444 research outputs found
Modelling Molecular Motors as Folding-Unfolding Cycles
We propose a model for motor proteins based on a hierarchical Hamiltonian
that we have previously introduced to describe protein folding. The proposed
motor model has high efficiency and is consistent with a linear load-velocity
response. The main improvement with respect to previous models is that this
description suggests a connection between folding and function of allosteric
proteins.Comment: 5 pages RevTeX, 2 Postscript figures, replaced due to LaTeX proble
On the density profile of the globular cluster M92
We present new number density and surface brightness profiles for the
globular cluster M92 (NGC 6341). These profiles are calculated from optical
images collected with the CCD mosaic camera MegaCam at the
Canada-France-Hawaii-Telescope and with the Advanced Camera for Surveys on the
Hubble Space Telescope. The ground-based data were supplemented with the Sloan
Digital Sky Survey photometric catalog. Special care was taken to discriminate
candidate cluster stars from field stars and to subtract the background
contamination from both profiles. By examining the contour levels of the number
density, we found that the stellar distribution becomes clumpy at radial
distances larger than about 13 arcminutes, and there is no preferred
orientation of contours in space. We performed detailed fits of King and Wilson
models to the observed profiles. The best-fit models underestimate the number
density inside the core radius. Wilson models better represent the
observations, in particular in the outermost cluster regions: the good global
agreement of these models with the observations suggests that there is no need
to introduce an extra-tidal halo to explain the radial distribution of stars at
large radial distances. The best-fit models for the number density and the
surface brightness profiles are different, even though they are based on the
same observations. Additional tests support the evidence that this fact
reflects the difference in the radial distribution of the stellar tracers that
determine the observed profiles (main sequence stars for the number density,
bright evolved stars for the surface brightness).Comment: 18 pages, 10 figures, Accepted by A
Of mice and humans through the looking glass: "reflections" on epigenetics of lipid metabolism
Over the past decade, epigenetics has emerged as a new layer of regulation of gene expression. Several investigations demonstrated that nutrition and lifestyle regulate lipid metabolism by influencing epigenomic remodeling. Studies on animal models highlighted the role of epigenome modifiers in specific metabolic contexts and established clear links between dysregulation of epigenetic mechanisms and metabolic dysfunction. The relevance of findings in animal models has been translated to humans, as epigenome-wide association studies (EWAS) deeply investigated the relationship between lifestyle and epigenetics in human populations. In this review, we will provide an outlook of recent studies addressing the link between epigenetics and lipid metabolism, by comparing results obtained in animal models and in human subjects
Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors
Patients with paroxysmal nocturnal hemoglobinuria (PNH) have a large clonal population of blood cells deriving from hematopoietic stem cells (HSCs) deficient in glycosylphosphatidylinositol (GPI)-anchored surface molecules. A current model postulates that PNH arises through negative selection against normal HSCs exerted by autoreactive T cells, whereas PNH HSCs escape damage. We have investigated the inhibitory receptor superfamily (IRS) system in 13 patients with PNH. We found a slight increase in the proportion of T cells expressing IRS. In contrast to what applies to healthy donors, the engagement of IRS molecules on T cells from patients with PNH elicited a powerful cytolytic activity in a redirected killing assay, indicating that these IRSs belong to the activating type. This was confirmed by clonal analysis: 50% of IRS+ T-cell clones in patients with PNH were of the activating type, while only 5% were of the activating type in healthy donors. Moreover, the ligation of IRS induces (1) production of tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) and (2) brisk cytolytic activity against cells bearing appropriate IRS counter-ligands. In addition, these IRS+ T cells show natural killer (NK)-like cytolytic activity to which GPI- cells were less sensitive than GPI+ cells. Thus, T cells with NK-like features, expressing the activating isoforms of IRS, may include effector cells involved in the pathogenesis of PNH
The energy budget in Rayleigh-Benard convection
It is shown using three series of Rayleigh number simulations of varying
aspect ratio AR and Prandtl number Pr that the normalized dissipation at the
wall, while significantly greater than 1, approaches a constant dependent upon
AR and Pr. It is also found that the peak velocity, not the mean square
velocity, obeys the experimental scaling of Ra^{0.5}. The scaling of the mean
square velocity is closer to Ra^{0.46}, which is shown to be consistent with
experimental measurements and the numerical results for the scaling of Nu and
the temperature if there are strong correlations between the velocity and
temperature.Comment: 5 pages, 3 figures, new version 13 Mar, 200
Why the ongoing occupation of Ukraine matters to ethnobiology
Ethnobiology and ethnomedicine investigate the continuously changing complex and inextricable relations among culture, nature, and health. Since the emergence of modern ethnobiology a few decades ago, its essence and mission have been the study of biocultural diversities and the centers of its inquiries have been and are local communities and their co-evolutionary interrelationships between natural environments and social systems. At the core of ethnobiologists’ work there are not only conceptualizations of and reflections on others' views about nature and the universe, but also a robust commitment to advocacy in defense of these assemblages of local ecological knowledge, practices, and beliefs (LEK). Homogenization processes and therefore erosion of LEK have occurred throughout history in different ways: from colonialism to industrialization, and from financialization to globalization; however, we cannot forget the role played by centripetal states and even dictatorships in this process, nor the associated political ideology of nationalism, which has often elicited and justified policies aimed at standardizing diversities within state borders. Our research groups have been working since eight years together with local communities in Ukrainian rural areas and documented a remarkable erosion of LEK during the Soviet times, yet an extraordinary surviving biocultural diversity occurs; the ongoing military occupation of Ukraine could further threaten this heritage. While citizens’ attention now should be on effectively supporting those who are experiencing hardships during this traumatic time, ethnobiologists will be called hopefully soon to directly participate in rebuilding the biocultural “cobwebs” damaged by the military operations
Periodically kicked turbulence
Periodically kicked turbulence is theoretically analyzed within a mean field
theory. For large enough kicking strength A and kicking frequency f the
Reynolds number grows exponentially and then runs into some saturation. The
saturation level can be calculated analytically; different regimes can be
observed. For large enough Re we find the saturation level to be proportional
to A*f, but intermittency can modify this scaling law. We suggest an
experimental realization of periodically kicked turbulence to study the
different regimes we theoretically predict and thus to better understand the
effect of forcing on fully developed turbulence.Comment: 4 pages, 3 figures. Phys. Rev. E., in pres
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