Research on application of patch near-field acoustic holography using acoustic radiation modes with double layers

To solve the problems of near-field acoustic holography in actual applications, research based on acoustic radiation modes with double layers is studied in this paper. The sound pressure model by using acoustic radiation modes is selected to express the sound field firstly. Then, the sound field separation with double pressure measurement layers has been applied to remove the interference from the opposite direction. Thirdly, the method based on data interpolation and extrapolation is put forward to increase the holographic value equivalently, the results of which are closer to the actual measured value obtained by more measuring points. Numerical simulations based on the theoretical description are conducted to demonstrate the validity of the proposed method, and experiments for a boundary constraint steel plate and a loudspeaker are performed to demonstrate its feasibility

Sound field separation technique using the principle of double layer patch acoustic radiation modes

In order to solve the problems of near-field acoustic holography in applications such as external interference and aperture effects, a sound field separation technique using the principle of double layer patch acoustic radiation modes is proposed in this paper. The radiated acoustic pressures over two planar surfaces at certain distances from the sources are calculated first. Then, the effects resulting from the backscattering interference in non-free sound fields can be eliminated by a double-layer sound field separation technique. Next, data interpolation and extrapolation are performed on the separated data to increase the sound source's pressures on the holographic plane equivalently for holographic images with higher spatial resolution. Simulation and experimental results demonstrate that good agreements can be obtained with few measuring points

The emerging role of deubiquitylating enzymes as therapeutic targets in cancer metabolism.

Cancer cells must rewire cellular metabolism to satisfy the unbridled proliferation, and metabolic reprogramming provides not only the advantage for cancer cell proliferation but also new targets for cancer treatment. However, the plasticity of the metabolic pathways makes them very difficult to target. Deubiquitylating enzymes (DUBs) are proteases that cleave ubiquitin from the substrate proteins and process ubiquitin precursors. While the molecular mechanisms are not fully understood, many DUBs have been shown to be involved in tumorigenesis and progression via controlling the dysregulated cancer metabolism, and consequently recognized as potential drug targets for cancer treatment. In this article, we summarized the significant progress in understanding the key roles of DUBs in cancer cell metabolic rewiring and the opportunities for the application of DUBs inhibitors in cancer treatment, intending to provide potential implications for both research purpose and clinical applications

Sound field separation technique using the principle of double layer patch acoustic radiation modes

In order to solve the problems of near-field acoustic holography in applications such as external interference and aperture effects, a sound field separation technique using the principle of double layer patch acoustic radiation modes is proposed in this paper. The radiated acoustic pressures over two planar surfaces at certain distances from the sources are calculated first. Then, the effects resulting from the backscattering interference in non-free sound fields can be eliminated by a double-layer sound field separation technique. Next, data interpolation and extrapolation are performed on the separated data to increase the sound source's pressures on the holographic plane equivalently for holographic images with higher spatial resolution. Simulation and experimental results demonstrate that good agreements can be obtained with few measuring points

tree-based service discovery in mobile ad hoc networks

Institute of Electrical and Electronics Engineers; IEEE Computer Society; IEEE Comput. Soc. Tech. Comm. Serv. Comput. (TCSC); Natural Science Foundation of China; Hangzhou Dianzi UniversityUtilizing service oriented architectures to enhance seamless collaborations and information sharing among nodes in mobile ad hoc networks with limited communication capability is a challenging task. In this paper a novel tree-based service discovery mechanism, able to achieve high accuracy in the process of service discovery, is proposed, which affords wireless communication overheads nearly linear with the number of property-changing services offered by the whole network. The mechanism is suitable and customized for typical mobile networks. As properties such as quality and capability of the aimed services are always changing rather than remaining invariable, a service matching process is also provided, where an efficient method is implemented for searching for a target service in a local service repository with given conditions and policies

Key role of Nb5+ in achieving water-resistant red emission in K2Ta1-xNbxF7:Mn4+ phosphors

