Investigation on Social Anxiety of Secondary Vocational Students

Objective: To investigate the status quo of social anxiety among secondary vocational students and the differences in demographic variables through the Communication Anxiety Scale (IAS) survey. Methods: A total of 890 students from a secondary vocational school in Changshou District of Chongqing were surveyed with the Communication Anxiety Scale (IAS) to understand the social anxiety of secondary vocational students. Results: The mean score of social anxiety of secondary vocational students was 45.25±9.32. The gender difference of social anxiety in secondary vocational students was significant (P0.05); The social anxiety of secondary vocational students was significantly different in household registration type (P0.05). The difference of social anxiety in family income of secondary vocational students was very significant (P<0.001). Conclusion: The level of social anxiety of secondary vocational students is above the middle level. From the perspective of gender variables, there is a significant difference in the level of social anxiety between male and female students, and the level of social anxiety of male students is significantly lower than that of female students. In terms of grade variables, there was no significant difference in social anxiety in grade variables. From the perspective of the variable of residence type, social anxiety is significantly different between rural students and urban students. The level of social anxiety of rural students is higher than that of urban students. There is no significant difference between only-child and non-only-child in social anxiety. From the perspective of family income level, social anxiety is significantly different among different income families. Students from families with wages higher than the average social level had the lowest level of social anxiety, students from families with wages comparable to the average social level had higher levels of social anxiety, and students from families with wages lower than the average social level had the highest level of social anxiety.

Prediction of musculoskeletal pain after the first intravenous zoledronic acid injection in patients with primary osteoporosis: development and evaluation of a new nomogram

Abstract Objective To construct a new prediction nomogram to predict the risk of musculoskeletal pain in patients with primary osteoporosis who receive zoledronic acid intravenously for the first time. Method Clinical data of 368 patients with primary osteoporosis who received the first intravenous injection of zoledronic acid in our hospital from December 2019 to December 2022 were studied. Patients were divided into a musculoskeletal pain group (n = 258) and a non-musculoskeletal pain group (n = 110) based on the presence or absence of musculoskeletal pain 3 days after injection. Statistically significant predictors were screened by logistic regression analysis and the minimum absolute contraction and selection operator (LASSO) to construct a nomogram. The nomogram was evaluated by the receiver operating characteristic (ROC) curve, the calibration curve, the C-index, and the decision curve analysis (DCA) and verified in a validation cohort. Results The independent predictors of the nomogram were age, serum 25-hydroxyvitamin D, NSAIDs, prior Vitamin D intake, and BMI. The area under the ROC curve (AUC) was 0.980 (95% CI, 0.915–0.987), showing excellent predictive performance. The nomogram c index was 0.980, and the nomogram c index for internal verification remained high at 0.979. Moreover, calibration curves show that the nomogram has good consistency. Finally, the DCA showed that the net benefit of the nomogram was 0.20–0.49. Conclusion Musculoskeletal pain is a common symptom of APR in OP patients treated with intravenous zoledronic acid. Risk factors for musculoskeletal pain after zoledronic acid injection in OP patients were: non-use of NSAIDs, youth (<80 years old), serum 25 (OH) D<30ng /mL, no prior intake of vitamin D, BMI<24 kg /m2. A nomogram constructed from the above predictors can be used to predict musculoskeletal pain after the first zoledronic acid injection

Antiosteoporotic effects of Alpinia officinarum Hance through stimulation of osteoblasts associated with antioxidant effects

Background/Objective: Alpinia officinarum Hance (AOH) is a traditional herbal medicine specific to south China and serves as a civil medication application of an antioxidant. Growing evidence demonstrates that antioxidants are beneficial for the treatment of osteoporosis. This study was designed to investigate the antiosteoporotic effects of total extracts from AOH in ovariectomised (OVX) rats and the different fractions in AOH on primary osteoblasts activities. Methods: The total extract of AOH was extracted by refluxing using 95% ethanol, then the five fractions (F1–F5) were separated from AOH using thin-layer chromatography according to polarity from high to low, and the galangin content was determined using high performance liquid chromatography. In an in vivo study, 36 4-month-old female Sprague-Dawley rats were used as a Sham-operated group, OVX with vehicle (OVX), OVX with epimedium flavonoids (EF, 150 mg/kg/d), and OVX with AOH (AOH, 300 mg/kg/d), respectively. Daily oral administration started on Day 3 after OVX and lasted for 12 weeks. In the in vitro study, primary osteoblasts were incubated with AOH, galangin, and five different fractions (F1–F5) with or without hydrogen peroxide (H2O2), respectively. Results: Treatment with AOH significantly attenuated osteopenia accompanied by a decreased percentage of osteoclast perimeter and bone formation rate per unit of bone surface, enhanced the bone strength, and prevented the deterioration of trabecular microarchitecture associated with a decrease in biochemical parameters of oxidative stress. Furthermore, treatment with AOH, F3, F4, and galangin increased cell viability, differentiation, and mineralisation in osteoblasts with or without H2O2 and rescued the deleterious effects of H2O2 on cell apoptosis and intracellular reactive oxygen species level. The effects on osteoblast formation were highly aligned with the amounts of flavonoids within AOH. Conclusion: These data demonstrate that ethanol extracts from AOH significantly reverse bone loss, partially by increasing bone formation, and by suppressing bone resorption associated with antioxidant effects, suggesting that AOH can be developed as a promising agent for the prevention and treatment of osteoporosis