Imputing missing data using grey system theory and the biplot method to forecast groundwater levels and yields

Groundwater management is one of today’s important tasks. It has become necessary to seek out increasingly reliable methods to conserve groundwater resources. Dependable forecasting of the amounts of groundwater that can be abstracted in a sustainable manner requires longterm monitoring of the groundwater regime (rate of abstraction and groundwater levels). Monitoring of the groundwater source for the town of Bečej, Serbia had been disrupted for multiple years. The objective of the paper is to assess the possibility of reinterpreting the missing data or, in other words, to reconstruct the operation of the groundwater source and its effect on groundwater levels. At the Bečej source, groundwater is withdrawn from three water-bearing strata comprised of fine- to coarse-grained sands. Historic data are used to reconstruct the operation of the Bečej source between 1st of October 1980 to 1st of May 2010. The monitored parameters are total source yield and piezometric head at seven observation wells and 14 pumping wells. A data reconstruction methodology was developed, which included the use of an autoregressive (AR) model, a grey model (GM), and the biplot method. The methodology is applied to fill the data gaps during the considered period. The paper also describes the criteria for evaluating the accuracy of the AR model, GM, and biplot method. The proposed data reconstruction approach yielded satisfactory results and the methodology is deemed useful for the Bečej source data, as well as other historic data not necessarily associated with groundwater sources, but also groundwater control and protection systems, as well as hydrometeorological, hydrological and similar uses

Civilian Casualty of Landmine – The Pattern of Injury and Course of Treatment

In Croatia civilian casualties of landmine explosions 20 years after the war are still present. The presented case is a 42 years old housewife who sustained multiple body and face injuries while cleaning her courtyard. The treatment was performed in several steps. Initial treatment included thoracic drainage, abdominal surgery and the rigid fixation of the mandibular defect. Four months later mandibular reconstruction with free flap was performed. After plate removal the restoration of dental status was performed by partial denture although the application of dental implants would be superior. The optimal rehabilitation was omitted because heath insurance policy does not provide the reimbursement of dental implants costs for outpatients even in cases of landmine victims traumatic teeth loss

Civilian Casualty of Landmine – The Pattern of Injury and Course of Treatment

In Croatia civilian casualties of landmine explosions 20 years after the war are still present. The presented case is a 42 years old housewife who sustained multiple body and face injuries while cleaning her courtyard. The treatment was performed in several steps. Initial treatment included thoracic drainage, abdominal surgery and the rigid fixation of the mandibular defect. Four months later mandibular reconstruction with free flap was performed. After plate removal the restoration of dental status was performed by partial denture although the application of dental implants would be superior. The optimal rehabilitation was omitted because heath insurance policy does not provide the reimbursement of dental implants costs for outpatients even in cases of landmine victims traumatic teeth loss

Theoretical support of modern issues related to laser techniques, applications of coherent radiation and modern technologies

Modern problems of the Earth’s population are increasing in the areas related to the basic concepts of survival of living beings, but also with opposite views, if parallels are made between energy and ecology. Many new technologies are searching for their way towards development and must be viewed from several points of view. Inthis paper, the issue is addressed through modern laser techniques in terms of obtaining energy for various purposes concerning selected roles in medicine, as well as the impact on flora, fauna and as a support to other technologies both classical and modern. Contemporary attributes of lasers and other quantum generators in termsof coherence, power and intensity densities have significantly increased, although some predictions from the time of the first quantum generator masers, like gammarasers (and X raser) are still relatively far from commercial concepts. Some of the possible contemporary implementations of quantum generators in measurements control and processing schemes, along with other possible applications of various laser types, have been estimated. The paper focuses on the characterization of today’s problems with Covid-19 virus, only from the engineering point of view. The lexical side of the issue is also included, as well as the social management needswith the application of modern technologies, including help from natural sciences

Supporting information for: Water-Tuned Tautomer-Selective Tandem Synthesis of the 5,6-Dihydropyrimidin-4(3 H )-ones, Driven under the Umbrella of Sustainable Chemistry

The selective synthesis of 5,6-dihydropyrimidin-4(3H)-one scaffold (precursor of dihydrouracil) was a very difficult synthetic challenge that, so far, has not been achieved. For the first time, in this paper, green, selective and high-yields approach to 40 novel 5,6-dihydropyrimidin-4(3H)-ones (DHPMs) by one-pot reaction of aldehydes, Meldrum's acid and isothioureas under solvent-free conditions, in the presence of water, since an additive is presented. In the majority of cases, introduced methodology gave an unprecedented tautomer-selective fashion toward targeted compounds with excellent tautomeric purity (>99.9%), which reached 100% in few cases. The molecular structure of the five compounds has been determined by X-ray crystallography. In each one of them, very short length for the corresponding N2-C1 bond was noticed, making them especially interesting from a structural standpoint. This experimental fact can imply a highly localized electron π density in this part of each heterocyclic ring. The obtained experimental results, which are determined from NMR and ESI-MS study, indicate that this Biginelli-type reaction smoothly proceeds in a one-pot mode, pointing to the three-step tandem process, proceeding via the Knoevenagel, aza-Michael, and retro-Diels-Alder reactions. The presented strategy also had the following advantages: reduction amount of waste, excellent values of green chemistry metrics (cEF, EcoScale and GCIS), and it is the first eco-friendly strategy toward the DHPMs scaffold. © Copyright 2018 American Chemical Society.Supplementary data for the article: [https://dx.doi.org/10.1021/acssuschemeng.8b03127]Related to: [http://vinar.vin.bg.ac.rs/handle/123456789/7886

Docking studies, cytotoxicity evaluation and interactions of binuclear copper(ii) complexes with s-isoalkyl derivatives of thiosalicylic acid with some relevant biomolecules

The numerous side effects of platinum based chemotherapy has led to the design of new therapeutics with platinum replaced by another transition metal. Here, we investigated the interactions of previously reported copper(II) complexes containing S-isoalkyl derivatives, the salicylic acid with guanosine-5′-monophosphate and calf thymus DNA (CT-DNA) and their antitumor effects, in a colon carcinoma model. All three copper(II) complexes exhibited an affinity for binding to CT-DNA, but there was no indication of intercalation or the displacement of ethidium bromide. Molecular docking studies revealed a significant affinity of the complexes for binding to the minor groove of B-form DNA, which coincided with DNA elongation, and a higher affinity for binding to Z-form DNA, supporting the hypothesis that the complex binding to CT-DNA induces a local transition from B-form to Z-form DNA. These complexes show a moderate, but selective cytotoxic effect toward colon cancer cells in vitro. Binuclear complex of copper(II) with S-isoamyl derivative of thiosalicylic acid showed the highest cytotoxic effect, arrested tumor cells in the G2/M phase of the cell cycle, and significantly reduced the expression of inflammatory molecules pro-IL-1β, TNF-α, ICAM-1, and VCAM-1 in the tissue of primary heterotopic murine colon cancer, which was accompanied by a significantly reduced tumor growth and metastases in the lung and liver

Dehydrozingerone analogues: Reaction of O-alkyl derivatives of vanillin and methyl cyclopropyl ketone

O-Alkyl vanillines and methyl cyclopropyl ketone reacts under Claisen- Schmidt conditions yielding corresponding enone derivatives, dehydrozingerone analogues with cyclopropane ring fragment, (E)-1-cyclopropyl-3-(4-alkoxy-3- methoxyphenyl)prop-2-en-1-ones. All new compounds were well characterized by IR, 1H and 13C NMR spectroscopy and physical data