23 research outputs found
Turnover of grassland roots in mountain ecosystems revealed by their radiocarbon signature: role of temperature and management
Root turnover is an important carbon flux component in grassland ecosystems because it
replenishes substantial parts of carbon lost from soil via heterotrophic respiration and leaching.
Among the various methods to estimate root turnover, the root’s radiocarbon signature
has rarely been applied to grassland soils previously, although the value of this approach is
known from studies in forest soils. In this paper, we utilize the root’s radiocarbon signatures,
at 25 plots, in mountain grasslands of the montane to alpine zone of Europe.We place the
results in context of a global data base on root turnover and discuss driving factors. Root
turnover rates were similar to those of a subsample of the global data, comprising a similar
temperature range, but measured with different approaches, indicating that the radiocarbon
method gives reliable, plausible and comparable results. Root turnover rates (0.06–1.0 y-1)
scaled significantly and exponentially with mean annual temperatures. Root turnover rates
indicated no trend with soil depth. The temperature sensitivity was significantly higher in
mountain grassland, compared to the global data set, suggesting additional factors influencing
root turnover. Information on management intensity from the 25 plots reveals that root
turnover may be accelerated under intensive and moderate management compared to low
intensity or semi-natural conditions. Because management intensity, in the studied ecosystems,
co-varied with temperature, estimates on root turnover, based on mean annual temperature
alone, may be biased. A greater recognition of management as a driver for root
dynamics is warranted when effects of climatic change on belowground carbon dynamics
are studied in mountain grasslands.KB received support from the Swiss National Science Foundation, project 200021-115891 (www.snf.ch). SM received support from the Swiss State Secretariat for Education and Research, project C07.0031 (www.sbfi.admin.ch). MTS received support from the Spanish Ministry of Science and Innovation, (project CAPAS, CGL2010-22378-C03- 01) (www.idi.mineco.gob.es)
The diagnostic value of liver biopsy
BACKGROUND: Since the introduction of molecular diagnostic tools such as markers for hepatitis C and different autoimmune diseases, liver biopsy is thought to be useful mainly for staging but not for diagnostic purposes. The aim was to review the liver biopsies for 5 years after introduction of testing for hepatitis C, in order to evaluate what diagnostic insights – if any – remain after serologic testing. METHODS: Retrospective review of all liver biopsies performed between 1.1.1995 and 31.12.1999 at an academic outpatient hepatology department. The diagnoses suspected in the biopsy note were compared with the final diagnosis arrived at during a joint meeting with the responsible clinicians and a hepatopathologist. RESULTS: In 365 patients, 411 diagnoses were carried out before biopsy. 84.4 % were confirmed by biopsy but in 8.8 %, 6.8 % and 10.5 % the diagnosis was specified, changed or a diagnosis added, respectively. Additional diagnoses of clinical relevance were unrecognized biliary obstruction and additional alcoholic liver disease in patients with chronic hepatitis C. Liver biopsy led to change in management for 12.1 % of patients. CONCLUSION: Even in the era of advanced virological, immunological and molecular genetic testing, liver biopsy remains a useful diagnostic tool. The yield is particularly high in marker negative patients but also in patients with a clear-cut prebiopsy diagnosis, liver biopsy can lead to changes in patient management
Pilot study on the comprehensive economic costs of major trauma: Consequential costs are well in excess of medical costs
BACKGROUND: Trauma care is expensive. However, reliable data on the exact lifelong costs incurred by a major trauma patient are lacking. Discussion usually focuses on direct medical costs--underestimating consequential costs resulting from absence from work and permanent disability. METHODS: Direct medical costs and consequential costs of 63 major trauma survivors (ISS >13) at a Swiss trauma center from 1995 to 1996 were assessed 5 years posttrauma. The following cost evaluation methods were used: correction cost method (direct cost of restoring an original state), human capital method (indirect cost of lost productivity), contingent valuation method (human cost as the lost quality of life), and macroeconomic estimates. RESULTS: Mean ISS (Injury Severity Score) was 26.8 +/- 9.5 (mean +/- SD). In all, 22 patients (35%) were disabled, causing discounted average lifelong total costs of USD 1,293,800, compared with 41 patients (65%) who recovered without any disabilities with incurred costs of USD 147,200 (average of both groups USD 547,800). Two thirds of these costs were attributable to a loss of production whereas only one third was a result of the cost of correction. Primary hospital treatment (USD 27,800 +/- 37,800) was only a minor fraction of the total cost--less than the estimated cost of police and the judiciary. Loss of quality of life led to considerable intangible human costs similar to real costs. CONCLUSIONS: Trauma costs are commonly underestimated. Direct medical costs make up only a small part of the total costs. Consequential costs, such as lost productivity, are well in excess of the usual medical costs. Mere cost averages give a false estimate of the costs incurred by patients with/without disabilities
Turnover of grassland roots in mountain ecosystems revealed by their radiocarbon signature: role of temperature and management
Does normalized signal intensity of cervical discs on T2 weighted MRI images change in whiplash patients?
