P-Lax : toys for adults, to play & relax

Adults don’t play enough. There is so much emphasis on working and being productive in modern day life, but this can have negative effects—for an adult this can lead to high stress and a sense of guilt when one isn’t being productive. My mission is to help adults de-stress and take a break from work by reintroducing play into their day-to-day interactions. Toys for children are often used for educational purposes and to help enhance their creativity and social abilities; toys for adults can instead used to improve mood, and to help release pressure that is built up from everyday work. These toys, which can also be thought of as tools for play, allow adults to use their leisure time to recharge, and can lead to increased productivity as well as a healthier mental state

APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42

Identifying high risk populations is an important component of disease prevention strategies. One approach is examining neuroimaging parameters that differ in Alzheimer’s disease (AD), including functional connections known to be disrupted within the “default mode network” (DMN). We have previously shown these same disruptions in cognitively normal elderly, who have amyloid-beta (Aβ) plaques detected using PIB PET imaging, suggesting neuronal toxicity of plaques. Here we sought to determine if pathological effects of apolipoprotein E ε4 (APOE4) genotype could be seen independent of Aβ plaque toxicity by examining resting state fMRI functional connectivity (fcMRI ) in participants without preclinical fibrillar amyloid deposition (PIB−). Cognitively normal participants enrolled in longitudinal studies (n = 100, mean age = 62) who were PIB− were categorized into those with and without an APOE 4 allele and studied using fcMRI. APOE 4 allele carriers (E4+) differed significantly from E4− in functional connectivity of the precuneus to several regions previously defined as having abnormal connectivity in a group of AD participants. These effects were observed prior to any manifestations of cognitive changes and in the absence of brain fibrillar amyloid-beta (Aβ) plaque deposition, suggesting that early manifestations of a genetic effect can be detected using fcMRI and that these changes may antedate the pathological effects of fibrillar amyloid plaque toxicity

Modified nusinersen intrathecal injection method: inclusion of a septal needle-free closed infusion connector

ObjectiveNusinersen, an extremely expensive biologic drug (around 100,000 US$ per dose) that needs to be administered intrathecally, is approved for the treatment of 5q-spinal muscular atrophy (SMA). Because of the low muscle tone of the back muscles of pediatric SMA patients, especially type 1 SMA patients, the safe, effective, and fast execution of sheath injection is needed. Therefore, a modified intrathecal injection method was developed accordingly. This paper aims to describe the applicability and safety of this modified method.MethodsThe modified intrathecal injection method (MIIM) mainly includes a septal needle-free closed infusion connector between the lumbar puncture needle and the syringe, besides the procedures of routine lumbar puncture. Its applicability and safety were evaluated through clinical observation.ResultsA total of 92 children with SMA have successfully received nusinersen treatment at our hospital using the modified method since 2019 without obvious adverse events related to the modified injection method. Based on the clinical feedback of operators, the advantages of the modified method include successfully injecting the total dose of nusinersen with constant injection rate and a more stable fixation of the puncture needle, as well as making the operator more relaxed. However, compared with the routine method, the procedure of the modified method has additional steps.ConclusionThe modified intrathecal injection method is an effective and safe method to inject nusinersen when weighing the pros and cons, and it may also be used for administering intrathecal injections of other expensive medicines or for patients with other strict requirements for intrathecal injection

Visualizing the Improvement of the Autonomous System: Comparing Three Methods

As one important characteristic of an intelligent product is its ability to evolve, system updates have become vital for its success. In addition, a good perception of system updates may improve users&rsquo; positive attitudes toward the product and encourage continuous usage. However, how to enhance such perception remains largely under-explored. This study investigated how different visualizations of steering performance improvement can influence people&#39;s perception of autonomous vehicles.&nbsp;We measured 120 people&#39;s responses to three different types of visualizing methods. The results showed that the line charts were most effective in increasing the perceived improvement of updates, which could further promote users&rsquo; satisfaction, purchase, and recommendation intentions. We further discussed how our findings could help design future visualization of system updates.</p

Objective Metrics for Assessing Visual Complexity of Vehicle Dashboards: A Machine-Learning Based Study

Dashboard is a central component of an in-vehicle information system (IVIS), and plays a crucial role in providing drivers with key information related but not limited to driving. With the expansion of the IVIS features, modern dashboards additionally integrate various new elements, which often leads to an increase in their visual complexity. Since high visual complexity of the dashboards threatens driving safety and performance, it is essential for researchers and designers to understand what objective features of the dashboards are related to their perceived visual complexity (PVC) so as to establish more cognitively efficient dashboards. In the present study, we refined the objective metrics of assessing visual complexity proposed in previous research and added two new dimensions, colors and animation, to better characterize recent development in the dashboard displays. We then utilized the indicators in the metrics to predict the dashboard PVC. Machine learning was innovatively applied, and the models were found to have stable performance. The study contributes reliable metrics and novel methodology to evaluate the visual complexity of the dashboards for the reference of future studies.</p

Optimal Design of Segmented Planar Imaging System Based on Rotation and CLEAN Algorithm

We propose a parity-baseline segmented planar imaging method with more frequency components by changing different baseline selection to achieve better imaging in the rotational process. A theoretical model of the parity-baseline segmented planar imaging system with rotational operation is built to analyze the imaging effect. The simulation results show that the imaging quality of the parity-baseline segmented planar imaging system has an approximately 20% increase by rotation compared with the conventional system. In addition, the CLEAN algorithm in radio astronomy imaging is also applied to the parity-baseline segmented planar imaging system, and the image quality is further improved by 55%. Such a new imaging method holds great potential toward astronomical observation and detection

Features of Chinese patients with sitosterolemia

Background: Sitosterolemia is a lipid disorder characterized by the accumulation of phytosterols in plasma and organs, caused by mutations in the ABCG5 and/or ABCG8 genes. The disease is frequently misdiagnosed and mistreated as familial hypercholesterolemia (FH). To gain a better understanding of the disease, the current status of diagnosis and treatment of Chinese patients with sitosterolemia was reviewed and summarized. Method: Literature search was performed. The clinical features and molecular characteristics of Chinese patients with sitosterolemia were analysed. Four children with sitosterolemia and the treatment experience were described. Results: Fifty-five patients with sitosterolemia have been reported in China. These patients were aged from 3 months to 67 years at diagnosis, and the median was 8 years of age. Several complications, such as xanthomas in 47 patients (85%), thrombocytopenia in 17 patients (31%), anemia in 14 patients (25%), and cardiovascular damage in 12 patients (22%), were observed. Thirty-nine patients (71%) exhibited mutations in the ABCG5 gene, 15 patients (27%) showed mutations in ABCG8, and variations in both genes occurred in one patient (2%). A patient with two clinically rare diseases, namely, sitosterolemia and glycogen storage disease type VI (GSD VI)), is reported here for the first time. The four reported patients were treated with low cholesterol and phytosterol-limited diet alone or combined with cholestyramine. Even though decreases were observed for total plasma cholesterol (TC) and low-density-lipoprotein cholesterol (LDL-C), and these levels were as low as normal in some patients, the levels of plant sterols remained above the normal range. However, TC, LDL-C and plant sterol levels remained at high levels in patients treated with a control diet control only. Conclusions: The analysis reveals that different from Caucasians carrying mainly variations in ABCG8, most Chinese patients have mutations in the ABCG5 gene, and Arg446Ter, Gln251Ter, anArg389His might be hot-spot mutations in Chinese patients. The current survey provides clinical data to enable the development of a standardized protocol for the diagnosis and treatment of sitosterolemia in China