Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives

Brønsted acid catalyzed tandem cyclization was found to be highly effective for the preparation of a series of polysubstituted 4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone derivatives were also selectively synthesized by employing NIS and/or Brønsted acid. NIS as an electrophilic reagent could promote these reactions efficiently and rapidly under very mild reaction conditions

Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives

Brønsted acid catalyzed tandem cyclization was found to be highly effective for the preparation of a series of polysubstituted 4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone derivatives were also selectively synthesized by employing NIS and/or Brønsted acid. NIS as an electrophilic reagent could promote these reactions efficiently and rapidly under very mild reaction conditions

Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives

Brønsted acid catalyzed tandem cyclization was found to be highly effective for the preparation of a series of polysubstituted 4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone derivatives were also selectively synthesized by employing NIS and/or Brønsted acid. NIS as an electrophilic reagent could promote these reactions efficiently and rapidly under very mild reaction conditions

Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives

Brønsted acid catalyzed tandem cyclization was found to be highly effective for the preparation of a series of polysubstituted 4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone derivatives were also selectively synthesized by employing NIS and/or Brønsted acid. NIS as an electrophilic reagent could promote these reactions efficiently and rapidly under very mild reaction conditions

TMSCl-Mediated Synthesis of α,β-Unsaturated Amides via C–C Bond Cleavage and C–N Bond Formation of Propargyl Alcohols with Trimethylsilyl Azide

A new method with high efficiency for the synthesis of α,β-unsaturated amides from the easily prepared propargyl alcohols and TMSN₃ using TMSCl as an acid promoter is developed. A wide variety of α,β-unsaturated amides were produced in moderate to excellent yields. Mechanistic studies indicate that this transformation involves TMSCl-mediated allenylazide intermediate formation, C–C bond cleavage, and C–N bond formation. Significantly, this reaction shows good functional group compatibility and high regioselectivity, with a relatively short reaction time and inexpensive reagents

Correction to “Facile Synthesis of Halogenated Spiroketals via a Tandem Iodocyclization”

Correction to “Facile Synthesis of Halogenated Spiroketals via a Tandem Iodocyclization

Palladium-Catalyzed/Norbornene-Mediated <i>ortho</i>-Amination/<i>N</i>‑Tosylhydrazone Insertion Reaction: An Approach to the Synthesis of <i>ortho</i>-Aminated Vinylarenes

<i>ortho</i>-Aminated vinylarene derivatives were obtained via a reaction of aryl iodides, <i>N</i>-benzoyloxyamines, and <i>N</i>-tosylhydrazones. This approach involves a palladium-catalyzed, norbornene-mediated <i>ortho</i>-amination/<i>N</i>-tosylhydrazone insertion reaction. In this transformation, one C–N bond and one C–C bond are formed and an amine group is introduced at the <i>ortho</i> position successfully