393 research outputs found

    Approximation and convergence of solutions to semilinear stochastic evolution equations with jumps

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    We prove that the mild solution to a semilinear stochastic evolution equation on a Hilbert space, driven by either a square integrable martingale or a Poisson random measure, is (jointly) continuous, in a suitable topology, with respect to the initial datum and all coefficients. In particular, if the leading linear operators are maximal (quasi-)monotone and converge in the strong resolvent sense, the drift and diffusion coefficients are uniformly Lipschitz continuous and converge pointwise, and the initial data converge, then the solutions converge.Comment: 28 pages, no figure

    Circular health: a needed approach to promote health and prevent pandemics and other health hazards

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    SARS-Cov-2 is a perfect example of the intimate relationship between human, animal and environmental health. Circular health goes beyond the biomedical concept of health, operating on the interface between individuals, microorganisms and ecosystems. The World Health Organization endorses this concept and stresses the importance of protecting the environment and addressing and reversing the negative impact of climate change. The application of circular health to the governance for population health is based on protection of all forms of life, interdisciplinarity, involvement of all of society, big data, artificial intelligence, and correct scientific information. It also considers a combination of health, environmental, social and economic problems caused by the synergistic interaction between the acute diseases - in this case caused by SARS-Cov-2, and a number of non-transmittable chronic pathologies. Disinformation and misuse of social media could be more dangerous for the pandemic's development than the virus itself. The adoption of circular health is an urgent necessity in restructuring development policies and making them more effective and sustainable, and protecting and promoting individual and collective health. Within public health, circular health should urgently become the mainstream approach to prevent pandemics and other health hazards. Given the many social, economic, and cultural changes undergoing in the countries of the South-Eastern European Network the conceptual and policy framework related to circular health could be of great value in further advancing progress in this part of Europe

    Stochastic FitzHugh-Nagumo equations on networks with impulsive noise

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    We consider a system of nonlinear partial differential equations with stochastic dynamical boundary conditions that arises in models of neurophysiology for the diffusion of electrical potentials through a finite network of neurons. Motivated by the discussion in the biological literature, we impose a general diffusion equation on each edge through a generalized version of the FitzHugh-Nagumo model, while the noise acting on the boundary is described by a generalized stochastic Kirchhoff law on the nodes. In the abstract framework of matrix operators theory, we rewrite this stochastic boundary value problem as a stochastic evolution equation in infinite dimensions with a power-type nonlinearity, driven by an additive L\'evy noise. We prove global well-posedness in the mild sense for such stochastic partial differential equation by monotonicity methods.Comment: 18 pages. Minor revisio

    Socioenvironmental networks and international cooperation: The Global Alliance for Recycling and Sustainable Development- GARSD

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    Networks of nongovernmental organizations dedicated to socio-environmental issues have emerged in recent decades. The involvement of these networks in the international sphere has enabled new approaches to international cooperation. This article introduces the concept of international cooperation and the Global Alliance for Recycling and Sustainable Development (GARSD), a socio-environmental network created by a coalition of NGOs dedicated to promoting recycling of municipal solid waste. This article is the result of a doctoral study conducted using documentary analysis, participant observation and other qualitative data collection methods.  The study conclusively finds that it is neessary to analyze the work of these non-state actors within the context of international cooperation between nation states and the possibility of (re)creating political-territorial arrangements, such as networks comprising a variety of actors especially geared towards socio-environmental issues.  Durante as últimas décadas, surgiram redes de organizações não governamentais que se dedicam aos temas socioambientais. O envolvimento dessas redes com a esfera internacional ocasiona novas abordagens para a cooperação internacional. Apresentar o conceito de cooperação internacional e a rede socioambiental Global Alliance for Recycling and Sustainable Development - GARSD é o objetivo deste artigo. A GARSD, é resultado da coalização de organizações não governamentais dedicadas à promoção da reciclagem de resíduos sólidos urbanos. O artigo é o resultado de pesquisa realizada em processo de doutoramento, que utilizou por procedimentos metodológicos a análise documental, pesquisa participante e a coleta de dados de abordagem qualitativa.  Conclusivamente, torna-se inerente analisar as atuações destes atores não estatais diante das relações de cooperação internacional estabelecidas entre Estados Nacionais na possibilidade para a (re)criação de arranjos político-territoriais como a construção de redes entre os diversos atores, especialmente, nos temas socioambientais.

