Exploring the role of immune pathways in the risk and development of depression in adolescence : research protocol of the IDEA-FLAME study

Extensive research suggests a role for the innate immune system in the pathogenesis of depression, but most of the studies are conducted in adult populations, in high-income countries and mainly focus on the study of inflammatory proteins alone, which provides only a limited understanding of the immune pathways involved in the development of depression. The IDEA-FLAME study aims to identify immune phenotypes underlying increased risk of developing depression in adolescence in a middle-income country. To this end, we will perform deep-immunophenotyping of peripheral blood mononuclear cells and RNA genome-wide gene expression analyses in a longitudinal cohort of Brazilian adolescents stratified for depression risk. The project will involve the 3-year follow-up of an already recruited cohort of 150 Brazilian adolescents selected for risk/presence of depression on the basis of a composite risk score we developed using sociodemographic characteristics (50 adolescents with low-risk and 50 with high-risk of developing depression, and 50 adolescents with a current major depressive disorder). We will 1) test whether the risk group classification at baseline is associated with differences in immune cell frequency, phenotype and functional status, 2) test whether baseline immune markers (cytokines and immune cell markers) are associated with severity of depression at 3-year follow-up, and 3) identify changes in gene expression of immune pathways over the 3-year follow-up in adolescents with increased risk and presence of depression. Because of the exploratory nature of the study, the findings would need to be replicated in a separate and larger sample. Ultimately, this research will contribute to elucidating key immune therapeutic targets and inform the development of interventions to prevent onset of depression among adolescents

CSL ACA Matrix Tuning Report

This document has been issued in the frame of ASI contract that has been released for the activities of Planck-LFI Phase E2 This document is a report of the LFI LNAs Tuning Verification performed at Centre Spatiale de Liege during the TV / TB campaign. In particular the test phases are from Ph–5–03 to Ph-5-04-d-1

In-flight calibration and verification of the Planck-LFI instrument

In this paper we discuss the Planck-LFI in-flight calibration campaign. After a brief overview of the ground test campaigns, we describe in detail the calibration and performance verification (CPV) phase, carried out in space during and just after the cool-down of LFI. We discuss in detail the functionality verification, the tuning of the front-end and warm electronics, the preliminary performance assessment and the thermal susceptibility tests. The logic, sequence, goals and results of the in-flight tests are discussed. All the calibration activities were successfully carried out and the instrument response was comparable to the one observed on ground. For some channels the in-flight tuning activity allowed us to improve significantly the noise performance.Comment: Long technical paper on Planck LFI in flight calibration campaign: 109 pages in this (not final) version, 100 page in the final JINST versio

Quick Look Data Analysis of LFI from CRYO-02 functional test

This document ha sbeen issued in the frame of ASI contract that has been released for the activities of Planck-LFI Phase E2 Scope of this document is to give a first quick look analysis response of the functionality of the LFI instrument during its first Functional cryogenic Test in nominal conditions (CRYO 02) performed in CSL- Liegi on July 2008 the 6th

Planck-LFI CPV: 1 Hz frequency spikes

Planck LFI Commissioning and Performance Verification (CPV)Spurious frequency spikes at the fundamental frequency of 1 Hz are known to be present in the LFI scientific data caused by an anomalous interaction between the DAE housekeeping sequencer and the scientific channels. The effect is a spurious signal that adds to the radiometric output after detection and is characterized by frequency spikes at the fundamental frequency of 1 Hz. These spikes are characterized by a series of tests run during all the test campaign in order to check this effect in different situations. Tests performed on ground at satellite level have shown that the effect of these spikes on the LFI science is expected to be very small; therefore the main objectives of the same tests performed during CPV is to compare results with those obtained during the CSL test campaign

Planck-LFI In-Orbit Calibration and Verification Phase Report: Executive Summary

Planck LFI Commissioning and Performance Verification (CPV)This document summarises the results obtained during the commissioning tests performed on the LFI integrated on the Planck satellite. Tests have been conducted from June the 4th 2009 to June 26th 2009. Details of the performed activities are discussed in specific reports that will be available after the CPV