668 research outputs found
Gas permeation through a polymer network
We study the diffusion of gas molecules through a two-dimensional network of
polymers with the help of Monte Carlo simulations. The polymers are modeled as
non-interacting random walks on the bonds of a two-dimensional square lattice,
while the gas particles occupy the lattice cells. When a particle attempts to
jump to a nearest-neighbor empty cell, it has to overcome an energy barrier
which is determined by the number of polymer segments on the bond separating
the two cells. We investigate the gas current as a function of the mean
segment density , the polymer length and the probability
for hopping across segments. Whereas decreases monotonically with
for fixed , its behavior for fixed and increasing
depends strongly on . For small, non-zero , appears to increase
slowly with . In contrast, for , it is dominated by the underlying
percolation problem and can be non-monotonic. We provide heuristic arguments to
put these interesting phenomena into context.Comment: Dedicated to Lothar Schaefer on the occasion of his 60th birthday. 11
pages, 3 figure
The Effects of Next-Nearest-Neighbor Interactions on the Orientation Dependence of Step Stiffness: Reconciling Theory with Experiment for Cu(001)
Within the solid-on-solid (SOS) approximation, we carry out a calculation of
the orientational dependence of the step stiffness on a square lattice with
nearest and next-nearest neighbor interactions. At low temperature our result
reduces to a simple, transparent expression. The effect of the strongest trio
(three-site, non pairwise) interaction can easily be incorporated by modifying
the interpretation of the two pairwise energies. The work is motivated by a
calculation based on nearest neighbors that underestimates the stiffness by a
factor of 4 in directions away from close-packed directions, and a subsequent
estimate of the stiffness in the two high-symmetry directions alone that
suggested that inclusion of next-nearest-neighbor attractions could fully
explain the discrepancy. As in these earlier papers, the discussion focuses on
Cu(001).Comment: 8 pages, 3 figures, submitted to Phys. Rev.
Distributions of absolute central moments for random walk surfaces
We study periodic Brownian paths, wrapped around the surface of a cylinder.
One characteristic of such a path is its width square, , defined as its
variance. Though the average of over all possible paths is well known,
its full distribution function was investigated only recently. Generalising
to , defined as the -th power of the {\it magnitude} of the
deviations of the path from its mean, we show that the distribution functions
of these also scale and obtain the asymptotic behaviour for both large and
small
Stochastic models in population biology and their deterministic analogs
In this paper we introduce a class of stochastic population models based on
"patch dynamics". The size of the patch may be varied, and this allows one to
quantify the departures of these stochastic models from various mean field
theories, which are generally valid as the patch size becomes very large. These
models may be used to formulate a broad range of biological processes in both
spatial and non-spatial contexts. Here, we concentrate on two-species
competition. We present both a mathematical analysis of the patch model, in
which we derive the precise form of the competition mean field equations (and
their first order corrections in the non-spatial case), and simulation results.
These mean field equations differ, in some important ways, from those which are
normally written down on phenomenological grounds. Our general conclusion is
that mean field theory is more robust for spatial models than for a single
isolated patch. This is due to the dilution of stochastic effects in a spatial
setting resulting from repeated rescue events mediated by inter-patch
diffusion. However, discrete effects due to modest patch sizes lead to striking
deviations from mean field theory even in a spatial setting.Comment: 47 pages, 9 figure
Microfluidic tools for enhanced characterization of therapeutic stem cells and prediction of their potential antimicrobial secretome
Antibiotic resistance is creating enormous attention on the development of new antibiotic-free therapy strategies for bacterial diseases. Mesenchymal stromal stem cells (MSCs) are the most promising candidates in current clinical trials and included in several cell-therapy protocols. Together with the well-known immunomodulatory and regenerative potential of the MSC secretome, these cells have shown direct and indirect anti-bacterial effects. However, the low reproducibility and standardization of MSCs from different sources are the current limitations prior to the purification of cell-free secreted antimicrobial peptides and exosomes. In order to improve MSC characterization, novel label-free functional tests, evaluating the biophysical properties of the cells, will be advan-tageous for their cell profiling, population sorting, and quality control. We discuss the potential of emerging microfluidic technologies providing new insights into density, shape, and size of live cells, starting from heterogeneous or 3D cultured samples. The prospective application of these technologies to studying MSC populations may contribute to developing new biopharmaceutical strategies with a view to naturally overcoming bacterial defense mechanisms
Enhanced detection techniques of orbital angular momentum states in the classical and quantum regimes
