhibitor, blocked translocation of Omi/HtrA2 from mitochondrial to cytoplasm, and protected transfected cells incompletely against H/R-induced caspase-3 activation. We report in vitro and in vivo overexpression of mitochondrial Omi/HtrA2 induces cardiac apoptosis and dysfunction. Thus, strategies to directly inhibit Omi/HtrA2 or its cytosolic translocation from mitochondria may protect against heart injury

    Evoke: Evoking Critical Thinking Abilities in LLMs via Reviewer-Author Prompt Editing

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    Large language models (LLMs) have made impressive progress in natural language processing. These models rely on proper human instructions (or prompts) to generate suitable responses. However, the potential of LLMs are not fully harnessed by commonly-used prompting methods: many human-in-the-loop algorithms employ ad-hoc procedures for prompt selection; while auto prompt generation approaches are essentially searching all possible prompts randomly and inefficiently. We propose Evoke, an automatic prompt refinement framework. In Evoke, there are two instances of a same LLM: one as a reviewer (LLM-Reviewer), it scores the current prompt; the other as an author (LLM-Author), it edits the prompt by considering the edit history and the reviewer's feedback. Such an author-reviewer feedback loop ensures that the prompt is refined in each iteration. We further aggregate a data selection approach to Evoke, where only the hard samples are exposed to the LLM. The hard samples are more important because the LLM can develop deeper understanding of the tasks out of them, while the model may already know how to solve the easier cases. Experimental results show that Evoke significantly outperforms existing methods. For instance, in the challenging task of logical fallacy detection, Evoke scores above 80, while all other baseline methods struggle to reach 20

    Summary and application analysis of clinical herniorrhaphy mesh materials

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    It is widely believed in the medical community that the pathological and anatomical basis for the occurrence of external abdominal hernia is the fascia defect, and how to correctly deal with this kind of fascia defect is the key point in the treatment of external abdominal hernia. Theodore Billorth famously said that if we could artificially create dense and tough tissues like fascia and tendons, the secret to the complete healing of hernia would be solved. These similar theories largely guide the research and practice in the treatment of external abdominal hernia. along with the breakthrough progress in the mesh treatment of external abdominal hernia, According to the chemical composition and biological characteristics, the patch materials can be divided into non-absorbable materials, absorbable materials, composite repair materials and biological materials. Methods In this paper, Pubmed database and Chinese journal full-text database literatures were searched,and all mesh materials used in inguinal hernia repair were comprehensively studied, summarized and analyzed in clinical application. Keywords: external abdominal hernia; patch material; conclusion; applicatio
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