Design and Experiment of Frequency Offset Estimation and Compensation in High-speed Underwater Acoustic Communication

In underwater acoustic (UWA) communication, Doppler effect is particularly severe due to the slow velocity of sound and the complex variant UWA channel environment. Carrier frequency offset (CFO) can result in extension and compression of the received signal in time domain and has a direct effect on the performance of decoding. In this paper, we propose a new scheme of CFO estimation and compensation for a high speed UWA communication system. There are three steps including coarse CFO estimation, fine CFO estimation and linear interpolation, which are taken to estimate and compensate the CFO. The scheme can eliminate the phenomenon of ambiguous phase and tolerate quick random variation of the CFO in UWA channel. A UWA communication experiment was carried out in December 2012 in the Indian Ocean, off Rottnest Island, Western Australia. With the proposed algorithm in this paper, the UWA system can achieve an average of 1.95% uncoded BER with QPSK modulation at the 1km range and 5.57% with BPSK at the 10km range

Spin Gap and Resonance at the Nesting Wavevector in Superconducting FeSe0.4Te0.6

Neutron scattering is used to probe magnetic excitations in FeSe_{0.4}Te_{0.6} (T_c=14 K). Low energy spin fluctuations are found with a characteristic wave vector $(0.5,0.5,L)$ that corresponds to Fermi surface nesting and differs from Q_m=(\delta,0,0.5) for magnetic ordering in Fe_{1+y}Te. A spin resonance with \hbar\Omega_0=6.5 meV \approx 5.3 k_BT_c and \hbar\Gamma=1.25 meV develops in the superconducting state from a normal state continuum. We show that the resonance is consistent with a bound state associated with s+/- superconductivity and imperfect quasi-2D Fermi surface nesting.Comment: 4 pages, 4 figures, Submitted to Phys. Rev. Let

Transport and structural study of pressure-induced magnetic states in Nd0.55Sr0.45MnO3 and Nd0.5Sr0.5MnO3

Pressure effects on the electron transport and structure of Nd1-xSrxMnO3 (x = 0.45, 0.5) were investigated in the range from ambient to ~6 GPa. In Nd0.55Sr0.45MnO3, the low-temperature ferromagnetic metallic state is suppressed and a low temperature insulating state is induced by pressure. In Nd0.5Sr0.5MnO3, the CE-type antiferromagnetic charge-ordering state is suppressed by pressure. Under pressure, both samples have a similar electron transport behavior although their ambient ground states are much different. It is surmised that pressure induces an A-type antiferromagnetic state at low temperature in both compounds

Effect of Hydrothermal Treatment Temperature on the Properties of Sewage Sludge Derived Solid Fuel

High moisture content along with poor dewaterability are the main challenges for sewage sludge treatment and utilization. In this study, the effect of hydrothermal treatment at various temperature (120-200 ˚C) on the properties of sewage sludge derived solid fuel was investigated in the terms of mechanical dewatering character, drying character, calorific value and heavy metal distribution. Hydrothermal treatment (HT) followed by dewatering process significantly reduced moisture content and improved calorific value of sewage sludge with the optimum condition obtained at 140˚C. No significant alteration of drying characteristic was produced by HT. Heavy metal enrichment in solid particle was found after HT that highlighted the importance of further study regarding heavy metal behavior during combustion. However, it also implied the potential application of HT on sewage sludge for heavy metal removal from wastewater

An Enzymatically Cleavable Tripeptide Linker for Maximizing the Therapeutic Index of Antibody-Drug Conjugates

Valine-citrulline is a protease-cleavable linker commonly used in many drug delivery systems, including antibody-drug conjugates (ADC) for cancer therapy. However, its suboptimal in vivo stability can cause various adverse effects such as neutropenia and hepatotoxicity, leading to dose delays or treatment discontinuation. Here, we report that glutamic acid-glycine-citrulline (EGCit) linkers have the potential to solve this clinical issue without compromising the ability of traceless drug release and ADC therapeutic efficacy. We demonstrate that our EGCit ADC resists neutrophil protease-mediated degradation and spares differentiating human neutrophils. Notably, our anti-HER2 ADC shows almost no sign of blood and liver toxicity in healthy mice at 80 mg kg-1. In contrast, at the same dose level, the FDA-approved anti-HER2 ADCs Kadcyla and Enhertu show increased levels of serum alanine aminotransferase and aspartate aminotransferase and morphologic changes in liver tissues. Our EGCit conjugates also exert greater antitumor efficacy in multiple xenograft tumor models compared with Kadcyla and Enhertu. This linker technology could substantially broaden the therapeutic windows of ADCs and other drug delivery agents, providing clinical options with improved efficacy and safety

