Self-esteem, general and sexual self-concepts in blind people

Background: People with visual disability have lower self-esteem and social skills than sighted people. This study was designed to describe self-esteem and general and sexual self-concepts in blind people. Materials and Methods: This was a cross-sectional study, conducted in the Isfahan University of Medical Sciences in 2013-2014. In this study, 138 visually impaired people participated from Isfahan Province Welfare Organization and were interviewed for measuring of self-esteem and self-concept using Eysenck self-esteem and Rogers’ self-concept questionnaires. The correlation between above two variables was measured using Statistical Package for the Social Sciences (SPSS) software by Pearson correlation test. Results: Mean [± standard deviation (SD)] age of patients was 30.9 ± 8 years. The mean (±SD) of general self-concept score was 11 ± 5.83. The mean (±SD) of self-esteem score was 16.62 ± 2.85. Pearson correlation results showed a significant positive correlation between self-esteem and general self-concept (r = 0.19, P = 0.025). The mean of sexual self-concept scores in five subscales (sexual anxiety, sexual self-efficacy, sexual self-esteem, sexual fear, and sexual depression) were correspondingly 11 ± 4.41, 19.53 ± 4.53, 12.96 ± 4.19, 13.48 ± 1.76, and 5.38 ± 2.36. Self-esteem and self-concept had significant positive correlation with sexual anxiety (r = 0.49; P < 0.001) (r =-.23; P < 0.001) and sexual fear (r = 0.25; P = 0.003) (r = 0.18; P = 0.02) and negative correlation with sexual self-efficacy (r =-0.26; P = 0.002) (r =-0.28; P = 0.001) and sexual-esteem (r =-0.34; P < 0.001) (r =-0.34; P < 0.001). Conclusion: Self-esteem and self-concept had significant correlation with sexual anxiety and sexual fear; and negative correlation with sexual self-efficacy and sexual-esteem. © 2015 Journal of Research in Medical Sciences

Effect of interleukin-22 on immunogenicity of DNA vaccine encoding TSA gene of leishmania major in BALB/c mice

Background and purpose: Previous Research shows the use of plasmids containing genes TSA to be useful as vaccines for Leishmania major. Recently, the role of interleukin-22 (IL-22) in tissue repair has been demonstrated. In this research, the effect of IL-22 on encoding TSA gene of Leishmania major in BALB/c mice was assessed

Ground Motion Duration Effects on the Seismic Risk Assessment of Wood Light-Frame Buildings

Wood construction comprises a large portion of building stocks of several countries across the globe with high preparedness for earthquakes including Japan, Canada, and the United States. Built environments of these countries are prone to long-duration ground shakings due largely to the proximity of subduction faulting systems. However, the current seismic design requirements do not adequately emphasize this key feature of ground motions. This study evaluates the impact of long-duration ground motions on seismic risk characteristics of code-conforming wood lightframe buildings. To this end, a study matrix of wood light-frame buildings is developed incorporating with two different heights (i.e., 1-story and 4-story) and two distinct occupancies (i.e., multi-family and commercial) designed for a very high seismic region according to the latest pertinent design requirements of the United States. The seismic performance of these buildings is assessed through incremental dynamic analysis (IDA) in accordance with FEMA P-695 recommendations. Each building is analyzed using three sets of ground motions, i.e., far-field FEMA P-695 ground motions ensemble, an ensemble of short-duration ground motions, and an ensemble of long-duration ground motions. For each building, structural responses are obtained, and collapse fragility for these three sets of ground motions are derived. Next, the structural analysis results are relayed to a component-based loss assessment framework developed based on performance-based earthquake engineering principles in order to predict the seismic risk characteristics of the adopted buildings including the vulnerability function, risk curve, and average annual loss (AAL). The loss assessment is conducted separately for the structural and nonstructural components as well as the content of the buildings. The study reveals the considerable effect of ground motion duration on the seismic vulnerability of light-frame wood buildings, specifically in the case of 4-story wood light-frame building which reveals approximately a mean increase of 140.0% in the predicted losses

Properties of contactless and contacted charging in MEMS capacitive switches

The dielectric charging in MEMS capacitive switches is a complex effect. The high electric field during pull-down causes intrinsic free charge migration and dipole orientation as well as charge injection. The macroscopic dipole moment of the first two mechanisms is opposite to the one arising from charge injection. This causes partial compensation hence mitigates the overall charging and increases the device lifetime. The charging due to intrinsic free charge migration and dipole orientation can be monitored under contactless electric field application in the pull-up state. The paper investigates the characteristics of contactless charging and compares them with the ones of contacted charging. The characteristics of the discharging process that follows each charging procedure are also presented

MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1

Background MicroRNA-129-1 (miR-129-1) seems to behave as a tumour suppressor since its decreased expression is associated with different tumours such as glioblastoma multiforme (GBM). GBM is the most common form of brain tumours originating from glial cells. The impact of miR-129-1 downregulation on GBM pathogenesis has yet to be elucidated. Methods MiR-129-1 was overexpressed in GBM cells, and its effect on proliferation was investigated by cell cycle assay. MiR-129-1 predicted targets (CDK6, IGF1, HDAC2, IGF2BP3 and MAPK1) were also evaluated by western blot and luciferase assay. Results Restoration of miR-129-1 reduced cell proliferation and induced G1 accumulation, significantly. Several functional assays confirmed IGF2BP3, MAPK1 and CDK6 as targets of miR-129-1. Despite the fact that IGF1 expression can be suppressed by miR-129-1, through 30-untranslated region complementary sequence, we could not find any association between IGF1 expression and GBM. MiR-129-1 expression inversely correlates with CDK6, IGF2BP3 and MAPK1 in primary clinical samples. Conclusion This is the first study to propose miR129-1 as a negative regulator of IGF2BP3 and MAPK1 and also a cell cycle arrest inducer in GBM cells. Our data suggests miR-129-1 as a potential tumour suppressor and presents a rationale for the use of miR-129-1 as a novel strategy to improve treatment response in GBM

