1,009 research outputs found

    Participatory modelling in an introductory systems thinking and system dynamics class

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    In the system dynamics field there is a rich literature on participatory system dynamics / group model building and a rich literature on teaching students system dynamics. However, these two have not yet been combined and there is a lack of insights on using participatory system dynamics in a teaching context. This paper starts to close this gap by reporting two examples of participatory system dynamics teaching. It discusses the purposes of such kind of teaching, relating it to the different components of teaching participatory modelling vs. using a participatory process to teach system dynamics concepts as well as the learning objectives related to participatory process vs. model content vs. system dynamics insights

    Theorising and modelling competing institutional logics in decision-making

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    Dealing with soft variables and data scarcity: Lessons learnt from the quantification in a participatory System Dynamics model

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    System Dynamics simulation models are commonly used for exploring, structuring and managing complex problems in order to design more effective policies and inform decision-making. They are often used to investigate areas in which limited knowledge is available, describing nonlinear relationships and including variables representing intangible elements of the system. Indeed, SD practitioners build and depend on formal simulation models to overcome the cognitive limitations to grasp the dynamic complexity of the problem situation, and to make reliable behavioural inferences. While this explorative nature is one of the key advantages of SD models, it also represents a major challenge for modellers working on the quantification and parametrization of the qualitative aspects of a (participatory) model, namely soft variables and data scarce contexts, especially when it is not possible to apply conventional analytical methods. There is a limited availability of procedures to obtain and analyse qualitative information. This paper investigates quantification good practices; on the other side, it describes a quantification process carried out during a participatory SD modelling process on the use of natural space in Thamesmead, an area undergoing urban regeneration in London, United Kingdom

    Global existence for long wave Hopf unstable spatially extended systems with a conservation law

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    We are interested in reaction-diffusion systems, with a conservation law, exhibiting a Hopf bifurcation at the spatial wave number k=0k = 0. With the help of a multiple scaling perturbation ansatz a Ginzburg-Landau equation coupled to a scalar conservation law can be derived as an amplitude system for the approximate description of the dynamics of the original reaction-diffusion system near the first instability. We use the amplitude system to show the global existence of all solutions starting in a small neighborhood of the weakly unstable ground state for original systems posed on a large spatial interval with periodic boundary conditions

    Interaktionspartner des Kationenkanals TRPC4

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    Generalized resistance to pruritogen-induced scratching in the C3H/HeJ strain

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    Previously the effect of the pruritogens, such as histamine and chloroquine, was tested in 11 inbred mouse strains, and this study aimed to identify resistant and sensitive strains, consistent with the observation that underlies the large variability in human populations. In the present study, we used the low responder C3H/HeJ (C3H) and the more sensitive C57BL/6J (C57) strain to find out if resistance and sensitivity to develop pruritus is restricted to only histamine and chloroquine or extends to other known pruritogens as well. We tested five additional commonly known pruritogens. We established dose-response relationships by injecting four concentrations of the pruritogens in the range of 0.3, 1, 3, and ten-fold in the nuchal fold. Then we assessed the scratching behavior for 30 min after injection with an automated custom-designed device based on the bilateral implantation of mini-magnets in the hind paws and on single cages placed within a magnetic coil. We found that the resistance to pruritogens is a general phenotype of the C3H strain and extends to all pruritogens tested, including not only histamine and chloroquine, but also endothelin, trypsin, 5-HT (serotonin), the short peptide SLIGRL, and Lysophosphatidic acid (LPA). C57 was more sensitive to all pruritogens and, in contrast to C3H, dose-response relationships were evident for some of the pruritogens. In general, comparable peak scratch responses were observed for the 0.3-fold concentrations of the pruritogens in C57 whereas C3H required at least the ten-fold concentration and still displayed only between 5 and 33% of the scratch responses observed in C57 for the respective pruritogen. The general resistance to pruritogens and the low level of scratching behavior found in the C3H strain is an interesting trait and represents a model for the study of the heritability of itch. It is accompanied in C3H with a higher sensitivity in assays of nociception

    Determinants of successful breastfeeding initiation in healthy term singletons: a Swiss university hospital observational study

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    Aims: Breastfeeding significantly benefits mothers and infants. We aimed to identify the determinants of its successful initiation. Methods: A retrospective study of 1893 mothers delivering healthy term singletons at a Swiss university hospital from 1/2008 to 3/2009 determined the associations between multiple breastfeeding and early postpartum parameters by univariate and multiple regression analysis. Results: Multiparity was associated with nursing exclusively at the breast at discharge (P<0.001), less use of maltodextrin supplement (P<0.05), bottle/cup (both P<0.001), but more pacifier use (P<0.05). Among obese mothers, nursing exclusively at the breast at discharge was less frequent, and use of all feeding aids more frequent, than among normal-weight women (both P<0.001). Neuraxial anesthesia was associated with use of maltodextrin and bottle (both P<0.05) compared to no anesthesia. Delayed first skin-to-skin contact and rooming-in for <24 h/day were each associated with maltodextrin and cup (P<0.05). Nursing exclusively at the breast at discharge was less frequent (P<0.001), and bottle use more frequent (P<0.05), in women with sore nipples than in those without. Conclusions: Obesity is a potent inhibitor of breastfeeding initiation. Delivery without anesthesia by a multiparous normal-weight mother, followed by immediate skin-to-skin contact, rooming-in for 24 h/day, and dedicated nipple care, provides the best conditions for successful early postpartum breastfeeding without the need for feeding aids or nutritional supplement
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