The origin of summer monsoon rainfall at New Delhi by deuterium excess

International audienceThe deuterium excess in summer monsoon precipitation, determined from isotopic measurements(?18O and Keywords: deuterium excess, relative humidity, origin of precipitatio

Совершенствование маркетинговой деятельности промышленного предприятия (на примере РУП «Белоруснефть-Особино»)

We report a detailed computational and experimental study of the interaction of single-walled carbon nanotubes (SWCNTs) with the drug-metabolizing cytochrome P450 enzyme, CYP3A4. Dose-dependent inhibition of CYP3A4-mediated conversion of the model compound, testosterone, to its major metabolite, 6β-hydroxy testosterone was noted. Evidence for a direct interaction between SWCNTs and CYP3A4 was also provided. The inhibition of enzyme activity was alleviated when SWCNTs were pre-coated with bovine serum albumin. Furthermore, covalent functionalization of SWCNTs with polyethylene glycol (PEG) chains mitigated the inhibition of CYP3A4 enzymatic activity. Molecular dynamics simulations suggested that inhibition of the catalytic activity of CYP3A4 is mainly due to blocking of the exit channel for substrates/products through a complex binding mechanism. This work suggests that SWCNTs could interfere with metabolism of drugs and other xenobiotics and provides a molecular mechanism for this toxicity. Our study also suggests means to reduce this toxicity, eg., by surface modification

Estimation of Carbon Emissions of Domestic Energy Usage by Chinese Residents Based on Input - Output Method

This paper will be based on the existing literature and research methods, with the 1980 to 2014 China’s residential carbon emissions estimates. This paper mainly examines the changes in total residential carbon emissions and per capita carbon emissions, energy consumption per unit of household energy consumption, carbon emissions and energy composition of the above-mentioned analysis of urban and rural compared with the international comparison

Gaseous Pollutent Source Term Estimation Based on Adjoint Probability and Regularization Method

Fast and accurate identification of source locations and release rates is particularly important for improving indoor air quality and ensuring the safety and health of people. Existing methods based on adjoint probability are difficult to distinguish the release rate of dynamic sources, and optimization algorithms based on regularization are limited to analysing only a small amount of potential pollutant source information. Therefore, this study proposed an algorithm combining adjoint equations and regularization models to identify the location and release intensity of pollutant sources in the entire computational domain of a room. Based on the validated indoor CFD computational model, we first obtained a series of response matrices corresponding to the sensor position by solving the adjoint equation, and then used the regularization method and Bayesian inference to extrapolate the release rate and location of dynamic pollutant source in the room. The results shown that the proposed algorithm is convenient and feasible to identify the location and intensity of the indoor pollutant source. Compared with the real source intensity, the identification of constant source intensity is lower than the error threshold (10%) in 97.4% of the time nodes, and the identification of periodic source is lower than the error threshold (10%) in 95.4% of the time nodes. This research provides a new method and perspective for the estimation of indoor pollutant source information

Fixed-Time Adaptive Event-Triggered Guaranteed Performance Tracking Control of Nonholonomic Mobile Robots under Asymmetric State Constraints

A fixed-time adaptive guaranteed performance tracking control is investigated for a category of nonholonomic mobile robots (NMRs) under asymmetric state constraints. For the sake of favorable transient and steady-state properties of the system, a prescribed performance function (PPF) is introduced and a transform function is further constructed. Based on the backstepping technique, an asymmetric barrier Lyapunov function is formulated to ensure the tracking errors converge within a human-specified time. On the foundation of this, the occupation of communication channel is effectively reduced by assigning an event-triggered mechanism (ETM) with relative threshold to the process of controller design. By utilizing the proposed control strategy, the NMR is capable of implementing the enemy dislodging mission while the enemy can always be caught by the NMR and the collision would never be presented. Finally, two simulation experiments are given to verify the effectiveness of the proposed scheme

Hyperbolic Harmonic Mapping for Constrained Brain Surface Registration

Automatic computation of surface correspondence via harmonic map is an active research field in computer vision, computer graphics and computational geometry. It may help document and understand physical and biological phenomena and also has broad applications in biometrics, medical imaging and motion capture. Although numerous studies have been devoted to harmonic map research, limited progress has been made to compute a diffeomorphic harmonic map on general topology surfaces with landmark constraints. This work conquer this problem by changing the Riemannian metric on the target surface to a hyperbolic metric, so that the harmonic mapping is guaranteed to be a diffeomorphism under landmark constraints. The computational algorithms are based on the Ricci flow method and the method is general and robust. We apply our algorithm to study constrained human brain surface registration problem. Experimental results demonstrate that, by changing the Riemannian metric, the registrations are always diffeomorphic, and achieve relative high performance when evaluated with some popular cortical surface registration evaluation standards. 1

Refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy

Abstract Background Anti-mitochondrial antibody (AMA)-positive inflammatory myopathy, a rare type of idiopathic inflammatory myopathy which was frequently difficult to diagnose, can affect muscles and the structure and electrical conduction of the heart. Early identification and treatment of this myopathy can prevent serious cardiovascular adverse events and improve cardiac function. Case presentation We report a patient who experienced repeated syncope, ventricular tachycardia (VT) and heart failure accompanied by weakness and muscle atrophy. He was initially diagnosed with dilated cardiomyopathy and received implantable cardioverter-defibrillator therapy. He was subsequently misdiagnosed as muscular dystrophy due to progressive muscular atrophy. However, the patient developed repeated and refractory VT storms that were not alleviated by conventional therapy. Finally, he was diagnosed with AMA-positive inflammatory myopathy with cardiac injuries. The patient was markedly recovered by being treated with immunosuppressive and immunomodulatory therapy. Conclusion AMA could be screened when discovering myopathies accompanied by unexplained cardiac symptoms. Our findings provide insights into the diagnosis and therapy of this rare and severe disease