A critical analysis of COA research.

Five experts respected for their significant contributions to the scientific literature on children of alcoholics (COA's) offer their perspectives in a panel discussion format. The panel members reflect on the historical roots of COA research and comment on its current status and future direction. Enriched by the panelists' variety of backgrounds, research interests, and approaches, the discussion emphasizes the need to consider multiple variables that influence the risk for alcoholism among COA's

Idiopathic Bilateral Internal Jugular Vein Thrombosis Diagnosed by Point-of-Care Ultrasound

Internal jugular vein (IJV) thrombosis is an unusual condition, especially when it develops bilaterally. This is a case of bilateral IJV thrombosis in a 77-year old female who presented to the emergency department with neck and arm swelling after discontinuing apixaban and undergoing an oropharyngeal procedure. The diagnosis of bilateral IJV thrombosis was made with the use of point-of-care ultrasound to evaluate bilateral jugular vein distention and bilateral upper extremity pitting edema found on her physical examination

The analysis of ion flow between the human body and local ground

The project was designed to get a better sense of the phenomenon referred to as Earthing. Earthing is defined as the process where the human body is in contact with the earth and can freely transfer ions between the Earth and itself. Those promoting the idea of earthing say that this transfer of ions is important in maintaining a healthy immune system, and they claim that the recent increase in autoimmune diseases is the result of humans being insulated from the ground because of the shoes they wear and the places in which they live

A low-mass stellar companion of the planet host star HD75289

We report on the detection of a new low-mass stellar companion of HD75289, a G0V star that harbors one known radial-velocity planet (Udry et al. 2000). Comparing an image of 2MASS with an image we obtained with SofI at the ESO 3.58m NTT three years later, we detected a co-moving companion located 21.465+-0.023arcsecs (621+-10AU at 29pc) east of HD75289. A second SofI image taken 10 months later confirmed the common proper motion of HD75289B with its host star. The infrared spectrum and colors of the companion are consistent with an M2 to M5 main-sequence star at the distance of HD75289. No further (sub)stellar companion down to H = 19mag could be detected. With the SofI detection limit we can rule out additional stellar companions beyond 140AU and substellar companions with masses m > 0.050Msun from 400AU up to 2000AU.Comment: accepted in A&

Nebivolol, a beta adrenergic receptor antagonist blocks angiotensin II-mediated signaling in heart [abstract]

We recently showed that Nebivolol, a [beta]-adrenergic receptor (AR) antagonist attenuates myocardial oxidative stress and promotes insulin metabolic signaling in 9 week old Zucker obese (ZO) insulin resistant rats. Here, we demonstrate that Nebivolol suppresses angiotensin II type I receptor (AT1R)-mediated signaling in ZO hearts as well as in HL-1 cardiomyocytes

Paul Zucker and the rhythm of space, analysis of an aesthetic theory of architecture that correlates function, time and space

Paul Zucker, "who loved beauty in all its forms and who understood how to bring this love to others."1 jt, I theories of the German architect and art historian Paul Zucker (1888-19712). Vi * I I>ilLll /-t-ieker studied ureliiteeturo and art history in Berlin and Munich. In the early 20th century he worked and lived in Berlin as professional architect and art historian, university lecturer at Lessing- H Hochschule, editor, author and architectural critic. 'B Until the 1930s Zucker enjoyed a high reputation in Berlin's intellectual circles. He published many 2 Knowledgeable and cultivated... books, reviews and articles and designed several Zucker in his library, New York, 1968 stores, town and country' houses in and around Berlin. His established livelihood came to an end though with the onset of the Nazi- Regime when he was forced to flee Germany during the Jewish Persecution. Paul Zucker emigrated to New York City in 1937 and after some initial difficulties was able to start a new life, becoming lecturer at Cooper Union Art School and the New School of Social Research in New York. Though unfortunately not able to work again as professional architect. Zucker published and lectured in New York until his death in 1971

Quantifying the impacts of regulatory delay on housing affordability and quality in Austin, Texas

textRegulatory delay during site plan review of multifamily projects in Austin has three primary impacts: 1) it generates unexpected development costs which increases housing prices over-time; 2) it stifles innovation and decreases quality of development; and 3) it promotes exurban growth. These impacts reduce affordability and quality of life for all Austinites and thwart the goals of the Imagine Austin comprehensive plan. As regulatory delays have increased remarkably since 2009, strong rent growth has compensated for this growing uncertainty throughout the Austin market. If regulatory delays are eliminated and developers receive approvals for multifamily projects within the 120 day mandate instead of the 223 day average, renters could see relief of 4-5% on their rent, or an average of $60 per month or$720 annually in Central Austin. Interviews with 14 Austin-area residential developers confirm these delays, costs, and impacts on their projects. On average it takes 3.5 additional months to receive site plan approvals in Austin in addition to the code mandated four month cycle. Austin's peer cities fare differently. The average delay in Denver, Colorado is three weeks, and is just several days in Raleigh, North Carolina. Whereas land use regulations theoretically generate positive externalities, delays in administering those regulations generate no benefits to the community. During this unforeseen 3.5 months, developers accrue unexpected costs such as legal fees, and developer overhead which includes the opportunity costs of not pursuing other deals. Construction costs increase during delays, and developers must continue to pay for land options and carry costs. In the short-term, developers pay for these unexpected costs out-of-pocket, and by reducing construction costs, which can result in lower quality materials or amenities. Unexpected costs roll into the project's overall budget, resulting in more expensive development projects. More expensive projects require higher rents in order to maintain the development team's expected yield on cost. Further, interviews with urban designers and civil engineers reveal that regulatory delay stifles private sector innovation in the built environment. Developer interviews and case studies suggest that regulatory delay promotes exurban growth instead of urban infill in the Austin metropolitan area.Community and Regional Plannin