In vivo antidiabetic activity of qwueous extract of Artemisia argyi (Chinese mugwort) in alloxan-induced diabetic rats

Purpose: To determine the antidiabetic, antioxidant and anti-hyperlipidemic effects of aqueous leaf extract of Artemisia argyi (Asteraceae) in alloxan (ALX)-induced diabetic rats. Experimental: Soxhlet apparatus was packed with grinded leaves of A. Argyi and subjected to extraction by double distillation using water as  running solvent for 4 – 5 h. Male albino Wistar rats weighing 150 ± 10 g were used in this study. Diabetes was induced in overnight-fasted rats via intraperitoneal administration of freshly prepared 10 % alloxan solution at a dose of 186.9 mg/kg. Serum glucose (Glc), high-density lipoprotein cholesterol (HDL-c), triglycerides (TGs) and total cholesterol (TC) were evaluated using Randox assay kits. Serum reduced glutathione (GSH) was assayed using a slight modification of a previously reproted procedure, while histological examination was carried out microscopically after hematoxylin and eosin staining. Results: Oral administration of aqueous extract of Artemisia argyi significantly reduced ALX-induced increases in glycosylated hemoglobin and blood glucose, but significantly increased total protein, hemoglobin, insulin, and C-peptide levels (p < 0.05). Administration of the extract also led to a significant upsurge in non-enzymic antioxidants i.e. ceruloplasmin, GSH, vitamin E and vitamin C. The extract produced a hypolipidemic effect by significantly reducing total cholesterol (TC) and serum TGs. The hypoglycemic and hypolipidemic effects of the extract were dose-dependent (p < 0.05). Histological examination of the pancreas revealed that the extract protected the integrity of beta cells in ALXinduced diabetic rats. Conclusion: These results indicate the beneficial effects of Artemisia argyi against diabetes mellitus. Thus, Artemisia argyi may be useful in the management of diabetes mellitus. Keywords: Artemisia argyi, Antidiabetic, Glutathione, Histopathology, Antioxidan

"I'm the Jedi!" - A Case Study of User Experience in 3D Tele-immersive Gaming

Abstract—In this paper, we present the results from a quantitative and qualitative study of distributed gaming in 3D tele-immersive (3DTI) environments. We explore the Qual-ity of Experience (QoE) of users in the new cyber-physical gaming environment. Guided by a theoretical QoE model, we conducted a case study and evaluated the impact of various Quality of Service (QoS) metrics (e.g., end-to-end delay, visual quality, etc.) on 3DTI gaming experience. We also identified a number of non-technical factors that are not captured by the original theoretical model, such as age, social interaction, and physical setup. Our analysis highlights new implications for the next-generation gaming system design, as well as a more comprehensive conceptual framework that captures non-technical influences for user experience in such environments

A Drive to Driven Model of Mapping Intraspecific Interaction Networks.

Community ecology theory suggests that an individual\u27s phenotype is determined by the phenotypes of its coexisting members to the extent at which this process can shape community evolution. Here, we develop a mapping theory to identify interaction quantitative trait loci (QTL) governing inter-individual dependence. We mathematically formulate the decision-making strategy of interacting individuals. We integrate these mathematical descriptors into a statistical procedure, enabling the joint characterization of how QTL drive the strengths of ecological interactions and how the genetic architecture of QTL is driven by ecological networks. In three fish full-sib mapping experiments, we identify a set of genome-wide QTL that control a range of societal behaviors, including mutualism, altruism, aggression, and antagonism, and find that these intraspecific interactions increase the genetic variation of body mass by about 50%. We showcase how the interaction QTL can be used as editors to reconstruct and engineer new social networks for ecological communities

Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells

© 2015 Xiao et al.; licensee Biomed Central. Successful expansion of hematopoietic stem cells (HSCs) would benefit the use of HSC transplants in the clinic. Angiopoietin-like 7 promotes the expansion of hematopoietic stem and progenitor cells (HSPC) in vitro and ex vivo. However, the impact of loss of Angptl7 on HSPCs in vivo has not been characterized. Here, we generated Angptl7-deficient mice by TALEN-mediated gene targeting and found that HSC compartments in Angptl7-null mice were compromised. In addition, wild type (WT) HSPCs failed to repopulate in the BM of Angptl7-null mice after serial transplantations while the engraftment of Angptl7-deficient HSPCs in WT mice was not impaired. These results suggest that Angptl7 is required for HSPCs repopulation in a non-cell autonomous manner.Link_to_subscribed_fulltex

Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments

© 2015 Ye et al. Background: The mouse is an organism that is widely used as a mammalian model for studying human physiology or disease, and the development of immunodeficient mice has provided a valuable tool for basic and applied human disease research. Following the development of large-scale mouse knockout programs and genome-editing tools, it has become increasingly efficient to generate genetically modified mouse strains with immunodeficiency. However, due to the lack of a standardized system for evaluating the immuno-capacity that prevents tumor progression in mice, an objective choice of the appropriate immunodeficient mouse strains to be used for tumor engrafting experiments is difficult. Methods: In this study, we developed a tumor engraftment index (TEI) to quantify the immunodeficiency response to hematologic malignant cells and solid tumor cells of six immunodeficient mouse strains and C57BL/6 wild-type mouse (WT). Results: Mice with a more severely impaired immune system attained a higher TEI score. We then validated that the NOD-scid-IL2Rg-/- (NSI) mice, which had the highest TEI score, were more suitable for xenograft and allograft experiments using multiple functional assays. Conclusions: The TEI score was effectively able to reflect the immunodeficiency of a mouse strain.Link_to_subscribed_fulltex

