Tout n’est pas si noir dans cet Atlantique… noir !Du Bandit au Rebelle : transformations de la masculinité dans la musique reggae Dancehall

À contre-courant des discours essentialistes et des explications racialistes sur la responsabilité envers les victimes et/ou des auteurs de violences, ma contribution analysera les formations textuelles et performatives de la violence dans la musique reggae dancehall. Dans cette perspective, je m’intéresserai aux influences tant extérieures que locales, qui contribuent à la construction d’une figure complexe qu’est celle du « Rude Boy ». J’analyserai cette identité sous l’angle des théories de la pratique, notamment à travers le concept bourdieusien d’habitus. La figure du « Rude Boy », analysée sous le prisme de ces « outils analytiques », devrait permettre de questionner certaines des hypothèses paradigmatiques autour du concept d’hybridité développé par Paul Gilroy dans son ouvrage majeur L’Atlantique Noir – Modernité et Double conscience, et qu’il oppose à la revendication de l’« authenticité » d’une pensée essentialiste et nationaliste

Donna Hope (ed.), Reggae from Yaad. Traditional and Emerging Themes in Jamaican Popular Music

Reggae from Yaad offers a gathering of Caribbean and international scholars involving some key practitioners and historical agents into a broad reasoning on the ramified pathways (or “trods”) of reggae music. Donna Hope has to be hailed for editing this enlightening volume on important historical experiences and developments still (fairly) untold and the current contentious issues encompassing the sexual politics of reggae music (including dancehall). As perhaps the most prolific cultural cri..

There ain’t just Black in the Atlantic, Jack! Transformations of Masculinity from the Outlaw to the Rebel in Dancehall Reggae

À contre-courant des discours essentialistes et des explications racialistes sur la responsabilité envers les victimes et/ou des auteurs de violences, ma contribution analysera les formations textuelles et performatives de la violence dans la musique reggae dancehall. Dans cette perspective, je m’intéresserai aux influences tant extérieures que locales, qui contribuent à la construction d’une figure complexe qu’est celle du « Rude Boy ». J’analyserai cette identité sous l’angle des théories de la pratique, notamment à travers le concept bourdieusien d’habitus. La figure du « Rude Boy », analysée sous le prisme de ces « outils analytiques », devrait permettre de questionner certaines des hypothèses paradigmatiques autour du concept d’hybridité développé par Paul Gilroy dans son ouvrage majeur L’Atlantique Noir – Modernité et Double conscience, et qu’il oppose à la revendication de l’« authenticité » d’une pensée essentialiste et nationaliste

The Eulerian Stochastic Fields Method Applied to Large Eddy Simulations of a Piloted Flame with Inhomogeneous Inlet

Large Eddy Simulations of the Sydney mixed-mode flame with inhomogeneous inlet (FJ200-5GP-Lr75-57) are performed using the Eulerian Stochastic Fields (ESF) transported probability functions method to account for the sub-grid scale turbulence–chemistry interaction, to demonstrate the suitability of the ESF method for mixed-mode combustion. An analytically reduced 19-species methane mechanism is used for the description of the chemical reactions. Prior to the reactive case, simulation results of the non-reactive setup with cold and hot pilot stream are presented, which show differences in the jet breakup and radial species mass fluxes. The reactive case simulations are compared to experimental data and a recently conducted model free quasi-DNS (qDNS), showing very good agreement with the qDNS in terms of scatter data and radial mean values of temperature and species distribution, as well as mixture fraction conditional statistics. Further analysis is dedicated to sub-grid scale statistics, showing that mixture fraction and reaction progress variable are strongly correlated in this flame. The impact of the number of stochastic fields on the filtered temperature and species distribution is investigated; it reveals that the ESF method in conjunction with finite-rate chemistry is very insensitive to the number of employed fields to obtain highly accurate simulation results

Protocol of a phase II trial

Background Current studies on salvage radiotherapy (sRT) investigate timing, dose-escalation and anti-hormonal treatment (ADT) for recurrent prostate cancer. These approaches could either be limited by radiation-related susceptibility of the anastomosis or by suspected side-effects of long-term ADT. A phase II protocol was developed to investigate the benefit and tolerability of regional hyperthermia with moderately dose-escalated radiotherapy. Methods The study hypothesis is that radio-thermotherapy is a safe and feasible salvage treatment modality. The primary endpoint is safety measured by frequency of grade 3+ genitourinary (GU) and gastrointestinal (GI) adverse events (AE) according to Common Toxicity Criteria (CTC) version 4. Feasibility is defined by number of hyperthermia treatments (n ≥ 7) and feasibility of radiotherapy according to protocol. Target volume delineation is performed according to the EORTC guidelines. Radiation treatment is administered with single doses of 2 Gy 5×/week to a total dose of 70 Gy. Regional hyperthermia is given 2×/week to a total of 10 treatments. Results European centres participate in the phase II trial using intensity modulated RT (IMRT) or volumetric modulated arc technique (VMAT). The initiating centres were participants of the SAKK 09/10 study, where the same patient criteria and target volume definition (mandatory successful performed dummy run) were applied insuring a high standardisation of the study procedures. Conclusions The introduced phase II study implements highly precise image-guided radiotherapy and regional hyperthermia. If the phase II study is found to be safe and feasible, a multicenter phase III study is planned to test whether the addition of regional hyperthermia to dose-intensified sRT improves biochemical control

Sarcoma classification by DNA methylation profiling in clinical everyday life: the Charité experience

Background: Sarcomas are a heterogeneous group of rare malignant tumors with more than 100 subtypes. Accurate diagnosis remains challenging due to a lack of characteristic molecular or histomorphological hallmarks. A DNA methylation-based tumor profiling classifier for sarcomas (known as sarcoma classifier) from the German Cancer Research Center (Deutsches Krebsforschungszentrum) is now employed in selected cases to guide tumor classification and treatment decisions at our institution. Data on the usage of the classifier in daily clinical routine are lacking. Methods: In this single-center experience, we describe the clinical course of five sarcoma cases undergoing thorough pathological and reference pathological examination as well as DNA methylation-based profiling and their impact on subsequent treatment decisions. We collected data on the clinical course, DNA methylation analysis, histopathology, radiological imaging, and next-generation sequencing. Results: Five clinical cases involving DNA methylation-based profiling in 2021 at our institution were included. All patients' DNA methylation profiles were successfully matched to a methylation profile cluster of the sarcoma classifier's dataset. In three patients, the classifier reassured diagnosis or aided in finding the correct diagnosis in light of contradictory data and differential diagnoses. In two patients with intracranial tumors, the classifier changed the diagnosis to a novel diagnostic tumor group. Conclusions: The sarcoma classifier is a valuable diagnostic tool that should be used after comprehensive clinical and histopathological evaluation. It may help to reassure the histopathological diagnosis or indicate the need for thorough reassessment in cases where it contradicts previous findings. However, certain limitations (non-classifiable cases, misclassifications, unclear degree of sample purity for analysis and others) currently preclude wide clinical application. The current sarcoma classifier is therefore not yet ready for a broad clinical routine. With further refinements, this promising tool may be implemented in daily clinical practice in selected cases