Detailed study of the ac susceptibility of Sr2RuO4 in oriented magnetic fields

We have investigated the ac susceptibility of the spin triplet superconductor Sr$_2$RuO$_4$ as a function of magnetic field in various directions at temperatures down to 60 mK. We have focused on the in-plane field configuration (polar angle $\theta \simeq 90^{\circ}$), which is a prerequisite for inducing multiple superconducting phases in Sr$_2$RuO$_4$. We have found that the previous attribution of a pronounced feature in the ac susceptibility to the second superconducting transition itself is not in accord with recent measurements of the thermal conductivity or of the specific heat. We propose that the pronounced feature is a consequence of additional involvement of vortex pinning originating from the second superconducting transition.Comment: Accepted for publication in Phys. Rev.

Space VLBI 2020: Science and Technology Futures Conference Summary

The "Space VLBI 2020: Science and Technology Futures" meeting was the second in The Future of High-Resolution Radio Interferometry in Space series. The first meeting (2018 September 5--6; Noordwijk, the Netherlands) focused on the full range of science applications possible for very long baseline interferometry (VLBI) with space-based antennas. Accordingly, the observing frequencies (wavelengths) considered ranged from below 1~MHz (> 300 m) to above 300~GHz (< 1 mm). For this second meeting, the focus was narrowed to mission concepts and the supporting technologies to enable the highest angular resolution observations at frequencies of 30~GHz and higher (< 1 cm). This narrowing of focus was driven by both scientific and technical considerations. First, results from the RadioAstron mission and the Event Horizon Telescope (EHT) have generated considerable excitement for studying the inner portions of black hole (BH) accretion disks and jets and testing elements of the General Theory of Relativity (GR). Second, the technologies and requirements involved in space-based VLBI differ considerably between 100~MHz and 100~GHz; a related consideration is that there are a number of existing instruments or mission concepts for frequencies of approximately 100~MHz and below, while it has been some time since attention has been devoted to space VLBI at frequencies above 10~GHz. This conference summary attempts to capture elements of presentations and discussions that occurred

Space VLBI 2020: Science and Technology Futures Conference Summary

The "Space VLBI 2020: Science and Technology Futures" meeting was the second in The Future of High-Resolution Radio Interferometry in Space series. The first meeting (2018 September 5--6; Noordwijk, the Netherlands) focused on the full range of science applications possible for very long baseline interferometry (VLBI) with space-based antennas. Accordingly, the observing frequencies (wavelengths) considered ranged from below 1~MHz (> 300 m) to above 300~GHz (< 1 mm). For this second meeting, the focus was narrowed to mission concepts and the supporting technologies to enable the highest angular resolution observations at frequencies of 30~GHz and higher (< 1 cm). This narrowing of focus was driven by both scientific and technical considerations. First, results from the RadioAstron mission and the Event Horizon Telescope (EHT) have generated considerable excitement for studying the inner portions of black hole (BH) accretion disks and jets and testing elements of the General Theory of Relativity (GR). Second, the technologies and requirements involved in space-based VLBI differ considerably between 100~MHz and 100~GHz; a related consideration is that there are a number of existing instruments or mission concepts for frequencies of approximately 100~MHz and below, while it has been some time since attention has been devoted to space VLBI at frequencies above 10~GHz. This conference summary attempts to capture elements of presentations and discussions that occurred.Comment: Nine pages + references and conference schedule appendix; conference Web site http://www.cvent.com/events/space-vlbi-2020/event-summary-c7b30de0068e454591a66e5639f86668.asp

A novel class of microRNA-recognition elements that function only within open reading frames.

MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level. Multiple reports have also indicated the ability of miRNAs to target protein-coding sequences (CDS); however, miRNAs have been generally believed to function through similar mechanisms regardless of the locations of their sites of action. Here, we report a class of miRNA-recognition elements (MREs) that function exclusively in CDS regions. Through functional and mechanistic characterization of these 'unusual' MREs, we demonstrate that CDS-targeted miRNAs require extensive base-pairing at the 3' side rather than the 5' seed; cause gene silencing in an Argonaute-dependent but GW182-independent manner; and repress translation by inducing transient ribosome stalling instead of mRNA destabilization. These findings reveal distinct mechanisms and functional consequences of miRNAs that target CDS versus the 3' UTR and suggest that CDS-targeted miRNAs may use a translational quality-control-related mechanism to regulate translation in mammalian cells