Purpose
We tested the hypothesis that whiplash trauma leads to changes of the signal intensity of cervical discs in T2-weighted images.
Methods and materials
50 whiplash patients (18–65 years) were examined within 48 h after motor vehicle accident, and again after 3 and 6 months and compared to 50 age- and sex-matched controls. Signal intensity in ROI's of the discs at the levels C2/3 to C7/T1 and the adjacent vertebral bodies were measured on sagittal T2 weighted MR images and normalized using the average of ROI's in fat tissue. The contrast between discs and both adjacent vertebrae was calculated and disc degeneration was graded by the Pfirrmann-grading system.
Results
Whiplash trauma did not have a significant effect on the normalized signals from discs and vertebrae, on the contrast between discs and adjacent vertebrae, or on the Pfirrmann grading. However, the contrast between discs and adjacent vertebrae and the Pfirrmann grading showed a strong correlation. In healthy volunteers, the contrast between discs and adjacent vertebrae and Pfirrmann grading increased with age and was dependent on the disc level.
Conclusion
We could not find any trauma related changes of cervical disc signal intensities. Normalized signals of discs and Pfirrmann grading changed with age and varied between disc levels with the used MR sequence
Cervical muscle area measurements in whiplash patients: Acute, 3, and 6 months of follow-up
PURPOSE: To investigate the role of the cervical spine muscles in whiplash injury. We hypothesized that (i) cervical muscle hypotrophy would be evident after a 6-month follow-up and, (ii) cervical muscle hypotrophy would correlate with symptom persistence probably related to pain or inactivity. MATERIALS AND METHODS: Ninety symptomatic patients (48 females) were recruited from our emergency department and examined within 48 h, and at 3, and 6 months after a motor vehicle accident. MRI cross-sectional muscle area (CSA) measurements were performed bilaterally of the cervical extensor and sternocleidomastoid muscles using transverse STIR (Short Tau inversion Recovery) sequences at the C2 (deep and total dorsal cervical extensor muscles), C4 (sternocleidomastoid muscles) and C5 (deep and total dorsal cervical extensor muscles) levels. Two blinded raters independently performed the measurements at each time point. First, CSA changes over time were analyzed and, second, CSAs were correlated with clinical outcomes (EuroQuol, Whiplash Disability Score, neck pain intensity [VAS], cervical spine mobility). RESULTS: There was a high agreement of CSA measurements between the two raters. Women consistently had smaller CSAs than men. There were no significant changes of CSAs over time at any of the three levels. There were no consistent significant correlations of CSA values with the clinical scores at all time points except with the body mass index. CONCLUSION: Our results do not support a major role of cervical muscle volume in the genesis of symptoms after whiplash injury. J. Magn. Reson. Imaging 2012;. © 2012 Wiley Periodicals, Inc
Mean annual temperature and root carbon mean residence time (0–10 cm) of all sampling plots.
<p>The curve displays the exponential relationship mean residence time (y) = 13.38 [1.94] * exp(-0.24 [0.05] * x), R2 = 0.53,P < 0.001. Values in square brackets are 1 SE.</p
Normative MR cervical spinal canal dimensions
PURPOSE: To provide normal values of the cervical spinal canal and spinal cord dimensions in several planes with respect to spinal level, age, sex, and body height.
MATERIALS AND METHODS: This study was approved by the institutional review board; all individuals provided signed informed consent. In a prospective multicenter study, two blinded raters independently examined cervical spine magnetic resonance (MR) images of 140 healthy volunteers who were white. The midsagittal diameters and areas of spinal canal and spinal cord, respectively, were measured at the midvertebral levels of C1, C3, and C6. A multivariate general linear model described the influence of sex, body height, age, and spinal level on the measured values.
RESULTS: There were differences for sex, spinal level, interaction between sex and level, and body height, while age had significant yet limited influence. Normative ranges for the sagittal diameters and areas of spinal canal and spinal cord were defined at C1, C3, and C6 levels for men and women. In addition to a calculation of normative ranges for a specific sex, spinal level, age, and body height data, data for three different height subgroups at 45 years of age were extracted. These results show a range of the spinal canal dimensions at C1 (from 10.7 to 19.7 mm), C3 (from 9.4 to 17.2 mm), and C6 (from 9.2 to 16.8 mm) levels.
CONCLUSION: The dimensions of the cervical spinal canal and cord in healthy individuals are associated with spinal level, sex, age, and height. Online supplemental material is available for this article