    Identifying features of the lentiviral genome crucial for the establishment of latency

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    Background Latently infected cells represent a major obstacle to the cure of infection with human immunodeficiency virus type 1 (HIV-1). We have observed that the propensity to establish latency varies greatly among primate lentiviruses. The purpose of our study is to identify the features that determine such variation in order to elucidate the fine molecular mechanisms regulating latency. Materials and methods Using GFP–encoding reporter viruses, the level of infection by SIV, HIV-1 and HIV-2 was quantitated by flow cytometry in cells stably expressing HIV-1 Tat, SIV Tat or vector alone. Results We have observed that SIVmac 239 infects human lymphoid cells much less efficiently than HIV-1. However, ectopic expression of HIV-1 Tat rescued SIV infection. As host cell type can influence viral gene expression, we tested different cell lines for their ability to support lentiviral latency. In both T (Jurkat TAg and C8166) and T-B hybrid cell lines (CEMX174) SIV exhibited a greater ability to remain transcriptionally silent within the human genome than HIV-1 or HIV-2. The different behaviour in terms of latency was particularly evident in CEMX174 cells, where HIV Tat activation caused more than 20-fold increase in the number of GFP-positive cells infected with SIV, while it had little effect on cells challenged with HIV-1 or HIV-2. The lower level of productive infection displayed by SIVmac239 was not due to a reduced ability of SIV Tat to trigger viral expression in human cells because SIV Tat overexpression reactivated latent SIV as well as HIV Tat did. Moreover, HIV-1 chimeric viruses harboring the U3 region of SIV behaved like the parental HIV-1 viruses, suggesting that viral determinants of SIV latency reside in a part of the lentiviral genome different from the promoter region. Conclusions In human cell lines transduction with SIVmac239 largely establishes a latent infection which is reactivated by overexpressing HIV-1 or SIVmac239 Tat. The tendency of SIVmac239 to establish latent infection is attributable neither to a defective SIV Tat activity nor to a reduced promoter activity of the U3 region in human lymphoid cells. The CEMX174 cell line offers a good model to explore the specific viral determinants which allow SIV to enter latency

    Comércio internacional de resíduos sólidos urbanos e a Convenção de Basileia: Contribuições sobre a poluição por óleo no litoral brasileiro

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    The Basel Convention (BC) states that the transboundary movement of wastes is only allowed if the wastes in question are required as a raw material. Any traffic of wastes in contravention of the Convention is considered criminal, resulting in illegal waste trafficking between countries. As signatory to the Convention, Brazil should take the necessary measures to regulate and monitor the transit of wastes for possible contraventions of the convention, such as the dumping of waste in its territorial seas. In light of the above, this bibliographic review provides an overview of the Basel Convention and documents the oil spill that occurred along the coast of Brazil in August 2019, seeking to theorize about the possibility of omission in relation to the Convention.O comércio internacional de resíduos é uma atividade praticada em âmbito global, porém, há de se afir­mar que a movimentação transfronteiriça de resíduos entre os países é considerada ilegal. Como resul­tado surge, no âmbito global, um comércio ilegal de lixo entre os países. Por outro lado, o trânsito de resíduos entre os países será permitido pela Convenção de Basileia (CB), quando for passível de uso como matéria-prima. Diante desse cenário, o presente artigo exibirá um panorama da Convenção de Basileia. O Brasil, signatário do documento, tem como premissa regular as atividades quanto ao trânsito de resíduos diante de possíveis ações que infiram na CB, como por exemplo, um possível despejamento de resíduos no mar territorial do país. Diante do apresentado, o artigo relata a poluição por óleo no litoral brasileiro, ocorrida em agosto de 2019. Como aspecto metodológico o artigo ampara-se em revisão documental e bibliográfica. Conclusivamente, apresenta-se um cenário sobre uma probabilidade de omissão da CB para os Estados Partes

    SEGURANÇA QUÍMICA NO BRASIL: AS CONVENÇÕES DE ROTERDÃ E ESTOCOLMO

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    The Rotterdam Convention on the Prior Informed Consent Procedure For Certain Hazardous Chemicals and Pesticides in International Trade (PIC), signed by Brazil in 1998, has in the transportation of toxic pesticides and dangerous chemicals substances traded internationally, its main element for discussion. The limitation of its use and/or the banning of certain Persistent Organic Pollutants (POPs) representative of a group of chemical products that convey serious threat to the living beings and the environment, are the topic of the Stockholm Convention.The Brazilian policy in relation to chemical security is not enough yet. Nevertheless, the concern with the environmental security is reaching the world dimension. key words : Rotterdam Convention (pic), Stockholm Convention on Persistent Organic Pollutants (pops), Environmental securityA Convenção de Roterdã sobre o Procedimento de Consentimento Fundamentado Prévio Aplicável a Certos Pesticidas e Produtos Químicos (PIC) , assinada pelo Brasil em 1998, tem no transporte dos pesticidas tóxicos e de substâncias químicas perigosas comercializadas internacionalmente seu principal elemento de discussão. Já a limitação do uso e/ou banimento de certos Poluentes Orgânicos Persistentes (POPs), representantes de uma classe de produtos químicos, que trazem sérias ameaças aos seres vivos e ao meio ambiente, são o objeto da Convenção de Estocolmo. A política brasileira em relação à segurança química ainda é insuficiente, embora a preocupação com a segurança ambiental venha alcançando a dimensão mundial somente nos últimos anos. Palavras chave: convenção de Roterdã (pic), Convenção de Estocolmo sobre poluentes orgânicos persistentes (pops), Segurança ambiental
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