The orbital angular momentum (OAM) of light has been at the center of several classical and quantum applications for imaging, information processing and communication. However, the complex structure inherent in OAM states makes their detection and classification nontrivial in many circumstances. Most of the current detection schemes are based on models of the OAM states built upon the use of Laguerre-Gauss (LG) modes. However, this may not in general be sufficient to capture full information on the generated states. In this paper, we go beyond the LG assumption, and employ hypergeometric-Gaussian (HyGG) modes as the basis states of a refined model that can be used - in certain scenarios - to better tailor OAM detection techniques. We show that enhanced performances in OAM detection are obtained for holographic projection via spatial light modulators in combination with single-mode fibers (SMFs), and for classification techniques based on a machine learning approach. Furthermore, a three-fold enhancement in the SMF coupling efficiency is obtained for the holographic technique, when using the HyGG model with respect to the LG one. This improvement provides a significant boost in the overall efficiency of OAM-encoded single-photon detection systems. Given that most of the experimental works using OAM states are effectively based on the generation of HyGG modes, our findings thus represent a relevant addition to experimental toolboxes for OAM-based protocols in quantum communication, cryptography and simulation
Complete Solution of the Kinetics in a Far-from-equilibrium Ising Chain
The one-dimensional Ising model is easily generalized to a \textit{genuinely
nonequilibrium} system by coupling alternating spins to two thermal baths at
different temperatures. Here, we investigate the full time dependence of this
system. In particular, we obtain the evolution of the magnetisation, starting
with arbitrary initial conditions. For slightly less general initial
conditions, we compute the time dependence of all correlation functions, and
so, the probability distribution. Novel properties, such as oscillatory decays
into the steady state, are presented. Finally, we comment on the relationship
to a reaction-diffusion model with pair annihilation and creation.Comment: Submitted to J. Phys. A (Letter to the editor
A new predictive technology for perinatal stem cell isolation suited for cell therapy approaches
The use of stem cells for regenerative applications and immunomodulatory effect is in-creasing. Amniotic epithelial cells (AECs) possess embryonic‐like proliferation ability and multipo-tent differentiation potential. Despite the simple isolation procedure, inter‐individual variability and different isolation steps can cause differences in isolation yield and cell proliferation ability, compromising reproducibility observations among centers and further applications. We investi-gated the use of a new technology as a diagnostic tool for quality control on stem cell isolation. The instrument label‐free separates cells based on their physical characteristics and, thanks to a micro-camera, generates a live fractogram, the fingerprint of the sample. Eight amniotic membranes were processed by trypsin enzymatic treatment and immediately analysed. Two types of profile were generated: a monomodal and a bimodal curve. The first one represented the unsuccessful isolation with all recovered cell not attaching to the plate; while for the second type, the isolation process was successful, but we discovered that only cells in the second peak were alive and resulted adherent. We optimized a Quality Control (QC) method to define the success of AEC isolation using the frac-togram generated. This predictive outcome is an interesting tool for laboratories and cell banks that isolate and cryopreserve fetal annex stem cells for research and future clinical applications
Entropy production and fluctuation relations for a KPZ interface
We study entropy production and fluctuation relations in the restricted
solid-on-solid growth model, which is a microscopic realization of the KPZ
equation. Solving the one dimensional model exactly on a particular line of the
phase diagram we demonstrate that entropy production quantifies the distance
from equilibrium. Moreover, as an example of a physically relevant current
different from the entropy, we study the symmetry of the large deviation
function associated with the interface height. In a special case of a system of
length L=4 we find that the probability distribution of the variation of height
has a symmetric large deviation function, displaying a symmetry different from
the Gallavotti-Cohen symmetry.Comment: 21 pages, 5 figure
Some Exact Results for the Exclusion Process
The asymmetric simple exclusion process (ASEP) is a paradigm for
non-equilibrium physics that appears as a building block to model various
low-dimensional transport phenomena, ranging from intracellular traffic to
quantum dots. We review some recent results obtained for the system on a
periodic ring by using the Bethe Ansatz. We show that this method allows to
derive analytically many properties of the dynamics of the model such as the
spectral gap and the generating function of the current. We also discuss the
solution of a generalized exclusion process with -species of particles and
explain how a geometric construction inspired from queuing theory sheds light
on the Matrix Product Representation technique that has been very fruitful to
derive exact results for the ASEP.Comment: 21 pages; Proceedings of STATPHYS24 (Cairns, Australia, July 2010
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