Assessing the Impacts of Urbanization on Albedo in Jing-Jin-Ji Region of China

As an indicative parameter that represents the ability of the Earth’s surface to reflect solar radiation, albedo determines the allocation of solar energy between the Earth’s surface and the atmosphere, which plays an important role in both global and local climate change. Urbanization is a complicated progress that greatly affects urban albedo via land cover change, human heat, aerosol, and other human activities. Although many studies have been conducted to identify the effects of these various factors on albedo separately, there are few studies that have quantitatively determined the combined effects of urbanization on albedo. In this study, based on a partial derivative method, vegetation index data and nighttime light data were used to quantitatively calculate the natural climate change and human activities’ contributions to albedo variations in the Jing-Jin-Ji region, during its highest population growth period from 2001 to 2011. The results show that (1) 2005 is the year when urbanization starts accelerating in the Jing-Jin-Ji region; (2) albedo trends are equal to 0.0065 year−1 before urbanization and 0.0012 year−1 after urbanization, which is a reduction of 4/5; and (3) the contribution rate of urbanization increases from 15% to 48.4%, which leads to a decrease in albedo of approximately 0.05. Understanding the contribution of urbanization to variations in urban albedo is significant for future studies on urban climate change via energy balance and can provide scientific data for energy conservation policymaking

Porcine IFI16 Negatively Regulates cGAS Signaling Through the Restriction of DNA Binding and Stimulation

The innate immunity DNA sensors have drawn much attention due to their significant importance against the infections with DNA viruses and intracellular bacteria. Among the multiple DNA sensors, IFI16, and cGAS are the two major ones, subjected to extensive studies. However, these two DNA sensors in livestock animals have not been well defined. Here, we studied the porcine IFI16 and cGAS, and their mutual relationship. We found that both enable STING-dependent signaling to downstream IFN upon DNA transfection and HSV-1 infection, and cGAS plays a major role in DNA signaling. In terms of their relationship, IFI16 appeared to interfere with cGAS signaling as deduced from both transfected and knockout cells. Mechanistically, IFI16 competitively binds with agonist DNA and signaling adaptor STING and thereby influences second messenger cGAMP production and downstream gene transcription. Furthermore, the HIN2 domain of porcine IFI16 harbored most of its activity and mediated cGAS inhibition. Thus, this study provides a unique insight into the porcine DNA sensing system