Brønsted Acid Catalyzed
and NIS-Promoted Cyclization
of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone,
and 3‑Pyrrolone Derivatives
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Abstract
Brønsted
acid catalyzed tandem cyclization was found to be
highly effective for the preparation of a series of polysubstituted
4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone
derivatives were also selectively synthesized by employing NIS and/or
Brønsted acid. NIS as an electrophilic reagent could promote
these reactions efficiently and rapidly under very mild reaction conditions