Desmoplastic Fibroblastoma in Maxillary Alveolar Bone Mimicking An Odontogenic Lesion: A Novel Case Report with Review of Literature

Desmoplastic fibroblastoma (Collagenous fibroma) is a rare benign soft tissue tumor that disseminates widely and can be intramuscular or subcutaneously. There are seven reported cases in the oral cavity so far. We reported a novel case of collagenous fibroma that has been found in the anterior part of maxilla in a 58-year-old woman as an intraosseous radiolucent lesion that has been discovered during routine radiography. Histopathologically, spindle and stellate-shaped fibroblasts in a collagen-rich stroma as well as binucleated and multinucleated fibroblasts with prominent nucleoli were seen. Desmoplastic fibroblastoma could be found in jaw bones and excision of the lesion is curative, and no aggressive growth has been reported

Effect of home-used water purifier on fluoride concentration of drinking water in southern Iran

Background: Fluoride in drinking water plays a key role in dental health. Due to the increasing use of water-purifier, the effect of these devices on fluoride concentration of drinking water was evaluated. Materials and Methods: Drinking water samples were collected before and after passing through a home water-purifier, from four different water sources. The fluoride, calcium and magnesium concentration of the samples were measured using the quantitative spectrophotometery technique. Data were analyzed by the Wilcoxon test. P value < 0.1 was considered as significant. Results: The result showed that the concentration of fluoride was 0.05-0.61 ppm before purification and was removed completely afterward. Furthermore, other ions reduced significantly after treatment by the water purifier. Conclusion: This study revealed that this device decreases the fluoride content of water, an issue which should be considered in low and high-fluoridated water sources

CDC7 Expression in Selected Odontogenic Tumors

Objectives. CDC7 is a serine-threonine kinase that plays a key role in initiating DNA replication. It has been implicated in the growth and invasion of many pathologic lesions and suggested as a diagnostic marker. The aim of this study was to evaluate CDC7 in some odontogenic tumors. Materials and Methods. In this cross-sectional study, 45 cases, including 19 ameloblastomas, 15 dentigerous cysts, 7 ameloblastic fibromas, and 4 adenomatoid odontogenic tumors (AOT), were studied immunohistochemically. ANOVA and post hoc methods were used for statistical analysis. Results. CDC7 expression was observed in 93% of tumors and all dentigerous cysts. The expression rate was low. The results showed a higher expression rate of CDC7 in ameloblastoma and ameloblastic fibroma compared to AOT (p=0.009 and p=0.048, respectively). Ameloblastoma and ameloblastic fibroma were not significantly different in CDC7 expression (p=0.6). Conclusion. According to the results, the expression of the CDC7 protein in odontogenic tumors is low. The higher expression of CDC7 in ameloblastoma and ameloblastic fibroma in comparison with AOT confirms the hamartomatous growth of the latter, so it can be considered as a potential diagnostic marker. Future studies with a larger sample size are suggested to obtain a cut-off point for diagnostic purposes

A Clinico-Pathologic Study of 142 Orofacial Tumors in Children and Adolescents in Southern Iran

Objective: The prevalence, patients' age and sex and the site of the lesions are important factors for diagnosis and they may be different in various populations. The aim of this study was to determine the type and distribution of orofacial tumors among children and adolescents in an Iranian population Methods: In this retrospective, case series study, data about the type, age, sex and site of 142 tumors in patients =18 years afflicted with orofacial neoplasms referred 2005-2009 to two referral centers in Shiraz, Southern Iran, were collected and analyzed. Findings: There were 142 (2.8%) tumors among the subjects. The most common types of benign and malignant tumors were odontoma and lymphoma in children and pleomorphic adenoma and rhabdomyosarcoma in adolescents. Parotid and posterior parts of the mandible were the most common sites of soft tissue and intrabony tumors. In the oral cavity, the palate was the most common affected site. The tumors were found in boys with higher frequency (Male:Female ratio was 1.4:1). Conclusion: The observed differences in tumor type and distribution in comparison with previous studies may be attributed to genetic and geographic variations in the populations; however the design and methods of the studies are different, too

CD56 Expression in Odontogenic Cysts and Tumors

Background and aims. Odontogenic cysts and tumors have a wide spectrum of clinical characteristics that lead to the different management strategies. Since definite diagnosis is difficult in some cases, it has been suggested that CD56 may be a candidate marker for definitive diagnosis of some odontogenic tumors. The present study was designed to examine CD56 expression in lesions with histopathological similarities. Materials and methods. In this cross-sectional, analytical study the subjects were 22 ameloblastomas, 13 dentigerous cysts, 10 keratocystic odontogenic tumors (KCOT), 4 adenomatoid odontogenic tumors (AOT), 3 orthokeratinized odontogenic cysts, 3 calcifying odontogenic cysts (COC) and one glandular odontogenic cyst (GOC). All the samples were examined for CD56 immunoreactivity. Data were analyzed using chi-square test. Results. Twenty cases (91%) of ameloblastomas, 3 (75%) AOT, 4 (40%) KCOT and one case of GOC were positive for CD56. None of the dentigerous cysts, COC and orthokeratinized odontogenic cysts was CD56-positive. There was a significant difference in the CD56 expression between ameloblastoma and dentigerous cyst, as well as COC. Also, KCOT showed significantly higher expression than orthokeratinized odontogenic cyst. Conclusion. In this study CD56 expression was limited to the odontogenic tumors and more aggressive cystic lesions. This marker can be a useful aid for distinguishing cysts and tumors from similar lesions

Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation

Introduction: Cell division cycle-7 protein is a serine/threonine kinase that has a basic role in cell cycle regulation and is a potential prognostic or therapeutic target in some human cancers. Objectives: This study investigated the expression of cell division cycle-7 protein in benign and malignant salivary gland tumors and also its correlation with clinicopathologic factors. Methods: Immunohistochemical expression of cell division cycle-7 was evaluated in 46 cases, including 15 adenoid cystic carcinoma, 12 mucoepidermoid carcinoma, 14 pleomorphic adenoma, and 5 normal salivary glands. Cell division cycle-7 expression rate and intensity were compared statistically. Results: The protein was expressed in almost all tumors. The intensity and mean of cell division cycle-7 expression were higher in malignant tumors in comparison with pleomorphic adenomas (p = 0.000). The protein expression was correlated with tumor grades (p = 0.000). Conclusions: The present study demonstrated cell division cycle-7 overexpression in malignant salivary gland tumors in comparison with pleomorphic adenomas, and also a correlation with tumor differentiation. Therefore, this protein might be a potential prognostic and therapeutic target for salivary gland tumors. Resumo: Introdução: A cell division cycle-7 é uma serina/treonina quinase que tem um papel básico na regulação do ciclo celular e é um potencial marcador prognóstico ou terapêutico em alguns tipos de câncer humano. Objetivos: Este estudo investigou a expressão de cell division cycle-7 em tumores de glândulas salivares benignos e malignos e também sua correlação com fatores clínico-patológicos. Método: A expressão imuno-histoquímica de cell division cycle-7 foi avaliada em 46 casos, incluindo 15 carcinomas adenoide císticos, 12 carcinomas mucoepidermoides, 14 adenomas pleomórficos e 5 glândulas salivares normais. A taxa de expressão e a intensidade da proteína cell division cycle-7 foram comparadas estatisticamente. Resultados: A proteína foi expressa em quase todos os tumores. A intensidade e a média da expressão de cell division cycle-7 foram maiores em tumores malignos em comparação com adenoma pleomórfico (p = 0,000). A expressão da proteína foi correlacionada com os graus do tumor (p = 0,000). Conclusões: O presente estudo demonstrou a superexpressão de cell division cycle-7 em tumores malignos de glândulas salivares quando comparada com o adenoma pleomórfico, além de uma correlação com a diferenciação de tumores. Portanto, essa proteína pode ser um potencial marcador prognóstico e terapêutico para tumores de glândulas salivares. Keywords: Salivary gland, CDC7, Adenoid cystic carcinoma, Mucoepidermoid carcinoma, Pleomorphic adenoma, Palavras-chave: Glândula salivar, CDC7, Carcinoma adenoide cístico, Carcinoma mucoepidermoide, Adenoma pleomórfic

Immunohistochemical expression of CDC7 in dentigerous cyst, odontogenic keratocyst and radicular cyst

we desigened a retospective study, an d used cdc7 immunohistochemically on some common odontogenic cysts

Evaluation of Odontogenic Tumors Frequency in Biopsies Sent to Isfahan, Shiraz and Yazd Dental Schools

Odontogenic cysts and tumors are lesions found in the upper and lower jaw and oral soft tissue. The understanding and correct diagnosis of odontogenic tumors is essential because they can be invasive or recurrent in nature and evenrarely show malignant changes. The aim of this study was to evaluate the frequency of odontogenic tumors in Isfahan, Shiraz and Yazd cites.Materials & Methods:This is a cross-sectional descriptive-analytical study that was performed in the mentioned centers. The records of registered samples from the first year of establishment to 2018 have been reviewed which is approximately 18,000 cases. Samples data were extracted and recorded based on sex, age, jaw and location of involvement in affected jaw. Data were analyzed using descriptive statistics and Chi-square test (p value < 0.05).Results:In this study, a total of 498 odontogenic tumors were evaluated. The number of odontogenic tumors in Isfahan, Shiraz and Yazd cities was 313, 130 and 55, respectively. The mean age of the patients was 30.1 ± 15.9 and most of the patients were in the age group of 20 to 40 years and 53.4% were female. The most common sites of involvement were the right mandibular (29.1%) and then the left mandibular (28.3%) and the most common tumor was ameloblastoma (50.2%) and then complex odontoma (16.7%).Conclusion:Due to the frequency observed for odontogenic tumors, understanding the clinical and pathologic features of these lesions is essential for rapid and appropriate diagnosis and treatment