La sobrecarga de información percibida por los estudiantes universitarios y su influencia en el síndrome de respuesta inmediata al smartphone durante la pandemia de la COVID-19: Tomando la perspectiva de la personalidad

The COVID-19 pandemic has affected university students’ learning and social interaction to a large level, causing different degrees of negative emotions and made them extremely sensitive to smartphone information. However, little is known about the link between personalities, perceived information overload (PIO) and smartphone immediate response syndrome (SIRS) during students' learning process in this specific emergency social context. Therefore, based on the person-environment fit model, this study investigated 482 university students from mainland China during the epidemic by a snowball sampling approach, and analyzed the relationship between their personalities, PIO and SIRS by structural equation modeling. Results indicated that individuals with extraversion and neuroticism formed SIRS from different psychological paths. PIO plays a partial mediating role between neuroticism and SIRS and a fully mediating role between extraversion and SIRS. These findings validate the association among individual personality, PIO and SIRS in the non-conventional environment and highlights the difference exist in cellphone-related psychological path between extraverted and neurotic students. Therefore, it is recommended that PIO should be controlled in a targeted manner for individuals with different personality and guide them using cellphones rationally during the epidemic.La pandemia causada por la COVID-19 ha afectado en gran medida al aprendizaje y a la interacción social de los estudiantes universitarios, provocando emociones negativas de diferentes grados y haciéndoles extremadamente sensibles a la información de los smartphones. Sin embargo, se sabe poco sobre la relación entre la personalidad, la sobrecarga de información percibida (SIP) y el síndrome de respuesta inmediata al smartphone (SIRS) durante el proceso de aprendizaje de los estudiantes en este contexto social de emergencia específico. Por lo tanto, basándose en el modelo de ajuste persona-ambiente, este estudio investigó a 482 estudiantes universitarios de China continental durante la epidemia mediante un enfoque de muestreo de bola de nieve, y analizó la relación entre su personalidad, SIP y SIRS mediante un modelo de ecuaciones estructurales. Los resultados indicaron que los individuos con extraversión y neuroticismo formaron el SIRS a partir de diferentes vías psicológicas. La SIP desempeña un papel mediador parcial entre el neuroticismo y el SIRS y un papel totalmente mediador entre la extraversión y el SIRS. Estos resultados validan la asociación entre la personalidad individual, la SIP y el SIRS en el entorno no convencional y pone de manifiesto la diferencia que existe en la trayectoria psicológica relacionada con el teléfono móvil entre los estudiantes extrovertidos y los neuróticos. Por lo tanto, se recomienda controlar la SIP de forma específica para los individuos con personalidad diferente y guiarlos en el uso racional de los teléfonos móviles durante la epidemia

University students' perceived information overload mediates smartphone immediate response syndrome during COVID-19 outbreak: Taking the perspective of personality

The COVID-19 pandemic has affected university students’ learning and social interaction to a large level, causing different degrees of negative emotions and made them extremely sensitive to smartphone information. However, little is known about the link between personalities, perceived information overload (PIO) and smartphone immediate response syndrome (SIRS) during students' learning process in this specific emergency social context. Therefore, based on the person-environment fit model, this study investigated 482 university students from mainland China during the epidemic by a snowball sampling approach, and analyzed the relationship between their personalities, PIO and SIRS by structural equation modeling. Results indicated that individuals with extraversion and neuroticism formed SIRS from different psychological paths. PIO plays a partial mediating role between neuroticism and SIRS and a fully mediating role between extraversion and SIRS. These findings validate the association among individual personality, PIO and SIRS in the non-conventional environment and highlights the difference exist in cellphone-related psychological path between extraverted and neurotic students. Therefore, it is recommended that PIO should be controlled in a targeted manner for individuals with different personality and guide them using cellphones rationally during the epidemic

Cell transcriptomic atlas of the non-human primate Macaca fascicularis.

Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell-cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.We thank W. Liu and L. Xu from the Huazhen Laboratory Animal Breeding Centre for helping in the collection of monkey tissues, D. Zhu and H. Li from the Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) for technical help, G. Guo and H. Sun from Zhejiang University for providing HCL and MCA gene expression data matrices, G. Dong and C. Liu from BGI Research, and X. Zhang, P. Li and C. Qi from the Guangzhou Institutes of Biomedicine and Health for experimental advice or providing reagents. This work was supported by the Shenzhen Basic Research Project for Excellent Young Scholars (RCYX20200714114644191), Shenzhen Key Laboratory of Single-Cell Omics (ZDSYS20190902093613831), Shenzhen Bay Laboratory (SZBL2019062801012) and Guangdong Provincial Key Laboratory of Genome Read and Write (2017B030301011). In addition, L.L. was supported by the National Natural Science Foundation of China (31900466), Y. Hou was supported by the Natural Science Foundation of Guangdong Province (2018A030313379) and M.A.E. was supported by a Changbai Mountain Scholar award (419020201252), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030502), a Chinese Academy of Sciences–Japan Society for the Promotion of Science joint research project (GJHZ2093), the National Natural Science Foundation of China (92068106, U20A2015) and the Guangdong Basic and Applied Basic Research Foundation (2021B1515120075). M.L. was supported by the National Key Research and Development Program of China (2021YFC2600200).S

(S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1

Abstract Background Non–small cell lung cancer (NSCLC) accounts for approximately 80–85% of all lung cancers and is usually diagnosed at an advanced stage with poor prognosis. Targeted therapy has produced unprecedented outcomes in patients with NSCLC as a number of oncogenic drivers have been found. Crizotinib, a selective small-molecule inhibitor, has been widely used for the treatment of NSCLC patients with ALK gene rearrangements. A recent study has also shown that (S)-enantiomer of crizotinib exhibits anticancer activity by targeting the protein mutT homologue (MTH1). Since this discovery, contradictory studies have cast a doubt on MTH1 as a therapeutic target of (S)-crizotinib. Methods NCI-H460, H1975, and A549 cells and immunodeficient mice were chosen as a model to study the (S)-crizotinib treatment. The changes induced by (S)-crizotinib treatment in cell viability, apoptosis as well as ROS, and endoplasmic reticulum stress pathway in the cells were analyzed by MTT assay, FACSCalibur, Western blotting, ROS imaging and electron microscopy. Results Here, we report that MTH1 does not affect survival of NSCLC cells. We found that (S)-crizotinib induces lethal endoplasmic reticulum stress (ER) response in cultured NSCLC cells by increasing intracellular levels of reactive oxygen species (ROS). Blockage of ROS production markedly reversed (S)-crizotinib-induced ER stress and cell apoptosis, independent of MTH1. We confirmed these findings in NSCLC xenograft studies and showed that (S)-crizotinib-induced ER stress and cell apoptosis. Conclusions Our results reveal a novel antitumor mechanism of (S)-crizotinib in NSCLC which involves activation of ROS-dependent ER stress apoptotic pathway and is independent of MTH1 inhibition

Additional file 1: Figure S1. of (S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1

(S)-crizotinib induced cytotoxicity in NSCLC cells. Figure S2. Effect of SOD on (S)-crizotinib-induced apoptosis in NSCLC cells. (DOC 548 kb