A Probabilistic Casualty Model to Include Injury Severity Levels in Seismic Risk Assessment

Despite the increasing adoption of Performance-Based Earthquake Engineering (PBEE) in seismic risk assessment and design of buildings, earthquakes resulted in around 1.8 million injuries (three times the number of fatalities) over the past two decades. Several existing PBEE-based methodologies use rudimentary models that may not accurately estimate earthquake-induced casualties. Even when models are suitable for predicting the total number of fatalities and critical injuries, they may fail to adequately differentiate between different levels of injury severity. This paper draws attention to the importance of extending the seismic casualty assessment method by broadening the perspective on injury severity. To this cause, a probabilistic model is developed to predict fatalities and injuries due to earthquakes. The proposed model adopts the FEMA P-58 framework for risk assessment and considers six injury severity levels (minor, moderate, serious, severe, critical and fatal), in accordance with the Abbreviated Injury Scale (AIS). The aforementioned framework evaluates the casualty risk with five modules: seismic hazard analysis, structural analysis and response evaluation (using incremental dynamic analysis), building collapse simulation, detailed casualty assessment caused by structural, nonstructural, and content components of the building, and injury severity assessment. The injury severity assessment module assumes two modes of injury: occupants falling on the floor resulting in injury and injuries caused by unstable building contents hitting occupants as a result of sliding or overturning. The framework uses an occupant-time location model to predict the number of injuries and a set of building content fragility curves for sliding and overturning failure modes, developed by the incremental dynamic analyses. The proposed model was applied to a case study of a reinforced concrete, moment-frame office building furnished with 21 different content objects. The results show that the frequency of injuries resulting in hospitalization can be up to 30 times more than that of the fatal injuries at low shaking intensity levels and may amplify by 20 times at high intensity shaking

Numerical prediction of developing flow in gas pipelines

Paper presented at the 5th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, South Africa, 1-4 July, 2007.In this paper the numerical modeling of the dynamic behavior of compressible gas flow is investigated in pipelines. The numerical simulation is performed by solving the coupled conservation form of the governing equations for twodimensional, laminar, viscous, supersonic flow in developing region under different thermal boundary conditions. The numerical procedure is a finite-volume based finite-element method applied on unstructured grids. The convection terms are discretized by well-defined Roe Method and diffusion terms by a Galerkin finite element formulation. The temporal terms are evaluated based on an explicit fourth order Runge-Kutta scheme. The results indicate that heating the gas flow leads to an increase in pressure loss. In the other words, cooling the gas flow leads to decrease the pressure drop or power consumption of booster pressure station. Furthermore, change in the gas viscosity has considerable effects on the flow quantities such as pressure loss and friction factor

A Similarity Solution with Two-Equation Turbulence Model for Computation of Turbulent Film Condensation on a Vertical Surface

In this paper, we presented a similarity solution for turbulent film condensation of stationary vapor on an isothermal vertical flat plate. In this method, some similarity transformations are employed and the set of governing partial differential equations (PDE) of conservation together with transport equations of turbulent kinetic energy and dissipation rate are transformed into a set of ordinary differential equations (ODE). Calculated data for the flow field, velocity profile, wall shear stress, condensate film thickness, turbulent kinetic energy, rate of dissipation, and heat transfer properties are discussed. The effect of Prandtl (Pr) number was also investigated in a wide range of variations. The obtained results showed that at high Prandtl numbers, the velocity profile becomes more uniform across the condensation film and therefore, the kinetic energy of turbulence is reduced. Furthermore, the effect of change in Pr is negligible at high Pr numbers and consequently, the flow parameters have no significant change in this range. The friction coefficient changes linearly through the condensation film and the slope of friction lines diminishes slightly by the Pr number. The rate of turbulent kinetic energy increases linearly from the wall up to about 20% of condensate film, then rises asymptotically and converges to a constant value near the liquid-vapor interface. Also, the rate of turbulent dissipation grows linearly up to 40% of condensate film thickness and then increases slightly while it oscillates

Study of temperature-curvature relationships in Bi-stable composite laminates

The interest in bi-stable structures comes from their ability that these structures can have two different stable equilibrium configurations to define a discrete set of stable shapes. The geometrical changes occur with no need to continuously consume power, and mechanical hinges to preserve the structure in each stable shape. It is known that asymmetric composite laminates can have bi-stable response to different kind of loadings. In this research, the non-linear temperature-curvature relationship for the asymmetric composite laminates is studied using Rayleigh–Ritz technique. Attention is focused on studying the effect of material temperature dependency and resin layers; especially in the bifurcation point by use of analytical method. To this end, the well-known analytical theories are extended and used to consider the temperature dependency of material. The results obtained from the theory are then compared with the finite element simulations results and a good correlation is obtained. Finally, an experimental investigation is carried out and several specimens with [90/0] T, [70/–20]T and [70/20]T compositions were manufactured. In order to study the effect of resin layers, optical microscopy is utilized and the exact thickness of different layers in the manufactured specimens is determined. The thermal responses of the manufactured plates were measured and used to validate the results obtained from the analytical theory and finite element simulations