Exploring the Role of Purpose in the Lives of Career Changers: A Qualitative Inquiry

Although purpose in life is well-established as a key element of optimal human functioning, there is a lack of qualitative research exploring the role of purpose in individuals’ lives, particularly in the context of career change. The aim of the study is to gain a deep understanding of the role of purpose in the lives of career changers, including the process of developing purpose and its impact on individuals’ well-being. A qualitative method was employed that involved semi-structured interviews with a sample of thirteen participants who went through a career change process. The qualitative grounded theory analysis reveals a purpose process model, which posits that individuals experience purpose as an ongoing and dynamic process consisting of questioning, exploring, unfolding, and evolving as critical developmental stages of individuals’ journeys to discover and develop purpose. The process of pursuing a purposeful way of living generally has a positive impact on individuals’ hedonic and eudaemonic well-being but can also have its “dark side” that may detract from life. Practical implications for career counseling, as well as future direction of research are discussed

Exploring the role of purpose in the lives of career changers: A qualitative inquiry

Although purpose in life is well-established as a key element of optimal human functioning, there is a lack of qualitative research exploring the role of purpose in individuals’ lives, particularly in the context of career change. The aim of the study is to gain a deep understanding of the role of purpose in the lives of career changers, including the process of developing purpose and its impact on individuals’ well-being.  A qualitative method was employed that involved semi-structured interviews with a sample of thirteen participants who went through a career change process. The qualitative grounded theory analysis reveals a purpose process model, which posits that individuals experience purpose as an ongoing and dynamic process consisting of questioning, exploring, unfolding, and evolving as critical developmental stages of individuals’ journeys to discover and develop purpose. The process of pursuing a purposeful way of living generally has a positive impact on individuals’ hedonic and eudaemonic well-being but can also have its “dark side” that may detract from life. Practical implications for career counseling, as well as future direction of research are discussed

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Exploring the Role of Purpose in the Lives of Career Changers: A Qualitative Inquiry

Although purpose in life is well-established as a key element of optimal human functioning, there is a lack of qualitative research exploring the role of purpose in individuals’ lives, particularly in the context of career change. The aim of the study is to gain a deep understanding of the role of purpose in the lives of career changers, including the process of developing purpose and its impact on individuals’ well-being. A qualitative method was employed that involved semi-structured interviews with a sample of thirteen participants who went through a career change process. The qualitative grounded theory analysis reveals a purpose process model, which posits that individuals experience purpose as an ongoing and dynamic process consisting of questioning, exploring, unfolding, and evolving as critical developmental stages of individuals’ journeys to discover and develop purpose. The process of pursuing a purposeful way of living generally has a positive impact on individuals’ hedonic and eudaemonic well-being but can also have its “dark side” that may detract from life. Practical implications for career counseling, as well as future direction of research are discussed

Cómo prevenir la indisciplina : programa de intervención educativa

El Programa de Prevención de las Conductas Disruptivas (PPCD) tiene por objeto la prevención y superación de problemas conductuales de los alumnos, como son: la desobediencia, el oposicionismo, la hiperactividad, la agresividad, etc., que alteran la dinámica del aula. Así como los comportamientos inatentivos que dispersan la atención y el interés por las actividades curriculares. De este modo, se pretende la formación de conductas y el fomento de actitudes y hábitos ajustados a las necesidades escolares, familiares y sociales; que el niño analice y prevea las consecuencias de sus acciones y llegue a interiorizar las normas de convivencia y disciplina. Implica tanto al alumno susceptible de tales problemas como a sus profesores y a sus familias.MadridBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

CEPC Conceptual Design Report: Volume 2 - Physics & Detector

The Circular Electron Positron Collider (CEPC) is a large international scientific facility proposed by the Chinese particle physics community to explore the Higgs boson and provide critical tests of the underlying fundamental physics principles of the Standard Model that might reveal new physics. The CEPC, to be hosted in China in a circular underground tunnel of approximately 100 km in circumference, is designed to operate as a Higgs factory producing electron-positron collisions with a center-of-mass energy of 240 GeV. The collider will also operate at around 91.2 GeV, as a Z factory, and at the WW production threshold (around 160 GeV). The CEPC will produce close to one trillion Z bosons, 100 million W bosons and over one million Higgs bosons. The vast amount of bottom quarks, charm quarks and tau-leptons produced in the decays of the Z bosons also makes the CEPC an effective B-factory and tau-charm factory. The CEPC will have two interaction points where two large detectors will be located. This document is the second volume of the CEPC Conceptual Design Report (CDR). It presents the physics case for the CEPC, describes conceptual designs of possible detectors and their technological options, highlights the expected detector and physics performance, and discusses future plans for detector R&D and physics investigations. The final CEPC detectors will be proposed and built by international collaborations but they are likely to be composed of the detector technologies included in the conceptual designs described in this document. A separate volume, Volume I, recently released, describes the design of the CEPC accelerator complex, its associated civil engineering, and strategic alternative scenarios

