Chitetezo Cooperative Federation: Capacity building report January to June 2023

The objective of this report is to highlight the capacity-building activities conducted by the Community Market for Conservation (COMACO) through the Chitetezo Cooperative Federation (CCF) in collaboration with the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT). Capacity building activities focused on the following trainings: (i) Crop market workshops with stakeholders; (ii) Cashier or literacy trainings; (iii) chiefdom or cooperative Training on Crop markets; (iv) Field day activities; and (iv) Agroforestry trainings

Impact of CSA technology packages on smallholder farmers under the accelerator program in Zambia

The primary goal of this report is to provide evidence on the impact of CSA technology packages on smallholder farmers under the accelerator programme in in Zambia. The AICCRA Zambia accelerator program tested various CSA technology packages, designed and implemented through agribusiness partnerships, SME bundles. The SME bundles were selected through a competitive process for the packages to address major challenges for CSA in Zambia and covering major agricultural production systems in Zambia. Each bundle was supported by a 50,000-USD grant

ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.

Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans, an understudied ancestral group. We analyze ~18 million autosomal SNPs in 5,231 individuals from Nigeria, Ghana and Kenya. We identify a previously-unreported genome-wide significant locus: ZRANB3 (Zinc Finger RANBP2-Type Containing 3, lead SNP p = 2.831 × 10-9). Knockdown or genomic knockout of the zebrafish ortholog results in reduction in pancreatic β-cell number which we demonstrate to be due to increased apoptosis in islets. siRNA transfection of murine Zranb3 in MIN6 β-cells results in impaired insulin secretion in response to high glucose, implicating Zranb3 in β-cell functional response to high glucose conditions. We also show transferability in our study of 32 established T2D loci. Our findings advance understanding of the genetics of T2D in non-European ancestry populations

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Chitetezo Cooperative Federation Proof of Concept: Legume Value Chains, Changing Lives, Protecting Nature

Community Markets for Conservation (COMACO) is a social enterprise with a mission to work with communities to secure a better life and become good stewards of their natural resources. COMACO finances enhanced climate-smart agricultural practises through the adoption of a legume-based farming system and agroforestry that increase crop yields. It also provides market opportunities for smallholder farmers by selling a variety of nature-based food products through a country-wide retail brand, "It’s Wild", and linking to carbon markets with positive conservation outcomes, including more trees, more wildlife, and healthier soils. COMACO is working with 230,000 registered farmers. Of these, 137,153 (56% women) have so far planted Gliricidia seedlings in their fields. Together, the farmers have planted a total of 37.1 million seedlings, covering 16,200 hectares of land affected by climate change

Factors Affecting Sugarcane Production by Small-Scale Growers in Ndwedwe Local Unicipality, South Africa

Sugarcane is an important crop worldwide due to its many nutritional and economic uses. Small-scale sugarcane growers (SSGs) are a significant sector of sugarcane production in South Africa. However, the number of SSGs is noted to have declined from as early as the 2000s to the present time. As a result of the declining sugarcane production, there are now generally fewer SSGs. However, it is not clear cut as to what caused the decrease in sugarcane production by SSGs. The primary objective of this paper is to determine the factors affecting the sugarcane production by SSGs in Mona and Sonkombo in Ndwedwe Local Municipality. Data collection was through a well-structured questionnaire administered to 100 SSGs (that is, 50 respondents each from the study sites, namely Mona and Sonkombo) that were randomly selected. The paper employs descriptive statistics to describe farm characteristics, and a production function (Cobb–Douglass production function (CDPF)) analysis using the ordinary least squares (OLS) criterion to estimate the parameters affecting sugarcane production. Results show that late harvesting (by up to three (3) weeks), late fertiliser application (by up to six (6) months, and chemicals (Gramoxone) application (by up to five (5) months) were primary challenges facing SSGs, likely to result in declining sugarcane yield. The CDPF regression analysis reveals that significant predictors of the production function are: labour and the amount of chemicals (Gramoxone) applied. Labour (man-days/ha), amount of chemicals (Gramoxone) applied are found to be statistically significant and positively correlated with sugarcane production. The government, through the relevant Department of Agriculture, including the private sector, should intensify out-grower technical services for SSGs to realise higher production per hectare. Such services would ensure optimal allocation and application of inputs, labour and chemicals (herbicides and pesticides), respectively, at the right time to ensure efficacy. There is also a need to introduce buying consortiums for SSGs to reduce the costs of inputs