Floodplain sediment from a 30-year-recurrence flood in 2005 of the Ping River in northern Thailand

International audienceThis paper documents the nature of flood-producing storms and floodplain deposition associated with the 28 September?2 October 2005 30-year-recurrence flood on the Ping River in northern Thailand. The primary purpose of the study is to understand the extent that deposits from summer-monsoon floods can be identified in floodplain stratigraphy A secondary objective is to document the sedimentation processes/patterns associated with a large contemporary flood event on a medium-sized Asian river. Maximum sediment depths of 15 cm were found on the river levee, within 30 m of the main channel, and at 350 m thickness was 4 cm. Sediment depth generally decreased exponentially with distance away from the main channel. The extent of sediment deposition was about 1 km from the river channel. However, 72% of the sediment was deposited within an oval-shaped area 200?400 m from the main channel and centered on a tributary stream, through which sediment-laden water entered the floodplain, in addition to overtopping the levee of the main channel. Sediment concentration during the flood was estimated at 800?1500 mg L?1; and we believe the sediment was delivered by flows of well-mixed flood water occurring over a 1?2 day period. These data suggest that flood-deposited strata related to 30-year recurrence floods is only likely to be preserved in deposits located relatively close to the main river channel where fine sand and clayey coarse silt deposits have thicknesses of at least 5?10 cm. These relatively thick deposits would survive bioturbation, whereas more distal areas with thin clayey silt deposits would not

Resistance mechanisms in BRAFV600E paediatric high-grade glioma and current therapeutic approaches

Paediatric high-grade gliomas (pHGG) are aggressive central nervous system tumours with a poor prognosis. BRAFV600E mutant pHGGs can be treated with targeted BRAF inhibitors, which have shown both preclinical activity and potent clinical efficacy. Unfortunately, the development of drug resistance results in disease relapse or progression and is the primary cause of treatment failure. While there is a lot of data to explain mechanisms of resistance in other BRAFV600E tumours, comparatively little is known about the mechanisms of BRAF inhibitor resistance in BRAFV600E pHGG. Recent literature has identified aberrations in members of the RAS/RAF/ERK pathway, the PI3K/AKT/MTOR pathway and the cell cycle as major contributors to the resistance profile. A range of novel therapies have been suggested to overcome BRAF inhibitor drug resistance in BRAFV600E pHGG. This review will discuss the current literature available for BRAF inhibitor resistant BRAFV600E pHGGs and provide an overview of the currently available and proposed therapies

Structural defects induced by Fe-ion implantation in TiO2

X-ray photoelectron spectroscopy (XPS) and resonant x-ray emission spectroscopy (RXES) measurements of pellet and thin film forms of TiO$_2$ with implanted Fe ions are presented and discussed. The findings indicate that Fe-implantation in a TiO$_2$ pellet sample induces heterovalent cation substitution (Fe$^{2+}\rightarrow$ Ti$^{4+}$) beneath the surface region. But in thin film samples, the clustering of Fe atoms is primarily detected. In addition to this, significant amounts of secondary phases of Fe$^{3+}$ are detected on the surface of all doped samples due to oxygen exposure. These experimental findings are compared with density functional theory (DFT) calculations of formation energies for different configurations of structural defects in the implanted TiO$_2$:Fe system. According to our calculations, the clustering of Fe-atoms in TiO$_2$:Fe thin films can be attributed to the formation of combined substitutional and interstitial defects. Further, the differences due to Fe doping in pellet and thin film samples can ultimately be attributed to different surface to volume ratios.Comment: 7+ pages, 3 Figure, to appear in J. Appl. Phy

Polytopality and Cartesian products of graphs

We study the question of polytopality of graphs: when is a given graph the graph of a polytope? We first review the known necessary conditions for a graph to be polytopal, and we provide several families of graphs which satisfy all these conditions, but which nonetheless are not graphs of polytopes. Our main contribution concerns the polytopality of Cartesian products of non-polytopal graphs. On the one hand, we show that products of simple polytopes are the only simple polytopes whose graph is a product. On the other hand, we provide a general method to construct (non-simple) polytopal products whose factors are not polytopal.Comment: 21 pages, 10 figure

Strong Balmer lines in old stellar populations: No need for young ages in ellipticals?

Comparing models of Simple Stellar Populations (SSP) with observed line strengths generally provides a tool to break the age-metallicity degeneracy in elliptical galaxies. Due to the wide range of Balmer line strengths observed, ellipticals have been interpreted to exhibit an appreciable scatter in age. In this paper, we analyze Composite Stellar Population models with a simple mix of an old metal-rich and an old metal-poor component. We show that these models simultaneously produce strong Balmer lines and strong metallic lines without invoking a young population. The key to this result is that our models are based on SSPs that better match the steep increase of Hbeta in metal-poor globular clusters than models in the literature. Hence, the scatter of Hbeta observed in cluster and luminous field elliptical galaxies can be explained by a spread in the metallicity of old stellar populations. We check our model with respect to the so-called G-dwarf problem in ellipticals. For a galaxy subsample covering a large range in UV-V colors we demonstrate that the addition of an old metal-poor subcomponent does not invalidate other observational constraints like colors and the flux in the mid-UV.Comment: Accepted for publication in ApJ Main Journal, 9 pages, 5 figure

Control of interlayer exchange coupling in Fe/Cr/Fe trilayers by ion beam irradiation

The manipulation of the antiferromagnetic interlayer coupling in the epitaxial Fe/Cr/Fe(001) trilayer system by moderate 5 keV He ion beam irradiation has been investigated experimentally. It is shown that even for irradiation with very low fluences (10^14 ions/cm^2) a drastic change in strength of the coupling appears. For thin Cr-spacers (below 0.6 - 0.7 nm) the coupling strength decreases with fluence, becoming ferromagnetic for fluences above (2x10^14 ions/cm^2). The effect is connected with the creation of magnetic bridges in the layered system due to atomic exchange events caused by the bombardment. For thicker Cr spacers (0.8 - 1.2 nm) an enhancement of the antiferromagnetic coupling strength is found. A possible explanation of the enhancement effect is given.Comment: Submitted to PR

Local Anesthetics and Recurrence after Cancer Surgery-What’s New? A Narrative Review

The perioperative use of regional anesthesia and local anesthetics is part of almost every anesthesiologist’s daily clinical practice. Retrospective analyses and results from experimental studies pointed towards a potential beneficial effect of the local anesthetics regarding outcome—i.e., overall and/or recurrence-free survival—in patients undergoing cancer surgery. The perioperative period, where the anesthesiologist is responsible for the patients, might be crucial for the further course of the disease, as circulating tumor cells (shed from the primary tumor into the patient’s bloodstream) might form new micro-metastases independent of complete tumor removal. Due to their strong anti-inflammatory properties, local anesthetics might have a certain impact on these circulating tumor cells, either via direct or indirect measures, for example via blunting the inflammatory stress response as induced by the surgical stimulus. This narrative review highlights the foundation of these principles, features recent experimental and clinical data and provides an outlook regarding current and potential future research activities

On the fundamental group of the complement of a complex hyperplane arrangement

We construct two combinatorially equivalent line arrangements in the complex projective plane such that the fundamental groups of their complements are not isomorphic. The proof uses a new invariant of the fundamental group of the complement to a line arrangement of a given combinatorial type with respect to isomorphisms inducing the canonical isomorphism of the first homology groups.Comment: 12 pages, Latex2e with AMSLaTeX 1.2, no figures; this last version is almost the same as published in Functional Analysis and its Applications 45:2 (2011), 137-14