CEPC Conceptual Design Report: Volume 2 - Physics & Detector

The Circular Electron Positron Collider (CEPC) is a large international scientific facility proposed by the Chinese particle physics community to explore the Higgs boson and provide critical tests of the underlying fundamental physics principles of the Standard Model that might reveal new physics. The CEPC, to be hosted in China in a circular underground tunnel of approximately 100 km in circumference, is designed to operate as a Higgs factory producing electron-positron collisions with a center-of-mass energy of 240 GeV. The collider will also operate at around 91.2 GeV, as a Z factory, and at the WW production threshold (around 160 GeV). The CEPC will produce close to one trillion Z bosons, 100 million W bosons and over one million Higgs bosons. The vast amount of bottom quarks, charm quarks and tau-leptons produced in the decays of the Z bosons also makes the CEPC an effective B-factory and tau-charm factory. The CEPC will have two interaction points where two large detectors will be located. This document is the second volume of the CEPC Conceptual Design Report (CDR). It presents the physics case for the CEPC, describes conceptual designs of possible detectors and their technological options, highlights the expected detector and physics performance, and discusses future plans for detector R&D and physics investigations. The final CEPC detectors will be proposed and built by international collaborations but they are likely to be composed of the detector technologies included in the conceptual designs described in this document. A separate volume, Volume I, recently released, describes the design of the CEPC accelerator complex, its associated civil engineering, and strategic alternative scenarios

CEPC Conceptual Design Report: Volume 2 - Physics & Detector

The Circular Electron Positron Collider (CEPC) is a large international scientific facility proposed by the Chinese particle physics community to explore the Higgs boson and provide critical tests of the underlying fundamental physics principles of the Standard Model that might reveal new physics. The CEPC, to be hosted in China in a circular underground tunnel of approximately 100 km in circumference, is designed to operate as a Higgs factory producing electron-positron collisions with a center-of-mass energy of 240 GeV. The collider will also operate at around 91.2 GeV, as a Z factory, and at the WW production threshold (around 160 GeV). The CEPC will produce close to one trillion Z bosons, 100 million W bosons and over one million Higgs bosons. The vast amount of bottom quarks, charm quarks and tau-leptons produced in the decays of the Z bosons also makes the CEPC an effective B-factory and tau-charm factory. The CEPC will have two interaction points where two large detectors will be located. This document is the second volume of the CEPC Conceptual Design Report (CDR). It presents the physics case for the CEPC, describes conceptual designs of possible detectors and their technological options, highlights the expected detector and physics performance, and discusses future plans for detector R&D and physics investigations. The final CEPC detectors will be proposed and built by international collaborations but they are likely to be composed of the detector technologies included in the conceptual designs described in this document. A separate volume, Volume I, recently released, describes the design of the CEPC accelerator complex, its associated civil engineering, and strategic alternative scenarios

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

© 2020, The Author(s). The availability of high-quality RNA-sequencing and genotyping data of post-mortem brain collections from consortia such as CommonMind Consortium (CMC) and the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) Consortium enable the generation of a large-scale brain cis-eQTL meta-analysis. Here we generate cerebral cortical eQTL from 1433 samples available from four cohorts (identifying >4.1 million significant eQTL for >18,000 genes), as well as cerebellar eQTL from 261 samples (identifying 874,836 significant eQTL for >10,000 genes). We find substantially improved power in the meta-analysis over individual cohort analyses, particularly in comparison to the Genotype-Tissue Expression (GTEx) Project eQTL. Additionally, we observed differences in eQTL patterns between cerebral and cerebellar brain regions. We provide these brain eQTL as a resource for use by the research community. As a proof of principle for their utility, we apply a colocalization analysis to identify genes underlying the GWAS association peaks for schizophrenia and identify a potentially novel gene colocalization with lncRNA RP11-677M14.2 (posterior probability of colocalization 0.975)