Understanding the Human Perceptions in Tele-Immersive Shared Activity

Both comparative category rating (CCR) and degradation category rating (DCR) methods have been heavily employed in the subjective evaluations of media systems. The resulting metrics, comparative mean-opinion-score (CMOS) and degradation mean-opinion-score (DMOS), can be used to describe the system subjective quality. However, the subjective metrics may work unsuccessfully when the variance of participant votes is large. The diversity in human interests can appear due to the tradeoffs of multiple quality dimensions, which concurrently dominate the overall quality of the media system. In this paper, we conduct a user study with 19 participants to evaluate the subjective quality of two tele-immersive shared activities (TISA), where media samples of different qualities are evaluated in case of each activity. Our study aims at (1) showing the effectiveness and limitation of CMOS and DMOS using real subjective data, and (2) demonstrating the heterogeneous impacts of TISAs on human perceptions.NSF CNS 0834480, 0964081, 1012194, IIP 1110178published or submitted for publicationnot peer reviewe

The developement of lightweight cementitious cellular composites(LCCCs)

This research focuses on developing architected lightweight cementitious cellular composites (LCCCs) for potential thermal insulation purposes. Specifically, Voronoi cellular structures with different randomness are adopted and used as cellular structure of the LCCCs. the mechanical properties of the developed LCCCs are investigated by experimental and numerical methods. With the help of 3D printing technique, LCCCs are prepared with two mixtures: a reference mortar, denoted as REF and mortar incorporating microencapsulated phase change materials (mPCMs), denoted as PCM14. Mechanical properties of developed structures are first investigated. The compressive behaviour of the LCCCs is investigated at the age of 28 days. In general, the LCCCs show anisotropic compressive behaviour in two loading directions: the compressive strength and stiffness of the LCCCs in the out-of-plane direction is substantially higher than that of the in-plane direction. Comparing to conventional foam concrete with the same density, the out-of-plane compressive strength of the LCCCs is higher than commonly reported cases in literature. Due to the high porosity of the cellular structures, the compressive strength of the LCCCs is significantly reduced comparing to the corresponding constituent materials, as expected. In addition, this strength reduction of the LCCCs made with PCM14 is substantially lower than the that of the REF samples. Interestingly, the relative stiffness (measured stiffness of the LCCCs normalized by their porosity) of the mPCMs incorporated LCCCs is even higher than the constituent material E-modulus. Furthermore, the critical role of air voids on the compressive behaviour of the LCCCs is identified. The thermal conductivity of the LCCCs is investigated by numerical models using commercial software Abaqus and ANSYS. It is found that the thermal conductivity of the LCCCs is comparable with the conventional foam concrete of the same density. The geometry heterogeneity of the LCCCs has a minor effect on determining the thermal conductivity of the LCCCs. Moreover, increasing porosity or reducing thermal bridge on the heat transfer direction can dramatically improve the thermal insulation performance of the LCCCs. It is found that the natural convection of the air within the cellular pores and the radiation has less notable effect on the thermal conductivity of specimen. Comparing to the REF, PCM14 has enhanced thermal insulation performance. In the end, using extrusion-based 3D concrete printing technique, the LCCCs with mPCMs has been successfully printed as an implement of manufacturing LCCCs as a construction-scale brick. In general, the developed LCCCs have high porosity gives good insulation properties as well as good compressive strength. This gives them great potential to be used as novel lightweight thermal insulation materials for construction.Civil Engineering | Building Engineerin

Span-Based Semantic Role Labeling with Argument Pruning and Second-Order Inference

We study graph-based approaches to span-based semantic role labeling. This task is difficult due to the need to enumerate all possible predicate-argument pairs and the high degree of imbalance between positive and negative samples. Based on these difficulties, high-order inference that considers interactions between multiple arguments and predicates is often deemed beneficial but has rarely been used in span-based semantic role labeling. Because even for second-order inference, there are already O(n^5) parts for a sentence of length n, and exact high-order inference is intractable. In this paper, we propose a framework consisting of two networks: a predicate-agnostic argument pruning network that reduces the number of candidate arguments to O(n), and a semantic role labeling network with an optional second-order decoder that is unfolded from an approximate inference algorithm. Our experiments show that our framework achieves significant and consistent improvement over previous approaches

Mechanical Properties of Lightweight Cementitious Cellular Composites Incorporating Micro-Encapsulated Phase Change Material

This work focuses on combining digitally architected cellular structures with cementitious mortar incorporating micro-encapsulated phase change material (mPCM) to fabricated lightweight cementitious cellular composites (LCCCs). Voronoi structures with different randomness are designed for the LCCCs. Aided by the indirect 3D printing technique, the LCCCs were prepared with a reference mortar (REF) and a mortar incorporating mPCM. The compressive behavior of the LCCCs was studied at the age of 28 days, by experimental and numerical methods. It was found that the highly randomized Voronoi structure and the mPCM have minor negative influence on the compressive properties of the LCCCs. The mPCM incorporated LCCCs have high relative compressive strength compared to conventional foam concrete. Furthermore, the critical role of air voids defects on the compressive behavior was identified. The highly randomized porous Voronoi structure, high mPCM content and good compressive strength ensure the LCCCs’ great potential as a novel thermal insulation construction material.Materials and Environmen