Mn4+-activated fluoride is one of the most important red phosphors for white light-emitting diodes (WLEDs) with high color rendering index (CRI). Due to a lack of water resistance, their potential applications are limited. Although surface coating strategies improve the waterproof stability of fluoride red phosphors, they have downsides. It was found that Nb5+ plays an important role in improving the water resistance of Mn4+-activated oxyfluorides by preventing the hydrolysis of [MnF6]2-. In this work, the influence of Nb5+ on the waterproof stability of Mn4+-activated fluorides was explored. A set of synthesized K2Ta1-xNbxF7:Mn4+ phosphors exhibit tunable and superior water resistance. The photoluminescence (PL) intensity of the representative sample K2Ta0.6Nb0.4F7:5%Mn4+ remains nearly 100% of its initial value even after being immersed in water for 60 min, which is significantly higher than the commercial K2SiF6:Mn4+ red phosphor (8.7%). Our findings open up new possibilities for the development of waterproof fluoride red phosphors. © 2023 Elsevier Ltd and Techna Group S.r.l

Histone demethylases UTX and JMJD3 are required for NKT cell development in mice

Abstract Background Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties. The role of histone modifying enzymes in conventional T cell development has been extensively studied, little is known about the function of enzymes regulating histone methylation in NKT cells. Results We show that conditional deletion of histone demethylases UTX and JMJD3 by CD4-Cre leads to near complete loss of liver NKT cells, while conventional T cells are less affected. Loss of NKT cells is cell intrinsic and not due to an insufficient selection environment. The absence of NKT cells in UTX/JMJD3-deficient mice protects mice from concanavalin A‐induced liver injury, a model of NKT‐mediated hepatitis. GO‐analysis of RNA-seq data indicates that cell cycle genes are downregulated in UTX/JMJD3-deleted NKT progenitors, and suggest that failed expansion may account for some of the cellular deficiency. The phenotype appears to be demethylase‐dependent, because UTY, a homolog of UTX that lacks catalytic function, is not sufficient to restore their development and removal of H3K27me3 by deletion of EZH2 partially rescues the defect. Conclusions NKT cell development and gene expression is sensitive to proper regulation of H3K27 methylation. The H3K27me3 demethylase enzymes, in particular UTX, promote NKT cell development, and are required for effective NKT function

Global gene expression profiling identifies ALDH2, CCNE1 and SMAD3 as potential prognostic markers in upper tract urothelial carcinoma

Background: Current knowledge about the molecular properties and prognostic markers of upper tract urothelial carcinoma (UTUC) is sparse and often based on bladder urothelial carcinoma (UC), which is thought to share common risk factors with UTUC. However, studies have suggested that differences exist regarding tumor behavior and molecular biology of these cancers, comprehensive investigations are needed to guide the clinical management of UTUC. In recent years, massively parallel sequencing has allowed insights into the biology of many cancers, and molecular prognostic markers based on this approach are rapidly emerging. The goal of this study was to characterize the gene expression patterns of UTUC using massively parallel sequencing, and identify potential molecular markers for prognosis in patients with UTUC. Methods: We compared the genome-wide mRNA expression profile of cancer and matched normal tissues from 10 patients with UTUC to identify significantly deregulated genes. We also examined the protein levels of prognostic marker candidates in 103 patients with UTUC, and tested the association of these markers with overall survival using Kaplan-Meier model and Cox regression. Results: Functional enrichment of significantly deregulated genes revealed that expression patterns of UTUC were characterized by disorders of cell proliferation and metabolism. And we also compared the expression profile of UTUC with that of bladder UC. Our results highlighted both shared (e.g. disorders of cell cycling and growth signal transduction) and tumor-specific (e.g. abnormal metabolism in UTUC and disruptions of adhesion pathways in bladder UC) features of these two cancers. Importantly, we identified that low protein expression of ALDH2 while high CCNE1 and SMAD3 were significantly associated with increased depth ({*}P < 0.05) and lower overall survival ({*}{*}{*}P < 0.0001) in an independent set of 103 patients. Multivariate Cox regression revealed that all these three genes were independent prognostic indicators in patients with UTUC ({*}{*}{*}P < 0.001). Conclusions: In conclusion, our study characterized the comprehensive expression profile of UTUC and highlighted both commons and differences in expression patterns between UTUC and bladder UC. And we, for the first time, revealed that ALDH2, CCNE1 and SMAD3 are associated with prognosis in patients with UTUC